|本期目录/Table of Contents|

[1]武 鑫,李明珍,孙丽荣.2型糖尿病患者血清γ-谷氨酰转移酶与胰岛β细胞功能的关系[J].天津医科大学学报,2014,20(02):147-149.
　WU Xin,LI Ming-zhen,SUN Li-rong.Association of serum gamma-glutamyltransferase with islet β cell function in type 2 diabetic patients[J].Journal of Tianjin Medical University,2014,20(02):147-149.
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2型糖尿病患者血清γ-谷氨酰转移酶与胰岛β细胞功能的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年02期
页码:
147-149
栏目:
临床医学
出版日期:
2014-03-20

文章信息/Info

Title:
Association of serum gamma-glutamyltransferase with islet β cell function in type 2 diabetic patients
文章编号:
1006-8147(2014)02-0147-03
作者:
武 鑫;  李明珍;  孙丽荣
(天津医科大学代谢病医院痛风科,卫生部及天津市激素与发育重点实验室,天津 300070)
Author(s):
WU Xin ;  LI Ming-zhen ;  SUN Li-rong
(Department of Diabetes and Gout,Metabolic Disease Hospital,Tianjin Medicial University,Key Laboratory of Hormones and Development of the Ministry of Health,Tianjin 300070, China)
关键词:
糖尿病; 2型; γ-谷氨酰转移酶; 胰岛β细胞
Keywords:

diabetes mellitus;  type 2;  γ-GGT;  islet β cell

分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
目的:观察血清γ-谷氨酰转移酶（GGT）水平与2型糖尿病患者胰岛β细胞功能之间的关系。方法:选取2型糖尿病患者240例，根据GGT水平四分位数分组，由低到高分为Q1组（GGT≤16.4IU/L）62例、Q2组（16.4IU/L 42.9IU/L）58例。收集所有患者一般临床资料，评估胰岛β细胞功能，分析血清GGT与胰岛β细胞功能的关系。结果:（1）稳态模型评估的胰岛素抵抗指数（HOMA-IR）、胰岛β细胞功能指数（HOMA-β）、胰岛素曲线下面积（AUCINS）随着GGT水平的升高从Q1组到Q4组依次升高（P<0.01）；（2）胰岛素敏感指数（ISI）随着GGT水平的升高从Q1组到Q4组依次下降（P<0.01）；（3）GGT与HOMA-IR（rs =0.372）、HOMA-β（rs =0.369）、AUCINS（rs =0.359）、胰岛素30 min增量（△I30）与血糖30 min增量（△G30）比值（△I30/△G30）（rs =0.201）呈正相关（均P<0.01）；与ISI（rs = -0.326，P<0.01）呈负相关；（4）多元回归分析显示GGT为HOMA-IR的独立危险因子（P<0.05）。结论:2型糖尿病患者血清GGT水平对胰岛素抵抗及胰岛素分泌有一定影响。
Abstract:

Objective: To study the association of serum gamma-glutamyltransferase (GGT) concentration with islet β cell function in type 2 diabetic patients. Methods：A total of 240 cases with type 2 diabetes were divided into four groups according to GGT concentration quartile: group Q1（GGT≤16.4IU/L）,group Q2（16.4IU/L <GGT≤26.4IU/L）,group Q3（26.4IU/L <GGT≤42.9IU/L）,group Q4（GGT >42.9IU/L）, with 62,59,61,58 patients respectively. The general clinical date of all patients were collected and theβcell function were evaluated to analyze the relationship between serum GGT and islet β cell function. Results：(1)Homeostasis model assessment of insulin resistance index(HOMA-IR)，islet βcell function index(HOMA-β)，area under curve of insulin(AUCINS)were elevated significantly and progressively from group Q1 to group Q4（P<0.01）;(2)Insulin resistance index(ISI) decreased significantly and progressively from group Q1 to group Q4（P<0.01）;(3)GGT was positively correlated with HOMA-IR（rs =0.372），HOMA-β（rs =0.369），AUCINS（rs =0.359），the ratio of insulin to glucose from 0 to 30 min (△I30/△G30）（rs =0.201）(P<0.01),but was negatively correlated with ISI（rs = -0.326，P<0.01）;（4）Multiple stepwise regression analysis showed that GGT was an independent risk factor of HOMA-IR (P<0.05). Conclusion：The serum GGT concentration in type 2 diabetic patients can influence insulin resistance and insulin secretion.

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备注/Memo

备注/Memo:
作者简介 武鑫(1988-),女,硕士在读,研究方向:内分泌与代谢病；
通信作者：孙丽荣，E-mail:Sunlirong10@sina.com。

更新日期/Last Update: 2014-03-31