|本期目录/Table of Contents|

[1]马 静,赵立华,谢 云. 血浆纤维蛋白原与糖尿病肾病的相关性研究[J].天津医科大学学报,2015,21(01):60-62.
 MA Jing,ZHAO Li-hua,XIE Yun.Relationship between plasma fibrinogen concentration and diabetic nephropathy[J].Journal of Tianjin Medical University,2015,21(01):60-62.
点击复制

 血浆纤维蛋白原与糖尿病肾病的相关性研究(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21
期数:
2015年01期
页码:
60-62
栏目:
临床医学
出版日期:
2015-01-20

文章信息/Info

Title:
Relationship between plasma fibrinogen concentration and diabetic nephropathy
文章编号:
1006-8147(2015)01-0060-03
作者:
 马 静赵立华谢 云
(天津医科大学代谢病医院神经内科,天津300070)
Author(s):
MA Jing ZHAO Li-hua XIE Yun
(Department of Neurology, Metabolic Disease Hospital ,Tianjin Medical University, Tianjin 300070, China)
关键词:
糖尿病2型血浆纤维蛋白原糖尿病肾病
Keywords:
diabetes mellitus type 2 plasma fibrinogen diabetic nephropathy

分类号:
R587.2
DOI:
-
文献标志码:
A
摘要:
 目的:探讨2型糖尿病(T2DM)患者血浆纤维蛋白原(FIB)与糖尿病肾病(DN)的相关性。 方法: 选取T2DM患者541例,根据24 h尿微量白蛋白(UMA)含量分为3组:D1~D3组。根据FIB水平分为4组:F1~F4组。 结果:D1、D2、D3组间病程、TG、Cr、尿酸(UA)、FIB、高血压患病率差异均有统计学意义(P均< 0.05)。FIB与年龄、TG、TC、LDL-C、Cr、UA、UMA、C反应蛋白(CRP)和高血压呈正相关(P均< 0.05)。与F1组和F2组相比,F3组和F4组发生DN的风险增加(P均< 0.05),校正相关因素后,虽然OR逐渐减少,但发生DN的风险仍然是增加的。对FIB进行ROC曲线分析,曲线下面积(AUC)为0.624±0.026(95%CI为0.574~0.675),P<0.001,最佳临界值为2.90 g/L。 结论: T2DM患者FIB水平与DN具有相关性,FIB高水平可能是T2DM患者发生DN的危险因素。
Abstract:
Objective: To investigate the relationship between plasma fibrinogen (FIB) and diabetic nephropathy (DN) in T2DM patients. Methods: A total of 541 T2DM subjects were enrolled in this study. They were divided into 3 groups according to the micro albumin urine (UMA) content in 24 h, including D1, D2 and D3 group. And according to FIB, the patients were divided into F1, F2,F3 and F4 groups. Results: Statistically significant differences in duration, TG, Cr, UA, FIB and the prevalence rate of hypertension among the D1~D3 groups were found (P<0.05). The FIB level was significantly positively correlated with age, TG, TC, LDL-C, Cr, UA, UMA, CRP and the prevalence rate of hypertension (P< 0.05). Compared with F1 group and F2 group, risk of DN significantly increased in F3 group and F4 group(P< 0.05). After adjusting the related risk factors such as duration, TG, Cr, UA and the prevalence rate of hypertension, the ORs were attenuated but the risk of DN remained increasing. FIB was analyzed by ROC curve with the area under the curve (AUC) being 0.624 ± 0.026 (95%CI 0.574~0.675) (P<0.001) and the optimal critical value was 2.90 g/L. Conclusion: The FIB level in T2DM subjects is significantly associated with DN. The high FIB level may be one of the risk factors for DN in T2DM patients.

参考文献/References:

[1] 陈仁涉,高芳坤,魏洁. 微量白蛋白尿的发生机理、预后及治疗[J]. 国外医学.临床生物化学与检验学分册,1997(04):156

[2] 叶国强. 糖化血红蛋白及血脂检测在Ⅱ型糖尿病肾病病程中的变化关系[J]. 实验与检验医学,2009(02):127

[3] Coban E, Sari R, Ozdogan M, et al. Levels of plasma fibrinogen and d-dimer in patients with impaired fasting glucose[J]. Exp Clin Endocrinol Diabetes,2005,113(1):35

[4] 李桂英. 糖尿病患者血浆纤维蛋白原及D-二聚体水平变化及意义[J]. 临床医学,2010,23(3):652

[5] 阮森林,夏晴辉,丁成国. 2型糖尿病肾病患者超敏CRP、纤维蛋白原及D-二聚体水平变化的临床意义[J]. 中国卫生检验杂志,2012,22(6):1359

[6] 王莉. 2型糖尿病患者血浆D二聚体及血浆纤维蛋白原监测的临床意义[J]. 检验医学与临床,2011,8(8):974

[7] 姚颖,张蔷. 2型糖尿病患者血液流变学分析[J]. 中国慢性病预防与控制,2011(04):420

[8] Sobel B E, Hardison R M, Genuth S, et al. Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial[J]. Circulation,2011,124(6):695

[9] 王照峰,张虎,马红雨,等. 2型糖尿病微血管病变患者D-二聚体、FIB及Lp(a)检测的临床意义[J]. 中国误诊学杂志,2012,12(5):1108

[10] 王照峰,张虎,赵瑞敏,等. D-二聚体、FIB检测2型糖尿病合并微血管病变时的临床意义[J]. 空军医学杂志,2012,28(3):132

[11] 李春仙,史训忠. 2型糖尿病肾病患者血D-二聚体、纤维蛋白原、C反应蛋白水平的临床意义[J]. 检验医学,2010,25(2):107

[12] 周立红,刘敏涓,石惠敏,等. 慢性肾功能衰竭血液透析对纤维蛋白原的影响[J]. 中原医刊,2000(02):28

[13] 苏景岩. 2型糖尿病患者血浆D-二聚体、凝血四项指标变化的分析及临床意义[J]. 心血管病防治知识,2011(3):13

相似文献/References:

[1]李 冰,冯 凭.罗格列酮干预糖尿病大鼠脂肪组织CMKLR1及Chemerin基因表达[J].天津医科大学学报,2015,21(06):484.
 LI Bing,FENG Ping.Effect of rosiglitazone on the expression of CMKLR1 and Chemerin mRNA in the adipose tissue of diabetic rat[J].Journal of Tianjin Medical University,2015,21(01):484.
[2]赵一贺,张 畅,牛文彦.电脉冲刺激的骨骼肌细胞条件培养基逆转内皮细胞胰岛素抵抗和功能障碍[J].天津医科大学学报,2017,23(01):1.
 ZHAO Yi-he,ZHANG Chang,NIU Wen-yan.Conditional medium from electric pulse-stimulated C2C12 skeletal muscle cells reverses insulin resistance and endothelial dysfunction in endothelial cells[J].Journal of Tianjin Medical University,2017,23(01):1.
[3]刘 豫,薄志强,张志宏.糖尿病及二甲双胍对上尿路肿瘤术后复发的影响[J].天津医科大学学报,2017,23(01):53.
 LIU Yu,BO Zhi-qiang,ZHANG Zhi-hong.Effect of diabetes mellitus and metformin on intravesical recurrence after radical operation in patients with upper urinary tract urothelial carcinoma[J].Journal of Tianjin Medical University,2017,23(01):53.
[4]周冷潇,韩 涛.慢性乙型病毒性肝炎肝硬化发生肝细胞癌的危险因素分析[J].天津医科大学学报,2017,23(03):214.
 ZHOU Leng-xiao,HAN Tao.Risk factors of hepatocellular carcinoma in patients with hepatitis B virus-related liver cirrhosis[J].Journal of Tianjin Medical University,2017,23(01):214.
[5]郝欣阳,刘洪梅,袁 梦,等.冠心病合并糖尿病患者血清CARP水平与冠脉病变关系的研究[J].天津医科大学学报,2017,23(04):337.
 HAO Xin-yang,LIU Hong-mei,YUAN Meng,et al.Study on the relationship between? serum CARP level??and the severity of coronary artery lesion in patients with coronary artery disease combined with diabetes[J].Journal of Tianjin Medical University,2017,23(01):337.
[6]王开毫,田伟军.糖尿病对胰十二指肠切除术后并发症的影响[J].天津医科大学学报,2017,23(04):354.
 WANG Kai-hao,TIAN Wei-jun.Impact of diabetes mellitus on postoperative complications after pancreaticoduodenectomy[J].Journal of Tianjin Medical University,2017,23(01):354.
[7]李瀚琪,牛文彦.iNOS调节Rab8参与肥胖诱导的胰岛素抵抗[J].天津医科大学学报,2019,25(03):201.
 LI Han-qi,NIU Wen-yan.iNOS participates in obesity-induced insulin resistance by regulating Rab8[J].Journal of Tianjin Medical University,2019,25(01):201.
[8]刘 欣.深部脓肿合并糖尿病患者外科治疗效果分析[J].天津医科大学学报,2019,25(05):504.
 LIU Xin.Effect of surgical treatment on patients with deep abscess complicated with diabetes mellitus[J].Journal of Tianjin Medical University,2019,25(01):504.
[9]王树峰,杨 丽,刘 寅.脂蛋白相关磷脂酶A2与冠心病和2型糖尿病的关系[J].天津医科大学学报,2013,19(06):456.
 WANG Shu-feng,YANG Li,LIU Yin.Relationship between lipoprotein-associated phospholipase A2 and coronary heart disease as well as type 2 diabetes mellitus[J].Journal of Tianjin Medical University,2013,19(01):456.
[10]苏东峰,聂秀玲,孙丽荣.2型糖尿病合并高尿酸血症临床特征及相关危险因素分析[J].天津医科大学学报,2013,19(06):481.
[11]武 鑫,李明珍,孙丽荣.2型糖尿病患者血清γ-谷氨酰转移酶与胰岛β细胞功能的关系[J].天津医科大学学报,2014,20(02):147.
 WU Xin,LI Ming-zhen,SUN Li-rong.Association of serum gamma-glutamyltransferase with islet β cell function in type 2 diabetic patients[J].Journal of Tianjin Medical University,2014,20(01):147.
[12]刘 芳,李明珍,孙丽荣.住院2型糖尿病患者睡眠质量与血糖及并发症的关系[J].天津医科大学学报,2014,20(03):213.
 LIU Fang,LI Ming-zhen,SUN Li-rong.Relationship between sleep quality and glucose level as well as diabetic complications in hospital patients with type 2 diabetes mellitus[J].Journal of Tianjin Medical University,2014,20(01):213.
[13]李凤英,朱铁虹.中年男性2型糖尿病患者促甲状腺激素与尿钙/肌酐比值的相关性研究[J].天津医科大学学报,2014,20(05):389.
 LI Feng-ying,ZHU Tie-hong.Relationship between thyroid stimulating hormone and urinary calcium/creatinine excretion in middle-aged man with type 2 diabetes[J].Journal of Tianjin Medical University,2014,20(01):389.
[14]谭艳萍,吴校伟,刘 寅,等. 冠心病合并糖尿病患者药物涂层支架术后观察[J].天津医科大学学报,2014,20(05):414.
[15]陈河清,郭秀梅,金力里.2型糖尿病患者牙周病与糖尿病肾病的相关性分析[J].天津医科大学学报,2014,20(06):469.
 CHEN He-qing,GUO Xiu-mei,JIN Li-li. Correlation between diabetic nephropathy and periodontal disease[J].Journal of Tianjin Medical University,2014,20(01):469.
[16]马 静,赵立华,谢 云.血浆纤维蛋白原与糖尿病肾病的相关性研究[J].天津医科大学学报,2015,21(03):60.
 Ma Jing,ZHAO Li-hua,XIE Yun.Relationship between plasma fibrinogen concentration and diabetic nephropathy [J].Journal of Tianjin Medical University,2015,21(01):60.
[17]姚 旻,赵爱源,张晓会,等.人体肥胖指数与2型糖尿病肾病的相关性研究[J].天津医科大学学报,2016,22(03):230.
 YAO Min,ZHAO Ai-yuan,ZHANG Xiao-hui,et al.Study on the relationship between body adiposity index and diabetic nephropathy in patients with type 2 diabetes mellitus[J].Journal of Tianjin Medical University,2016,22(01):230.

备注/Memo

备注/Memo:
作者简介 马静(1989-),女,硕士在读,研究方向:内分泌与代谢病;
通信作者:谢云, E-mail : tjxieyun0108@sina.com 。
更新日期/Last Update: 2015-06-11