|本期目录/Table of Contents|

[1]周冷潇,韩 涛.慢性乙型病毒性肝炎肝硬化发生肝细胞癌的危险因素分析[J].天津医科大学学报,2017,23(03):214-216.
 ZHOU Leng-xiao,HAN Tao.Risk factors of hepatocellular carcinoma in patients with hepatitis B virus-related liver cirrhosis[J].Journal of Tianjin Medical University,2017,23(03):214-216.
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慢性乙型病毒性肝炎肝硬化发生肝细胞癌的危险因素分析(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23
期数:
2017年03期
页码:
214-216
栏目:
临床医学
出版日期:
2017-05-18

文章信息/Info

Title:
Risk factors of hepatocellular carcinoma in patients with hepatitis B virus-related liver cirrhosis
文章编号:
1006-8147(2017)03-0214-03
作者:
周冷潇12韩 涛12
(1.天津医科大学第三中心临床学院肝内科, 天津 300170; 2.天津市第三中心医院肝内科,天津 300170)
Author(s):
ZHOU Leng-xiao12 HAN Tao12
(1.Department of Hepatology, The Third Central Clinical College, Tianjin Medical University, Tianjin 300170, China;2.Department of Hepatology,Tianjin Third Central Hospital, Tianjin 300170, China)
关键词:
慢性乙型病毒性肝炎肝硬化肝细胞癌糖尿病
Keywords:
hepatitis B liver cirrhosis hepatocellular carcinoma diabetes mellitus
分类号:
R575.1
DOI:
-
文献标志码:
A
摘要:
?目的: 探讨慢性乙型病毒性肝炎肝硬化发生肝细胞癌(HCC)的危险因素。方法: 研究对象为317例慢性乙肝患者,包括183例慢乙肝肝硬化患者(肝硬化组)和134例慢乙肝相关HCC患者(HCC组),对其性别、年龄、吸烟及饮酒习惯、伴发疾病、实验室检查指标等资料进行比较,探讨慢乙肝肝硬化发生HCC的危险因素。结果: HCC组患者男性所占比例、年龄、有长期大量饮酒习惯、血HBV DNA阳性、合并糖尿病(DM)及高血压所占比例均高于肝硬化组,两组比较P均<0.05。Logistic回归分析显示,男性、年龄较大、血HBV DNA阳性、DM是慢乙肝肝硬化患者发生HCC的独立危险因素(OR分别为0.326、1.055、2.988、2.031,P均<0.05)。结论: 男性、年龄升高、血HBV DNA阳性、DM是慢乙肝肝硬化患者发生HCC的独立危险因素。
Abstract:
?Objective: To investigate the risk factors of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related liver cirrhosis. Methods: A total of 317 patients with chronic hepatitis B were selected and divided into two groups: cirrhosis group with 183 patients and HCC group with 134 group. A case control study was conducted and the two groups were compared in terms of gender, age, smoking and drinking habits, accompanied disease and laboratory test results to explore the risk factors of HCC in patients with HBV-related liver cirrhosis. Results: The mean age, the proportions of men, drinking habits, HBV DNA positive and diabetes mellitus (DM) in HCC group were significantly higher than cirrhosis group, P<0.05. Logistic regression showed that sex, age, HBV DNA positive and DM were independent risk factors for HCC in patients with HBV-related liver cirrhosis (OR=0.326, OR=1.055, OR=2.988, OR=2.031, respectively, all P<0.05). Conclusions: Sex, older age, HBV DNA positive and DM are independent risk factors for HCC in patients with HBV-related liver cirrhosis.

参考文献/References:

[1]陈磊.我国肝癌研究的现状与背景[J].生命科学,2015,27(3):237
[2]Yin J, Zhang H W, He Y C, et al. Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study[J]. Cancer Epidemiol Biomarkers Prev, 2010, 19(3): 777
[3]Yu S J, Kim Y J. Hepatitis B viral load affects prognosis of hepatocellular carcinoma[J]. World J Gastroenterol, 2014, 20(34): 12039
[4]齐小秋,王宇,卫生部疾病预防控制局,等.全国人群乙型病毒性肝炎血清流行病学调查报告[M].北京:人民卫生出版社,2011:55
[5]Wang S, Fan J G, Zhang Z, et al. The global burden of liver disease: the major impact of China[J]. Hepatology, 2014, 60(6): 2099
[6]沈锋,张小峰.原发性肝癌肝切除术质量控制若干问题[J].中国实用外科杂志,2016,36(1):11
[7]Li Y, Zhang Z, Shi J F, et al. Risk factors for naturally-occurring early-onset hepatocellular carcinoma in patients with HBV-associated liver cirrhosis in China[J]. Int J Clin Exp Med, 2015, 8(1): 1205
[8]El Mahdy Korah T, Abd Elfatah Badr E, Mohamed Emara M, et al. Relation between sex hormones and hepatocellular carcinoma[J]. Andrologia, 2016, 48(9): 948
[9]Yuen M F, Tanaka Y, Fong D Y, et al. Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B[J]. J Hepatol, 2008, 48(2): S252
[10]Sangiovanni A, Del Ninno E, Fasani P, et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance[J].Gastroenterology, 2004,126(4): 1005
[11]Lee J, Sinn D H, Kim J H, et al. Hepatocellular carcinoma risk of compensated cirrhosis patients with elevated HBV DNA levels according to serum aminotransferase levels[J]. J Korean Med Sci, 2015, 30(11): 1618
[12]Yu M C, Yuan J M. Environmental factors and risk for hepatocellular carcinoma[J]. Gastroenterology, 2004, 127(5 Suppl 1): S72
[13]Mast E E, Weinbaum C M, Fiore A E, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults[J]. MMWR Recomm Rep, 2006, 55(RR/16): 1
[14]Xu Y, Wang L M, He J, et al. Prevalence and control of diabetes in Chinese adults[J]. JAMA, 2013, 310(9): 948
[15]Elkrief L, Rautou P E, Sarin S, et al. Diabetes mellitus in patients with cirrhosis: clinical implications and management[J]. Liver International, 2016, 36(7): 936
[16]Li Q, Li W W, Yang X, et al. Type 2 diabetes and hepatocellular carcinoma: A case-control study in patients with chronic hepatitis B[J]. Inter J Cancer, 2012, 131(5): 1197
[17]Wang C S, Yao W J, Chang T T, et al. The impact of type 2 diabetes on the development of hepatocellular carcinoma in different viral hepatitis statuses[J]. Cancer Epidemiol Biomarkers Prev, 2009, 18(7): 2054
[18]Zheng Z, Zhang C, Yan J, et al. Diabetes mellitus is associated with hepatocellular carcinoma:a retrospective case-control study in hepatitis endemic area[J]. PLoS One, 2013, 8(12): e84776
[19]Hassan M M, Curley S A, Li D H, et al. Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma[J]. Cancer, 2010, 116(8): 1938

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备注/Memo

备注/Memo:

基金项目 国家科技重大专项基金资助(2012ZX10002004-011);天津市科技计划项目(13RCGFSY19200)

作者简介 周冷潇(1991-),女,硕士在读, 研究方向:主要从事肝脏相关疾病研究;

通信作者 :韩涛 ,E-mail:hantaomd@126.com。



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更新日期/Last Update: 2017-05-18