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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年03期

页码:

214-216

栏目:

临床医学

出版日期:

2017-05-18

文章信息/Info

Title:

Risk factors of hepatocellular carcinoma in patients with hepatitis B virus-related liver cirrhosis

文章编号:

1006-8147(2017)03-0214-03

作者:

周冷潇¹; 2; 韩 涛¹; 2

(1.天津医科大学第三中心临床学院肝内科, 天津 300170; 2.天津市第三中心医院肝内科,天津 300170)

Author(s):

ZHOU Leng-xiao¹; 2;  HAN Tao¹; 2

(1.Department of Hepatology, The Third Central Clinical College, Tianjin Medical University, Tianjin 300170, China；2.Department of Hepatology，Tianjin Third Central Hospital, Tianjin 300170, China)

关键词:

慢性乙型病毒性肝炎; 肝硬化; 肝细胞癌; 糖尿病

Keywords:

hepatitis B ;  liver cirrhosis;  hepatocellular carcinoma;  diabetes mellitus

分类号:

R575.1

DOI:

-

文献标志码:

A

摘要:

?目的: 探讨慢性乙型病毒性肝炎肝硬化发生肝细胞癌（HCC）的危险因素。方法: 研究对象为317例慢性乙肝患者，包括183例慢乙肝肝硬化患者（肝硬化组）和134例慢乙肝相关HCC患者（HCC组），对其性别、年龄、吸烟及饮酒习惯、伴发疾病、实验室检查指标等资料进行比较，探讨慢乙肝肝硬化发生HCC的危险因素。结果: HCC组患者男性所占比例、年龄、有长期大量饮酒习惯、血HBV DNA阳性、合并糖尿病（DM）及高血压所占比例均高于肝硬化组，两组比较P均<0.05。Logistic回归分析显示，男性、年龄较大、血HBV DNA阳性、DM是慢乙肝肝硬化患者发生HCC的独立危险因素（OR分别为0.326、1.055、2.988、2.031，P均<0.05）。结论: 男性、年龄升高、血HBV DNA阳性、DM是慢乙肝肝硬化患者发生HCC的独立危险因素。

Abstract:

?Objective: To investigate the risk factors of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related liver cirrhosis. Methods: A total of 317 patients with chronic hepatitis B were selected and divided into two groups: cirrhosis group with 183 patients and HCC group with 134 group. A case control study was conducted and the two groups were compared in terms of gender, age, smoking and drinking habits, accompanied disease and laboratory test results to explore the risk factors of HCC in patients with HBV-related liver cirrhosis. Results: The mean age, the proportions of men, drinking habits, HBV DNA positive and diabetes mellitus (DM) in HCC group were significantly higher than cirrhosis group, P<0.05. Logistic regression showed that sex, age, HBV DNA positive and DM were independent risk factors for HCC in patients with HBV-related liver cirrhosis (OR=0.326, OR=1.055, OR=2.988, OR=2.031, respectively, all P<0.05). Conclusions: Sex, older age, HBV DNA positive and DM are independent risk factors for HCC in patients with HBV-related liver cirrhosis.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目 国家科技重大专项基金资助（2012ZX10002004-011）；天津市科技计划项目（13RCGFSY19200）

作者简介 周冷潇（1991-），女，硕士在读， 研究方向：主要从事肝脏相关疾病研究；

通信作者 ：韩涛 ，E-mail:hantaomd@126.com。

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更新日期/Last Update: 2017-05-18