[1] BUTLER A E,JANSON J,BONNER-WEIR S,et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes[J]. Diabetes,2003,52(1):102-110.
[2] ACCILI D. Insulin action research and the future of diabetes treatment:the 2017 Banting medal for scientific achievement lecture[J]. Diabetes,2018,67(9):1701-1709.
[3] ZIMMER Y,MILO-LANDESMAN D,SVETLANOV A,et al. Genes induced by growth arrest in a pancreatic beta cell line:identification by analysis of cDNA arrays[J]. FEBS Lett,1999,457(1):65-70.
[4] GERSHENGORN M C,HARDIKAR A A,WEI C,et al. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells[J]. Science,2004,306(5705):2261-2264.
[5] BENSELLAM M,JONAS J C,LAYBUTT D R. Mechanisms of beta-cell dedifferentiation in diabetes:recent findings and future research directions[J]. J Endocrinol,2018,236(2):R109-R143.
[6] MEZZA T,CINTI F,CEFALO C M A,et al. beta-Cell fate in human insulin resistance and type 2 diabetes:a perspective on islet plasticity[J]. Diabetes,2019,68(6):1121-1129.
[7] RORSMAN P,ASHCROFT F M. Pancreatic beta-cell electrical activity and insulin secretion:of mice and men[J]. Physiol Rev,2018,98(1):117-214.
[8] EFRAT S. Beta-cell dedifferentiation in type 2 diabetes:concise review[J]. Stem Cells,2019,37(10):1267-1272.
[9] CHAE H,AUGUSTIN R,GATINEAU E,et al. SGLT2 is not expressed in pancreatic alpha- and beta-cells,and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans[J]. Mol Metab,2020,42:101071.
[10] GAO T,MCKENNA B,LI C,et al. Pdx1 maintains beta cell identity and function by repressing an alpha cell program[J]. Cell Metab,2014,19(2):259-271.
[11] RATTANAAMNUAYCHAI P,ROSHORM Y M,WILASRUSMEE C,et al. Direct suppression of human islet dedifferentiation,progenitor genes,but not epithelial to mesenchymal transition by liraglutide[J]. Heliyon,2020,6(9):e04951.
[12] SEIRON P,WIBERG A,KURIC E,et al. Characterisation of the endocrine pancreas in type 1 diabetes:islet size is maintained but islet number is markedly reduced[J]. J Pathol Clin Res,2019,5(4):248-255.
[13] CASTEELS T,ZHANG Y,FROGNE T,et al. An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation[J]. Mol Metab,2021,54:101329.
[14] ZHANG Z,HU Y,XU N,et al. A new way for beta cell neogenesis:transdifferentiation from alpha cells induced by glucagon-like peptide 1[J]. J Diabetes Res,2019,2019:2583047.
[15] YOSHIKAWA H,TAJIRI Y,SAKO Y,et al. Effects of free fatty acids on beta-cell functions:a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox[J]. Metabolism,2001,50(5):613-618.
[16] HUANG C,YUAN L,CAO S. Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets[J]. Int J Mol Med,2015,36(1):173-185.
[17] SPIJKER H S,SONG H,ELLENBROEK J H,et al. Loss of beta-cell identity occurs in type 2 diabetes and is associated with islet amyloid deposits[J]. Diabetes,2015,64(8):2928-2938.
[18] ACREMAN S,ZHANG Q. Regulation of alpha-cell glucagon secretion:the role of second messengers[J]. Chronic Dis Transl Med,2022,8(1):7-18.
[19] MEMON B,KARAM M,AL-KHAWAGA S,et al. Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1[J]. Stem Cell Res Ther,2018,9(1):15.
[20] HAMAD A,HYER J M,THAYAPARAN V,et al. Pancreatogenic diabetes after partial pancreatectomy:a common and understudied cause of morbidity[J]. J Am Coll Surg,2022,235(6):838-845.
[21] VILLACA C B P,DE PAULA C C,DE OLIVEIRA C C,et al. Beneficial effects of physical exercise for beta-cell maintenance in a type 1 diabetes mellitus animal model[J]. Exp Physiol,2021,106(7):1482-1497.
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