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[1]武 鑫,李明珍,孙丽荣.2型糖尿病患者血清γ-谷氨酰转移酶与胰岛β细胞功能的关系[J].天津医科大学学报,2014,20(02):147-149.
 WU Xin,LI Ming-zhen,SUN Li-rong.Association of serum gamma-glutamyltransferase with islet β cell function in type 2 diabetic patients[J].Journal of Tianjin Medical University,2014,20(02):147-149.
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2型糖尿病患者血清γ-谷氨酰转移酶与胰岛β细胞功能的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20
期数:
2014年02期
页码:
147-149
栏目:
临床医学
出版日期:
2014-03-20

文章信息/Info

Title:
Association of serum gamma-glutamyltransferase with islet β cell function in type 2 diabetic patients
文章编号:
1006-8147(2014)02-0147-03
作者:
武 鑫 李明珍 孙丽荣
(天津医科大学代谢病医院痛风科,卫生部及天津市激素与发育重点实验室,天津 300070)
Author(s):
WU Xin LI Ming-zhen SUN Li-rong
(Department of Diabetes and Gout,Metabolic Disease Hospital,Tianjin Medicial University,Key Laboratory of Hormones and Development of the Ministry of Health,Tianjin 300070, China)
关键词:
糖尿病2型γ-谷氨酰转移酶胰岛β细胞
Keywords:

diabetes mellitus type 2 γ-GGT islet β cell

分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
目的:观察血清γ-谷氨酰转移酶(GGT)水平与2型糖尿病患者胰岛β细胞功能之间的关系。方法:选取2型糖尿病患者240例,根据GGT水平四分位数分组,由低到高分为Q1组(GGT≤16.4IU/L)62例、Q2组(16.4IU/L 42.9IU/L)58例。收集所有患者一般临床资料,评估胰岛β细胞功能,分析血清GGT与胰岛β细胞功能的关系。结果:(1)稳态模型评估的胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)、胰岛素曲线下面积(AUCINS)随着GGT水平的升高从Q1组到Q4组依次升高(P<0.01);(2)胰岛素敏感指数(ISI)随着GGT水平的升高从Q1组到Q4组依次下降(P<0.01);(3)GGT与HOMA-IR(rs =0.372)、HOMA-β(rs =0.369)、AUCINS(rs =0.359)、胰岛素30 min增量(△I30)与血糖30 min增量(△G30)比值(△I30/△G30)(rs =0.201)呈正相关(均P<0.01);与ISI(rs = -0.326,P<0.01)呈负相关;(4)多元回归分析显示GGT为HOMA-IR的独立危险因子(P<0.05)。结论:2型糖尿病患者血清GGT水平对胰岛素抵抗及胰岛素分泌有一定影响。
Abstract:

Objective: To study the association of serum gamma-glutamyltransferase (GGT) concentration with islet β cell function in type 2 diabetic patients. MethodsA total of 240 cases with type 2 diabetes were divided into four groups according to GGT concentration quartile: group Q1(GGT≤16.4IU/L),group Q2(16.4IU/L <GGT≤26.4IU/L),group Q3(26.4IU/L <GGT≤42.9IU/L),group Q4(GGT >42.9IU/L), with 62,59,61,58 patients respectively. The general clinical date of all patients were collected and theβcell function were evaluated to analyze the relationship between serum GGT and islet β cell function. Results(1)Homeostasis model assessment of insulin resistance index(HOMA-IR),islet βcell function index(HOMA-β),area under curve of insulin(AUCINS)were elevated significantly and progressively from group Q1 to group Q4(P<0.01);(2)Insulin resistance index(ISI) decreased significantly and progressively from group Q1 to group Q4(P<0.01);(3)GGT was positively correlated with HOMA-IR(rs =0.372),HOMA-β(rs =0.369),AUCINSrs =0.359),the ratio of insulin to glucose from 0 to 30 min (△I30/△G30)(rs =0.201)(P<0.01),but was negatively correlated with ISI(rs = -0.326,P<0.01);(4)Multiple stepwise regression analysis showed that GGT was an independent risk factor of HOMA-IR (P<0.05). ConclusionThe serum GGT concentration in type 2 diabetic patients can influence insulin resistance and insulin secretion.

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备注/Memo

备注/Memo:
作者简介 武鑫(1988-),女,硕士在读,研究方向:内分泌与代谢病;
通信作者:孙丽荣,E-mail:Sunlirong10@sina.com。

更新日期/Last Update: 2014-03-31