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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

19卷

期数:

2013年06期

页码:

456-458

栏目:

临床医学

出版日期:

2013-11-20

文章信息/Info

Title:

Relationship between lipoprotein-associated phospholipase A2 and coronary heart disease as well as type 2 diabetes mellitus

作者:

王树峰¹; 杨 丽²; 刘 寅²

1.天津医科大学胸科临床学院心内二科，天津 300051；2.天津市胸科医院心内二科，天津 300051

Author(s):

WANG Shu-feng¹;  YANG Li²;  LIU Yin²

1. Department of Cardiology, Thoracic Clinical College,Tianjin Medical University,Tianjin 300051，China；2.Department of Cardiology,Tianjin Chest Hospital,Tianjin 300051，China

关键词:

脂蛋白相关磷脂酶A2; 糖尿病; 2型; 冠状动脉疾病; Gensini积分

Keywords:

lipoprotein-associated phospholipase A2;  didabetes mellitus;  type 2;  coronary artery disease;  Gensini score

分类号:

R587.2

DOI:

-

文献标志码:

A

摘要:

目的：探讨脂蛋白相关磷脂酶A2（Lp-PLA2）与冠心病（CHD）和2型糖尿病（T2DM）的关系。方法：入选患者200例，分为4组，CHD组80例，T2DM组20例，CHD+T2DM组60例，对照组（非CHD非T2DM组）４０例。检测Lp-PLA2及C反应蛋白（CRP）。采用析因设计方差分析研究Lp-PLA2及CRP与CHD和 T2DM的相关性。同时分析CHD合并T2DM患者Lp-PLA2水平与冠脉病变程度的相关性。结果：CHD组、T2DM组、CHD+T2DM组Lp-PLA2及CRP均高于对照组（均P<0.05），且经析因设计方差分析显示CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用（F=7.62，P<0.05；F=9.68，P<0.05）。CHD+T2DM组冠脉Gensini积分大于CHD组（44.15±36.28 vs 60.51±42.58，P=0.020）。CHD组Lp-PLA2水平与Gensini积分呈正相关（r=0.181，P=0.016），CHD+T2DM组Lp-PLA2水平与Gensini积分也呈正相关（r=0.224，P=0.011），且后者相关性更好。结论：CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用；与单纯CHD患者相比，CHD合并T2DM患者Lp-PLA2水平更高，冠脉病变更重。

Abstract:

Objective: To explore the relationship between lipoprotein-associated phospholipase A2(Lp-PLA2) and coronary heart disease(CHD) as well as type 2 diabetes mellitus (T2DM). Methods: Two hundred patients were enrolled in the study, and were subdivided into four groups. Factorial analysis of variance was used to study the relationships between Lp-PLA2 and CHD as well as T2DM, and the relationships between C-reaction protein(CRP) and CHD as well as T2DM.And the correlation between the level of Lp-PLA2 and the severity of coronary atherosclerosis of patients with CHD and T2DM was calculated. Results: The levels of CRP of CHD group, T2DM group, and CHD+T2DM group were all higher than those of the control group (all P<0.05). So was the level of Lp-PLA2 (all P<0.05). Factorial analysis of variance showed CHD and T2DM could interact with CRP and Lp-PLA2 (F=7.62, P<0.05; F=9.68, P<0.05). The Gensini score of CHD+T2DM group was higher than that of CHD group (44.15±36.28 vs 60.51±42.58, P=0.020). The level of Lp-PLA2 was positively correlated with the Gensini score in the CHD group (r=0.181，P=0.016). And so was the levels of Lp-PLA2 in the CHD+T2DM group (r=0.224，P=0.011). Conclusion: CHD and T2DM can interact with CRP and Lp-PLA2. Compared with the patients with coronary heart disease alone, the level of Lp-PLA2 is higher and the coronary atherosclerosis is more severe for the patients with coronary heart disease and type 2 diabetes.

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备注/Memo

备注/Memo:

基金项目 天津市卫生局科技基金资助项目（2011kz63） 作者简介 王树峰（1987-），男，医师，硕士在读，研究方向：冠心病基础与临床；通信作者：杨丽，E-mail：yanglee_19771225@sina.com。

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更新日期/Last Update: 2013-12-20