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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

20卷

期数:

2014年04期

页码:

169

栏目:

出版日期:

2014-07-08

文章信息/Info

Title:

Expression of CXCR4 and CathepsinD in malignant fibrous histiocytoma and their biological significance

作者:

 班新超1; 2; 3 ; 孙保存1; 3; 谷彦军1; 3 ; 魏秀平1; 3;  娄丹1; 3; 李庆选2 ; 郑燕君1

（1.天津医科大学病理学教研室,天津 300070；2.天津市天津医院病理科，天津300060；3.天津医科大学附属肿瘤医院病理科，天津 300060 ）

Author(s):

BAN Xin-chao1; 2; 3;  SUN Bao-cun1; 3;  GU Yan-jun1; 34;  WEI Xiu-ping1; 3;  LOU Dan1; 3;  LI Qing-xuan2;  ZHENG Yan-jun1

(1.Department of Pathology, Tianjin Medical University, Tianjin 30070, China; 2. Department of Pathology, Tianjin Hospital, Tianjin 300060, China; 3 .Department of Pathology, Cancer Institute and Hospital , Tianjin Medical University, Tianjin, 300060,China)

关键词:

恶性纤维组织细胞瘤; 转移; CXCR4; CathepsinD

Keywords:

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分类号:

-

DOI:

-

文献标志码:

A

摘要:

目的：探讨CXCR4和组织蛋白酶D（CathepsinD）的表达与恶性纤维组织细胞瘤（MFH）转移及预后的关系。方法：选取存档的55例MFH组织标本，根据临床资料分为有转移组和无转移组，利用免疫组织化学染色检测两组原发灶中CXCR4和CathepsinD蛋白的表达情况，比较其过表达患者与低表达患者的中位生存期；利用Real-time PCR检测20例MFH有转移组和无转移组原发灶中CXCR4和CathepsinD的mRNA表达水平。结果：CXCR4和CathepsinD表达水平在转移组均显著高于无转移组(P<0.05)；CXCR4过表达者的中位生存期均显著低于其低表达者（P<0.05）；CathepsinD过表达者的中位生存期低于其低表达者，但差异无显著性（P>0.05）。结论：过表达CXCR4和CathepsinD与MFH的远处转移有关，CXCR4可作为MFH预后不良的参考指标。

Abstract:

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参考文献/References:

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更新日期/Last Update: 2014-06-06