|本期目录/Table of Contents|

[1]刘晓丽,黄 勇,杨丽敏,等.二氢嘧啶脱氢酶基因的T85C和A1627G联合突变对乳腺癌患者预后的影响[J].天津医科大学学报,2016,22(05):412-416.
　LIU Xiao-li,HUANG Yong,YANG Li-min,et al.Effect of combined mutations of T85C and A1627G in dihydropyrimidine dehydrogenase gene on prognosis of patients with breast cancer[J].Journal of Tianjin Medical University,2016,22(05):412-416.
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二氢嘧啶脱氢酶基因的T85C和A1627G联合突变对乳腺癌患者预后的影响(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年05期
页码:
412-416
栏目:
临床医学
出版日期:
2016-09-20

文章信息/Info

Title:
Effect of combined mutations of T85C and A1627G in dihydropyrimidine dehydrogenase gene on prognosis of patients with breast cancer
文章编号:
1006-8147（2016）05-0412-05
作者:
?刘晓丽; 黄 勇; 杨丽敏; 余 峰; 谷 峰; 马勇杰
?(天津医科大学肿瘤医院研究所肿瘤细胞生物学实验室，国家肿瘤临床研究中心，教育部乳腺癌防治重点实验室，天津300060）

Author(s):
LIU Xiao-li;  HUANG Yong;  YANG Li-min;  YU Feng;  GU Feng ; MA Yong-jie
(Department of Tumor Cell Biology, Cancer Institute and Hospital ，Tianjin Medical University ；National Clinical Research Center

for Cancer； Key Laboratory of Breast Cancer Prevention and Therapy， Ministry of Education， Tianjin 300060，China)

关键词:
乳腺癌; 二氢嘧啶脱氢酶基因; 突变; 预后
Keywords:
breast cancer ;  dihydropyrimidine dehydrogenase gene;  mutation; prognosis
分类号:
R737.9
DOI:
-
文献标志码:
A
摘要:
目的：探讨二氢嘧啶脱氢酶基因(DPYD)的T85C和A1627G突变对浸润性乳腺癌患者生存的影响。方法：采用SPSS19.0软件进行统计学分析，使用临床资料完整的173例浸润性乳腺癌患者的石蜡包埋组织标本，检测并分析了DPYD基因编码序列的第85位点和第1627位点的核苷酸突变情况，并分析其与患者预后的关系。结果： T85C和A1627G位点联合突变与患者的淋巴结转移状态呈正相关。T85C和A1627G位点单突变对乳腺癌患者预后无影响，而与对照组相比，存在T85C和A1627G位点联合突变的乳腺癌患者预后较差，差异具有统计学意义。结论：中国乳腺癌患者中，DPYD基因T85C和A1627G联合突变与患者的淋巴结转移状态相关，且对患者预后具有重要影响，T85C和A1627G联合突变的患者预后较差。
Abstract:
Objective: To explore the prognostic effect of two mutations , T85C and A1627G of dihydropyrimidine dehydrogenase (DPYD)gene in invasive breast cancer. Methods: Paraffin-embedded specimens of 173 invasive breast cancer patients were sequenced and the nucleotide mutations at 85 and 1627 locus of DPYD gene coding sequence were detected. SPSS 19.0 software package was used to analysis the relationship between these two mutations and patients’ prognosis. Results: T85C combined with A1627G mutations showed a positive association with lymph node metastasis in breast cancer patients. T85C or A1627G single mutation was not correlated with prognosis of breast cancer patients. Patients with both T85C and A1627G mutations showed a worse prognosis compared with other patients. Conclusion: Combination of T85C with A1627G mutations in DPYD may have a positive association with lymph metastasis in Chinese invasive breast cancer patients. T85C combined with A1627G mutations indicates a worse prognosis.

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目(81272358)

作者简介 刘晓丽（1984-），女，医学检验技师，研究方向：恶性肿瘤的发生发展机制；

通信作者：马勇杰，yongjiemagu@aliyun.com。



更新日期/Last Update: 2016-09-19