[1] LIANG Y,ZHANG H,SONG X,et al. Metastatic heterogeneity of br-east cancer:molecular mechanism and potential therapeutic targets[J]. Semin Cancer Biol,2020,60:14-27.
[2] SIEGEL R L,MILLER K D,FUCHS H E,et al. Cancer statistics,2021[J]. CA Cancer J Clin,2021,71(1):7-33.
[3] VLASSOV A V,MAGDALENO S,SETTERQUIST R,et al. Exoso-mes:current knowledge of their composition,biological functions,and diagnostic and therapeutic potentials[J]. Biochim Biophys Acta,2012,1820(7):940-948.
[4] STEINBICHLER T B,DUDAS J,RIECHELMANN H,et al. The role of exosomes in cancer metastasis[J]. Semin Cancer Biol,2017,44:170-181.
[5] COLOMBO M,RAPOSO G,THERY C. Biogenesis,secretion,and intercellular interactions of exosomes and other extracellular vesicles[J]. Annu Rev Cell Dev Biol,2014,30:255-289.
[6] REZAIE J,AHMADI M,RAVANBAKHSH R,et al. Tumor-derived extracellular vesicles:the metastatic organotropism drivers[J]. Life Sci,2022,289:120216.
[7] AALTONEN N,KYYKALLIO H,TOLLIS S,et al. MCF10CA breast cancer cells utilize hyaluronan-coated EV-rich trails for coordinated migration[J]. Front Oncol,2022,12:869417.
[8] MATHIEU M,MARTIN-JAULAR L,LAVIEU G,et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication[J]. Nat Cell Biol,2019,21(1):9-17.
[9] YUE B,YANG H,WANG J,et al. Exosome biogenesis,secretion and function of exosomal miRNAs in skeletal muscle myogenesis[J]. Cell Prolif,2020,53(7):e12857.
[10] AHEGET H,TRISTAN-MANZANO M,MAZINI L,et al. Exosome:a new player in translational nanomedicine[J]. J Clin Med,2020,9(8):2380.
[11] GAJOS-MICHNIEWICZ A,DUECHLER M,CZYZ M. MiRNA in melanoma-derived exosomes[J]. Cancer Lett,2014,347(1):29-37.
[12] LI B,CAO Y,SUN M,et al. Expression,regulation,and function of exosome-derived miRNAs in cancer progression and therapy[J]. FASEB J,2021,35(10):e21916.
[13] SKOTLAND T,HESSVIK N P,SANDVIG K,et al. Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology[J]. J Lipid Res,2019,60(1):9-18.
[14] YU D,LI Y,WANG M,et al. Exosomes as a new frontier of cancer liquid biopsy[J]. Mol Cancer,2022,21(1):56.
[15] YANEZ-MO M,SILJANDER P R,ANDREU Z,et al. Biological pro-perties of extracellular vesicles and their physiological functions[J]. J Extracell Vesicles,2015,4:27066.
[16] ASHOUB M H,SALAVATIPOUR M S,KASGARI F H,et al. Extra-cellular microvesicles:biologic properties,biogenesis,and applications in leukemia[J]. Mol Cell Biochem,2023,Online ahead of print.
[17] STAHL A L,JOHANSSON K,MOSSBERG M,et al. Exosomes and microvesicles in normal physiology,pathophysiology,and renal diseases[J]. Pediatr Nephrol,2019,34(1):11-30.
[18] GEORGE J N,THOI L L,MCMANUS L M,et al. Isolation of human platelet membrane microparticles from plasma and serum[J]. Blood,1982,60(4):834-840.
[19] MARTINEZ M C,TESSE A,ZOBAIRI F,et al. Shed membrane microparticles from circulating and vascular cells in regulating vascular function[J]. Am J Physiol Heart Circ Physiol,2005,288(3):H1004-H1009.
[20] MENCK K,SIVALOGANATHAN S,BLECKMANN A,et al. Micro-vesicles in cancer:small size,large potential[J]. Int J Mol Sci,2020, 21(15):5373.
[21] MURALIDHARAN-CHARI V,CLANCY J W,SEDGWICK A,et al. Microvesicles:mediators of extracellular communication during cancer progression[J]. J Cell Sci,2010,123(Pt 10):1603-1611.
[22] KERR J F,WYLLIE A H,CURRIE A R. Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics[J]. Br J Cancer,1972,26(4):239-257.
[23] CRESCITELLI R,LASSER C,SZABO T G,et al. Distinct RNA profiles in subpopulations of extracellular vesicles:apoptotic bodies,microvesicles and exosomes[J]. J Extracell Vesicles,2013,2.
[24] SAVILL J,DRANSFIELD I,GREGORY C,et al. A blast from the past:clearance of apoptotic cells regulates immune responses[J]. Nat Rev Immunol,2002,2(12):965-975.
[25] WICKMAN G,JULIAN L,OLSON M F. How apoptotic cells aid in the removal of their own cold dead bodies[J]. Cell Death Differ,2012,19(5):735-742.
[26] LAMBERT A W,PATTABIRAMAN D R,WEINBERG R A. Emer-ging biological principles of metastasis[J]. Cell,2017,168(4):670-691.
[27] BOSMAN F T. Integrins:cell adhesives and modulators of cell function[J]. Histochem J,1993,25(7):469-477.
[28] MCCREADY J,SIMS J D,CHAN D,et al. Secretion of extracellular HSP90alpha via exosomes increases cancer cell motility:a role for plasminogen activation[J]. BMC Cancer,2010,10:294.
[29] KOUMANGOYE R B,SAKWE A M,GOODWIN J S,et al. Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading[J]. PLoS One,2011,6(9):e24234.
[30] MORTEZAEE K. Immune escape:a critical hallmark in solid tumo-rs[J]. Life Sci,2020,258:118110.
[31] CHOI S J,CHO H,YEA K,et al. Immune cell-derived small extracellular vesicles in cancer treatment[J]. BMB Rep,2022,55(1):48-56.
[32] RAIMONDO S,PUCCI M,ALESSANDRO R,et al. Extracellular vesicles and tumor-immune escape:biological functions and clinical perspectives[J]. Int J Mol Sci,2020,21(7):2286.
[33] YIN Y,CAI X,CHEN X,et al. Tumor-secreted miR-214 induces regulatory T cells:a major link between immune evasion and tumor growth[J]. Cell Res,2014,24(10):1164-1180.
[34] YU S,LIU C,SU K,et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells[J]. J Immunol,2007,178(11):6867-6875.
[35] ANDERSON N M,SIMON M C. The tumor microenvironment[J]. Curr Biol,2020,30(16):R921-R925.
[36] YOU B,PAN S,GU M,et al. Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation[J]. J Extracell Vesicles,2022,11(5):e12221.
[37] TOMINAGA N,KOSAKA N,ONO M,et al. Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier[J]. Nat Commun,2015,6:6716.
[38] TRIPATHI M,BILLET S,BHOWMICK N A. Understanding the role of stromal fibroblasts in cancer progression[J]. Cell Adh Migr,2012,6(3):231-235.
[39] DI MODICA M,REGONDI V,SANDRI M,et al. Breast cancer-secre-ted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers[J]. Cancer Lett,2017,384:94-100.
[40] DOGLIONI G,PARIK S,FENDT S M. Interactions in the(pre)me-tastatic niche support metastasis formation[J]. Front Oncol,2019,9:219.
[41] SCENEAY J,SMYTH M J,MOLLER A. The pre-metastatic niche:finding common ground[J]. Cancer Metastasis Rev,2013,32(3-4):449-464.
[42] KEKLIKOGLOU I,CIANCIARUSO C,GUC E,et al. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer mod-els[J]. Nat Cell Biol,2019,21(2):190-202.
[43] ZHOU W,FONG M Y,MIN Y,et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis[J]. Cancer Cell,2014,25(4):501-515.
[44] VANDER HEIDEN M G,CANTLEY L C,THOMPSON C B. Understanding the Warburg effect:the metabolic requirements of cell proliferation[J]. Science,2009,324(5930):1029-1033.
[45] NIU D,WU Y,LEI Z,et al. Lactic acid,a driver of tumor-stroma interactions[J]. Int Immunopharmacol,2022,106:108597.
[46] FONG M Y,ZHOU W,LIU L,et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis[J]. Nat Cell Biol,2015,17(2):183-194.
[47] KING H W,MICHAEL M Z,GLEADLE J M. Hypoxic enhancement of exosome release by breast cancer cells[J]. BMC Cancer,2012,12:421.
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