目的: 提高临床医生对Ⅰ型塑型性支气管炎(PB)的认识。方法: 采用回顾性病例分析方法对73例PB病人的临床资料进行分析。结果: 73例病例中男52例,女21例,男:女比为2.5:1;年龄10月~12岁,平均年龄(6.1±2.8)岁。所有病例均有发热,其中68例(占93.1%)高热,热程平均(13.9±7.6)d;咳嗽亦为主要表现,干咳65例(占89.0%)。胸部影像学显示不同表现,72例(占98.6%)为肺实变/肺不张;33例(占45.2%)合并胸腔积液,5例(占6.8%)合并肺气肿,2例(占2.7%)合并液气胸。15例(占20.5%)患者有呼吸困难,其中9例(占12.3%)出现低氧血症,2例(占2.7%)应用无创机械通气治疗。病原学检查发现66例(占90.4%)肺炎支原体(MP)阳性,有43例(占58.9%)存在混合感染,7例(占9.6%)为其他病原体感染。所有患者外周血常规无特征性改变,65例患者(占89.0%)LDH升高,57例(占78.1%)ESR增快,56例(占76.7%)CRP升高,64例(占87.6%)IL-6升高,45例(占61.6%)D-二聚体升高。所有患儿均于入院后1~9 d(病程5~33 d)行纤维支气管镜检查,镜下发现病变部位支气管可见灰白色分泌物栓塞,栓塞物经病理诊断均为Ⅰ型PB。所有病例均以临床好转或治愈出院,平均住院(10.1±4.1)d。结论: MP感染是儿童Ⅰ型PB的主要病原体,持续高热及影像学进展的病人,应警惕PB发生,及早行纤维支气管镜治疗。
?
[1]焦安夏,马渝燕,饶小春,等.儿童肺炎支原体肺炎细菌性肺炎致塑型性支气管炎15例临床分析[J].中国证儿科杂志,2010,5(4):294
[2]辛毅,王郜,刘靖,等.儿童肺炎致塑性支气管炎36例[J]. 中华实用儿科临床杂志,2015,30(22):1746
[3]王文磊,李芳.[J].重庆医学,2016,45(32):4490
[4]编辑委员会.儿童社区获得性肺炎管理指南[J].中华儿科杂志,2013,51(10):745
[5]编辑委员会.儿童肺炎支原体肺炎诊治专家共识[J].中华实用儿科临床杂志,2015,30(17):1304
[6]Seear M, Hui H, Magee F, et al. Bronchial casts in children: a proposed classification based on nine cases and a review of the literature[J].Am J Respir Crit Care Med,1997,155(1):364
[7]Jasinovic T, Kozak F K, Moxham J P, et al. Casting a look at pediatric plastic bronchitis[J].Int J Pediatr Otorhinolaryngol, 2015,79 (10):1658
[8]Kunder R, Kunder C, Sun H Y, et al. Pediatric plastic bronchitis: case report and retrospective comparative analysis of epidemiology and pathology[J].Case Rep Pulmonol,2013(4):649365
[9]Turgut T, In E, ?zercan I H, et al. A case of plastic bronchitis[J].Arch Iran Med,2014,17(8):589
[10]Schumacher K R, Singh T P, Kuebler J, et al. Risk factors and outcome of Fontan-associated plastic bronchitis: a case-control study[J].J Am Heart Assoc,2014,22(2):e000865
[11]Do P, Randhawa I, Chin T, et al. Successful management of plastic bronchitis in a child post fontan: case report and literature review[J].Lung,2012,190(4):463
[12]丁小芳,钟礼立,张兵,等.儿童塑型性支气管炎9例临床特征及病原学分析[J].中国当代儿科杂志,2014,16(7):729
[13]Garcia-Henriquez N, Toloza E M, Khalil F, et al. Extensive plastic bronchitis: etiology of a rare condition[J].J Thorac Dis,2016, 8(9):E961
[14]Madsen P, Shah S A, Rubin B K. Plastic bronchitis: new insights and a classification scheme[J].Paediatr Respir Rev,2005,6(4):292
[15]陈进喜,林业辉,高豆豆.儿童塑型性支气管炎10例临床分析[J].海南医学,2015,26(14):2141
[16]卢志威,邓继岿,郑跃杰,等.儿童塑型性支气管炎24例[J].中实用儿科临床杂志,2013,28(4):265
[17]Nogan S J, Cass N D, Wiet G J, et al. Plastic bronchitis arising from solitary influenza B infection: A report of two cases in children[J]. Int J Pediatr Otorhinolaryngol,2015,79(7):1140
[18]Oikawa J, Ogita J, Ishiwada N, et al. Human bocavirus DNA detected in a boy with plastic bronchitis[J].Pediatr Infect Dis J,2009,28(11):1035
[19]Eberlein M H, Drummond M B, Haponik E F. Plastic bronchitis: a management challenge[J].Am J Med Sci,2008,335(2):163
[1]王 凊,车绪春.调节性T细胞获得及其免疫抑制作用的实验研究[J].天津医科大学学报,2015,21(05):393.
WANG Qing,CHE Xu-chun.Study on iTreg cells obtaining method and its immunosuppression function [J].Journal of Tianjin Medical University,2015,21(05):393.
[2]陈晓鹏,胡永成,方 成,等.血红素氧化酶1在ADSCs增殖、凋亡和成骨分化的作用[J].天津医科大学学报,2015,21(05):379.
CHEN Xiao-peng,HU Yong-cheng,FANG Cheng,et al. Effect of proliferation, apoptosis and osteogenic differentiation of ADSCs transduced with heme oxygenase-1? [J].Journal of Tianjin Medical University,2015,21(05):379.
[3]刘 磊,李彦生,俞浩楠,等.11C左旋间羟基麻黄素制备方法的优化及改进[J].天津医科大学学报,2015,21(05):441.
LIU Lei,LI Yan-sheng,YU Hao-nan,et al.Optimization and improvement of production of (-)-[11C]meta-Hydroxyephedrine[J].Journal of Tianjin Medical University,2015,21(05):441.
[4]李 冰,冯 凭.罗格列酮干预糖尿病大鼠脂肪组织CMKLR1及Chemerin基因表达[J].天津医科大学学报,2015,21(06):484.
LI Bing,FENG Ping.Effect of rosiglitazone on the expression of CMKLR1 and Chemerin mRNA in the adipose tissue of diabetic rat[J].Journal of Tianjin Medical University,2015,21(05):484.
[5]LI Yan-ping,CHAI Yan-fen.?连续血液滤过对严重脓毒症患者部分炎性指标及器官功能的影响 [J].天津医科大学学报,2015,21(06):491.
LI Yan-ping,CHAI Yan-fen.?Effect of continuous hemofiltration on inflammatory mediators and organ function in severe sepsis[J].Journal of Tianjin Medical University,2015,21(05):491.
[6]孟昀,张华,于泳浩.右美托咪定对老年腹腔镜手术患者脑氧饱和度及术后认知功能的影响[J].天津医科大学学报,2016,22(01):66.
MENG Yun,ZHANG Hua,YU Yong-hao?.Effect of dexmedetomidine on cerebral oxygen saturation and cognitive function in elder patients during laparoscopic surgery [J].Journal of Tianjin Medical University,2016,22(05):66.
[7]李宏亮,刘 彤,许 纲,等.红细胞分布宽度与阵发性非瓣膜性心房颤动射频消融复发的关系[J].天津医科大学学报,2016,22(02):104.
LI Hong-liang,LIU Tong,XU Gang,et al.Association between RDW and atrial fibrillation recurrence after radiorequency catheter ablation in patients with paroxysmal non-valvular atrial fibrillation[J].Journal of Tianjin Medical University,2016,22(05):104.
[8]刘超,韩雅婷,杨 冰,等.基础医学模式生物酿酒酵母接合型的鉴定—PCR法[J].天津医科大学学报,2016,22(03):256.
LIU Chao,HAN Ya-ting,YANG Bing,et al.Identification of the mating-type of model organism S. cerevisiae in basic medical science by PCR[J].Journal of Tianjin Medical University,2016,22(05):256.
[9]李立楠,李杉杉,刘 悦,等.神经酰胺诱导LX-2细胞凋亡抑制肝纤维发生的作用[J].天津医科大学学报,2016,22(04):283.
LI Li-nan,LI Shan-shan,LIU Yue,et al.Effects of ceramide on promoted LX-2 cell apoptosis and inhibitting hepatic fibrosis[J].Journal of Tianjin Medical University,2016,22(05):283.
[10]王 锐,高靖达,张 卫,等.索利那新联合三联药物膀胱灌注治疗间质性膀胱炎/膀胱疼痛综合征疗效分析[J].天津医科大学学报,2016,22(04):341.