|本期目录/Table of Contents|

[1]陈 辉,樊茹佳,丁继侠.宫颈癌组织中Foxm1、ANGPTL4蛋白表达及临床意义[J].天津医科大学学报,2019,25(05):510-513.
　CHEN Hui,FAN Ru-jia,DING Ji-xia.Expression and clinical significance of Foxm1 and ANGPTL4 protein in cervical cancer tissues[J].Journal of Tianjin Medical University,2019,25(05):510-513.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年05期
页码:
510-513
栏目:
临床医学
出版日期:
2019-09-20

文章信息/Info

Title:
Expression and clinical significance of Foxm1 and ANGPTL4 protein in cervical cancer tissues
文章编号:
1006-8147(2019)05-0510-04
作者:
陈 辉1; 樊茹佳2; 丁继侠1
（1. 河南工业大学医院妇科，郑州450001；2.河南省人民医院妇产科，郑州 450003）
Author(s):
CHEN Hui1; FAN Ru-jia2; DING Ji-xia1
（1. Department of Obstetrics and Gynecology, Henan University of Technology Hospital, Zhengzhou 450001, China; 2. Department of Obstetrics and Gynecology, Henan People’s Hospital, Zhengzhou 450003, China）
关键词:
宫颈癌; Foxm1; ANGPTL4; 临床意义
Keywords:
cervical cancer;  Foxm1;  ANGPTL4;  clinical significance
分类号:
R737.33
DOI:
-
文献标志码:
A
摘要:
目的：探讨宫颈癌组织中Foxm1、ANGPTL4蛋白表达及临床意义。方法：选取2017年1月-2018年3月河南省人民医院保存的宫颈癌组织标本72例，同时选取正常宫颈组织标本35例作为对照组，采用免疫组化检测Foxm1、ANGPTL4蛋白表达水平。结果：宫颈癌组织Foxm1和ANGPTL4蛋白阳性表达率为63.89%和75.00%，明显高于对照组（P＜0.05）；FIGO分期Ⅱ期、肌层浸润≥1/2、中低分化宫颈癌Foxm1蛋白阳性表达率分别为89.47%、84.62%和79.07%，明显高于Ⅰ期、肌层浸润＜1/2、高分化患者（P＜0.05）；有脉管浸润宫颈癌ANGPTL4蛋白阳性表达率为95.24%，明显高于无脉管浸润（P＜0.05）；Foxm1与ANGPTL4蛋白表达呈正相关（rs=0.301，P＜0.05）。结论：宫颈癌组织中Foxm1、ANGPTL4蛋白呈高表达，在疾病发生发展中可能有重要作用。
Abstract:
Objective: To investigate the expression and clinical significance of Foxm1 and ANGPTL4 in cervical cancer. Methods:From January 2017 to March 2018, 72 specimens of cervical cancer and 35 specimens of normal cervical tissue were selected as controls; the expression of Foxm1 and ANGPTL4 protein was detected by immunohistochemical staining. Results: The positive rates of Foxm1 and ANGPTL4 protein in cervical cancer tissues were 63.89% and 75.00%, which were significantly higher than those in the control group(P< 0.05); The positive expression rates of Foxm1 protein in stage II, myometrial invasion ≥ 1/2， and moderately and poorly differentiated cervical cancer were 89.47%, 86.84% and 79.07% respectively, which were significantly higher than those in stage I, myometrial invasion <1/2 and well differentiated patients(P<0.05); The positive expression rate of ANGPTL4 protein in cervical carcinoma with vascular invasion was 95.24%, which was significantly higher than that without vascular invasion(P<0.05); We found a positive correlation between Foxm1 and ANGPTL4 protein expression(rs=0.301, P < 0.05). Conclusion: Foxm1 and ANGPTL4 proteins are highly expressed in cervical cancer tissues, and may play an important role in the development of diseases.

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备注/Memo

备注/Memo:
基金项目 2016年度河南省医学科技攻关计划项目（201602184）
作者简介 陈辉（1979-），女，主治医师，硕士，研究方向：妇产科；通信作者：樊茹佳，E-mail:fanrujia@126.com。
更新日期/Last Update: 2019-10-11