|本期目录/Table of Contents|

[1]胡 杨 综 述,吴雄志 审 校.特异性蛋白转录因子1在乳腺癌中的研究进展[J].天津医科大学学报,2019,25(02):184.
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特异性蛋白转录因子1在乳腺癌中的研究进展(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年02期
页码:
184
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2019)02-0184-05
作者:
胡 杨 综 述吴雄志 审 校
(天津医科大学肿瘤医院中医科,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心,天津300060)
Author(s):
-
关键词:
Sp1乳腺癌凋亡转移
Keywords:
-
分类号:
R737.9
DOI:
-
文献标志码:
A
摘要:
随着乳腺癌发病率的不断提高,寻找新的治疗靶点成为当今的研究热点。特异性蛋白转录因子1( Sp1)作为Sp/Kruppel样锌指转录因子家族中的一员,已被证明能够调节多种与乳腺癌生长和转移相关的癌基因的表达。笔者将围绕Sp1的结构特点以及其在乳腺癌发生发展中的分子机制进行综述,为寻找乳腺癌新的治疗方式提供理论依据。
Abstract:
-

参考文献/References:


[1] Rocha-Brischiliari S C, Oliveira R R, Andrade L, et al. The Rise in Mortality from Breast Cancer in Young Women: Trend Analysis in Brazil[J]. PLoS One, 2017,12(1):e168950
[2] Zhao Y, Liu Y. A mechanistic overview of herbal medicine and botanical compounds to target transcriptional factors in Breast cancer[J]. Pharmacol Res, 2017, [Epub ahead of print]
[3] Marin M, Karis A, Visser P, et al. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation[J]. Cell, 1997,89(4):619
[4] Beishline K, Azizkhan-Clifford J. Sp1 and the 'hallmarks of cancer'[J]. FEBS J, 2015,282(2):224
[5] Safe S, Abbruzzese J L, Abdelrahim M, et al. Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development[J]. Cancer Prev Res (Phila), 2018 , [Epub ahead of print]
[6] Cawley S, Bekiranov S, Ng H H, et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs[J]. Cell, 2004, 116(4):499
[7] Marin M, Karis A, Visser P, et al. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation[J]. Cell, 1997,89(4):619
[8] Mauro L, Pellegrino M, Giordano F, et al. Estrogen receptor-alpha drives adiponectin effects on cyclin D1 expression in breast cancer cells[J]. FASEB J, 2015,29(5):2150
[9] Biggs J R, Kudlow J E, Kraft A S. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells[J]. J Biol Chem, 1996,271(2):901
[10] Wei M, Liu B, Gu Q, et al. Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1)[J]. Cell Oncol (Dordr), 2013,36(1):79
[11] Wei M, He Q, Yang Z, et al. Integrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone[J]. BMC Cancer, 2014,14(10):10
[12] Kim M K, Jeon B N, Koh D I, et al. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding[J]. J Biol Chem, 2013,288(10):7053
[13] Zhang Y, Zhao Y, Li L, et al. The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast cancer cells[J]. Biochem Biophys Res Commun, 2013,434(2):305
[14] Yue L, Li L, Liu F, et al. The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells[J]. Carcinogenesis, 2013,34(4):927
[15] Werner H, Sarfstein R. Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer[J]. Growth Horm IGF Res, 2014,24(4):112
[16] Schacter J L, Henson E S, Gibson S B. Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells[J]. PLoS One, 2014,9(6):e100364
[17] Jia Z, Gao S, M'Rabet N, et al. Sp1 is necessary for gene activation of Adamts17 by estrogen[J]. J Cell Biochem, 2014,115(10):1829
[18] Yang W S, Chadalapaka G, Cho S G, et al. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis[J]. Neoplasia, 2014,16(12):1059
[19] Yao Y, Hu J, Shen Z, et al. MiR-200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting Sp1[J]. J Cell Mol Med, 2015,19(4):760
[20] Cheng H T, Hung W C. Inhibition of lymphangiogenic factor VEGF-C expression and production by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in breast cancer cells[J]. Oncol Rep, 2013,29(3):1238
[21] Zhao Y, Ma J, Fan Y, et al. TGF-beta transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways[J]. Mol Oncol, 2018,12(3):305
[22] Kong L M, Liao C G, Zhang Y, et al. A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis[J]. Cancer Res, 2014,74(14):3764
[23] Bajpai R, Nagaraju G P. Specificity protein 1: Its role in colorectal cancer progression and metastasis[J]. Crit Rev Oncol Hematol, 2017, 113(6):1
[24] Nam K, Oh S, Lee K M, et al. CD44 regulates cell proliferation, migration, and invasion via modulation of c-Src transcription in human breast cancer cells[J]. Cell Signal, 2015,27(9):1882
[25] Tarasewicz E, Oakes R S, Aviles M O, et al. Embryonic stem cell secreted factors decrease invasiveness of triple-negative breast cancer cells through regulome modulation[J]. Cancer Biol Ther, 2018,19(4):271
[26] Kwon Y J, Baek H S, Ye D J, et al. CYP1B1 Enhances cell proliferation and metastasis through induction of EMT and activation of Wnt/beta-catenin signaling via Sp1 upregulation[J]. PLoS One, 2016, 11(3):e151598
[27] Nam E H, Lee Y, Zhao X F, et al. ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin alpha5 expression[J]. Carcinogenesis, 2014,35(2):302
[28] Zu X, Zhong J, Tan J, et al. TGF-beta1 induces HMGA1 expression in human breast cancer cells: implications of the involvement of HMGA1 in TGF-beta signaling[J]. Int J Mol Med, 2015,35(3):693
[29] Lu J, Isaji T, Im S, et al. beta-Galactoside alpha2,6-sialyltranferase 1 promotes transforming growth factor-beta-mediated epithelial-mesenchymal transition[J]. J Biol Chem, 2014,289(50):34627
[30] Kuo T C, Tan C T, Chang Y W, et al. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility[J]. J Clin Invest, 2013, 123(3):1082
[31] Liu R, Zhi X, Zhou Z, et al. Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Kruppel-like factor 5 transcription by Sp1[J]. Sci Rep, 2018,8(1):1138
[32] Wu X G, Peng S B, Huang Q. Transcriptional regulation of breast cancer resistance protein[J]. Yi Chuan, 2012,34(12):1529
[33] Saha S, Mukherjee S, Mazumdar M, et al. Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin[J]. Transl Res, 2015,165(5):558
[34] Sankpal U T, Maliakal P, Bose D, et al. Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy[J]. Curr Med Chem, 2012,19(22):3779
[35] Liu X, Abdelrahim M, Abudayyeh A, et al. The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression[J]. Mol Cancer Ther, 2009,8(5):1207
[36] Chuang C W, Pan M R, Hou M F, et al. Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells[J]. J Cell Physiol, 2013,228(2):341
[37] Banerjee N, Talcott S, Safe S, et al. Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation[J]. Breast Cancer Res Treat, 2012,136(1):21
[38] Gu G, Barone I, Gelsomino L, et al. Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERalpha/Sp1-mediated p53 activation[J]. J Cell Physiol, 2012,227(10):3363
[39] Kang T H, Seo J H, Oh H, et al. Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells[J]. J Cell Biochem, 2017,118(12):4652
[40] Zhu Y, Yao Z, Wu Z, et al. Role of tumor necrosis factor alpha-induced protein 1 in paclitaxel resistance[J]. Oncogene, 2014,33(25):3246

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目(81473441) 作者简介 胡杨(1993-),女,硕士在读,研究方向:抗癌中草药临床及基础研究;通信作者:吴雄志,E-mail:wuxiongzhi@163.com。
更新日期/Last Update: 2019-04-25