«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年03期

页码:

221-224

栏目:

临床医学

出版日期:

2017-05-18

文章信息/Info

Title:

Correlation of severity of chronic heart failure with plasma homocysteine level

文章编号:

1006-8147(2017)03-0221-04

作者:

徐西子; 董昭杰; 马向红

（天津医科大学第二医院心脏科， 天津 300211）

Author(s):

XU Xi-zi ; DONG Zhao- jie; MA Xiang-hong

(Department of Cardiology, The Second Hospital , Tianjin Medical University, Tianjin 300211, China)

关键词:

冠心病; 心力衰竭; 同型半胱氨酸

Keywords:

coronary heart diseases ; chronic heart failure;  homocysteine

分类号:

R541,6+1

DOI:

-

文献标志码:

A

摘要:

目的：观察同型半胱氨酸（Hcy）水平与冠心病慢性心力衰竭(CHF)严重程度的相关性。方法：连续纳入 CHF 84例,按NYHA分级分为3个亚组：Ⅱ级组（n=36）、Ⅲ级组（n=28）、Ⅳ级组（n=20）；并纳入同期住院的25例无心衰的心绞痛患者（CHD组）作为对照组；分别比较CHF组和CHD组及CHF各亚组间Hcy与氮末端脑钠肽(nt-proBNP)、左室射血分数（LVEF）、左室舒张末直径（LVEDD）的差异及相关性。结果：(1)CHF组患者Hcy水平显著高于CHD组，且Hcy水平随心衰分级的增加而增加,各组间差异有统计学意义（P<0.05）。(2)Hcy与nt-proBNP、LVEDD呈正相关(r= 0.51,P< 0.05; r= 0.43,P< 0.05)，与LVEF%呈负相关(r=-0.42,P< 0.05)。结论：Hcy水平与CHF 的严重程度有关，并且随着心衰分级的增加而增加。

Abstract:

O bjective: To observe the correlation between the serum homocysteine（Hcy）level and the severity of chronic heart failure（CHF） in patients with coronary heart diseases（CHD）. Methods: CHF patients (n=84) were chosen continuously as CHF group and other patients diagnosed as angina without CHF (n=25) were chosen at the same time as control group . CHF group was divided again into II-grade subgroup (n=36), III-grade subgroup (n=28) and IV-grade subgroup (n=20) according to NYHA grading method. The differences in levels of Hcy and nt-proBNP were analyzed between CHF group and control group and among all subgroups. The correlations between Hcy and nt-pro BNP, left ventricular ejection fraction (LVEF) , left ventricular end-diastolic diameter(LVEDD) were studied. Results:（1）The serum levels of Hcy in CHF group were higher than those in CHD group，as the increase of NYHA grade, the levels of Hcy increased significantly (P<0.05). (2)The level of Hcy was correlated positively with nt-pro BNP and LVEDD (r=0.51,P<0.05;r=0.43,P<0.05) and correlated negative with LVEF (r=-0.42,P<0.05). Conclusion: The serum Hcy level may reflect the severity of CHF and increase with the severity degree of CHF .

参考文献/References:

[1]Petras M, Tatarkova Z, Kovalska M, et al. Hyperhomocysteinemia as a risk factor for the neuronal system disorders[J]. J Physiol Pharmacol, 2014, 65(1): 15

[2]Keshteli A H, Baracos V E, Madsen K L. Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: a review[J]. World J Gastroenterol, 2015, 21(4): 1081

[3]Tekin AS, Sengul C, KillcaslanB, et al.The value of serum homocysteine in predicting one-year survival in patients with severe systolic heart failure[J].Turk Kardiyol Dern Ars,2012，40(8):699

[4]Agoston-Coldea L, Mocan T, GatfosseM,et al. Plasma homocysteine and the severity of heart failure in patients with the previous myocardial infarction [J]. Cardiol J, 2011,18(1):55

[5]Kerrmann M, Kindermann I, Muller S ,et al. Relationship of plasma homocysteine with the severity of chronic heart failure[J].Clin Chem, 2005,51(8):1512

[6] Chen F Y, Guo Y H, Gao W, et al. Effects of hyperhomocysteinemia on cardiac remodeling in rats[J]. Beijing Da Xue Xue Bao， 2006 ，38(2):179

[7]Tawakol A, Forgione MA, Stuehlinger M, et al. Homocysteine impairs coronary microvascular dilator function in humans[J]. J Am Coll Cardiol,2002,40:1051

[8] Su S J, Huang L W, Pai LS, et al. Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression[J]. Nutrition ,2005, 21（10）:994

[9]郎娟,覃玉群,赵建军. 大鼠脑微血管内皮细胞的原代培养与鉴定［Ｊ］.健康研究，20011,31（6）：407

[10] Zivkovic V, Jakovljevic V, Djordjevic D, et al. The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart [J]. Mol Cell Biochemistry, 2012, 370(1/2): 59

[11] Kalela A, Koivu TA, Sisto T, el al. Serum matrixmetalloproteinase-9 concentration in angiographically assessed coronary artery disease[J]. Scand J Clin Lab Invest, 2002, 62(5):337

[12] Mishra P K, Tyagi N, Kundu S, et al. MicroRNAs are involved in homocysteine-induced cardiac remodeling[J]. Cell Biochem Biophys , 2009,55(3): 153

[13] Pankaj C，Anuradha K，Srikanth G，et al. Differential regulation of DNA methylation versus histone acetylation in cardiomyocytes during HHcy in vitro and in vivo： An epigenetic mechanism[J]. Physiol Genomics，2014，46（7）：245

[14]Narayanan N, Tyagi N, Shah A,et al. Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics[J]. Int J Physiol Pathophysiol Pharmacol , 2013, 5(1): 32

相似文献/References:

[1]陈 云,袁如玉,阎哲慧,等.动态动脉硬化指数对原发性高血压患者冠心病的预测价值[J].天津医科大学学报,2013,19(06):468.
　CHEN Yun,YUAN Ru-yu,YAN Zhe-hui,et al.Predictive value of ambulatory arterial stiffness index for coronary heart disease in primary hypertensive patients[J].Journal of Tianjin Medical University,2013,19(03):468.
[2]蒋森森,周长钰.平均血小板体积、红细胞分布宽度与冠心病的相关性研究[J].天津医科大学学报,2014,20(02):120.
　JIANG Sen-sen,ZHOU Chang-yu.Correlation between mean platelet volume, red blood cell distribution width and coronary heart disease [J].Journal of Tianjin Medical University,2014,20(03):120.
[3]巩江华,周长钰.RT-3DE在评价冠状动脉病变中的价值[J].天津医科大学学报,2014,20(02):131.
　GONG Jiang-hua,ZHOU Chang-yu.Evaluation of coronary artery stenosis by using real-time three-dimensional echocardiography[J].Journal of Tianjin Medical University,2014,20(03):131.
[4]谭艳萍,吴校伟,刘 寅,等. 冠心病合并糖尿病患者药物涂层支架术后观察[J].天津医科大学学报,2014,20(05):414.
[5]李佳丽,姚朱华,马 梅,等.冠心病合并阻塞性睡眠呼吸暂停低通气综合征临床分析[J].天津医科大学学报,2014,20(06):472.
[6]刘洪梅综述,李广平审校. 血清胆红素在冠心病患者中的应用价值研究进展[J].天津医科大学学报,2014,20(06):506.
[7]刘 瑞,刘玉洁,何 乐.CETP TaqIB基因多态性与血脂及冠心病相关性研究[J].天津医科大学学报,2015,21(02):117.
　LIU Rui,LIU Yu-jie,HE Le.Studies on the correlation between CETP TaqIB gene polymorphism and blood lipid and coronary heart disease[J].Journal of Tianjin Medical University,2015,21(03):117.
[8]李文军,刘相丽,孙丽丽,等.血清胱抑素C在急性冠脉综合征中的预测价值[J].天津医科大学学报,2015,21(03):189.
　LI Wen-jun,LIU Xiang-li,SUN Li-li,et al.Prediction value of plasma cystatin C level in patients with acute coronary syndrome[J].Journal of Tianjin Medical University,2015,21(03):189.
[9]赵艳辉,丛洪良.心衰患者血清胱抑素C、嗜铬粒蛋白A与心室重构的关系[J].天津医科大学学报,2015,21(03):193.
　ZHAO Yan-hui,CONG Hong-liang.Relationship between the serum cystatin C, chromaffin grain protein A and the ventricular remodeling in patients with chronic heart failure[J].Journal of Tianjin Medical University,2015,21(03):193.
[10]刘先锋,张 晶,丛洪良.血浆同型半胱氨酸水平与传统冠心病危险因素关系及对冠心病进展的作用[J].天津医科大学学报,2016,22(04):343.
[11]彭云玲,齐 新,魏丽萍,等.冠心病心力衰竭患者心率变异性分析[J].天津医科大学学报,2014,20(05):363.
　PENG Yun-ling,QI Xin,WEI Li-ping,et al.Analysis on heart rate variability in heart failure patients with coronary heart disease[J].Journal of Tianjin Medical University,2014,20(03):363.

备注/Memo

备注/Memo:

作者简介 徐西子（1990-），女，硕士在读,研究方向 ：心血管内科 ；通信作者：马向红,E-mail:ma_xianghong@163.com。

常用功能

更新日期/Last Update: 2017-05-18