|本期目录/Table of Contents|

[1]刘先锋,张 晶,丛洪良.血浆同型半胱氨酸水平与传统冠心病危险因素关系及对冠心病进展的作用[J].天津医科大学学报,2016,22(04):343-346.
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血浆同型半胱氨酸水平与传统冠心病危险因素关系及对冠心病进展的作用(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年04期
页码:
343-346
栏目:
临床医学
出版日期:
2016-07-19

文章信息/Info

Title:
-
文章编号:
1006-8147（2016）04-0343-04
作者:
刘先锋1 ; 张 晶2 ; 丛洪良2
（1．天津医科大学研究生院，天津 300070；2.天津市胸科医院心内科，天津300350）
Author(s):
-
关键词:
冠心病; 同型半胱氨酸; 冠状动脉粥样硬化
Keywords:
-
分类号:
R541.4
DOI:
-
文献标志码:
A
摘要:
目的：探讨血浆同型半胱氨酸（HCY）水平与传统冠心病危险因素的关系及其与传统冠心病危险因素共同对冠状动脉粥样硬化的影响。方法：分别测964例入院患者血浆HCY、总胆固醇水平，并调查年龄、性别、高血压、糖尿病、吸烟等其他传统冠心病危险因素，同时根据冠脉造影结果计算冠状动脉粥样硬化患者的冠脉Gensini积分以反映冠状动脉粥样硬化的程度，以分析冠心病传统危险因素对血浆HCY的影响及其二者共同对冠心病发生发展的影响。结果：男性血浆HCY水平[（15.57±8.43） mmol/L]明显高于女性[（12.74±7.18） mmol/L]，高血压患者、吸烟、高胆固醇血症患者明显较对照组血浆HCY水平高，并且具有统计学意义（P均＜0.05），而糖尿病患者与对照组血浆HCY水平的差异无统计学意义。血浆HCY水平与年龄呈正相关（rs=0.119，P＜0.001）。Logistic回归分析表明性别、高血压、吸烟、胆固醇及年龄是血浆HCY水平升高的影响因素，而糖尿病对HCY的影响无统计学意义。Logistic回归表明HCY不是冠心病发病的独立危险因素（P=0.837），但HCY与男性、高血压、吸烟、胆固醇、甘油三酯对冠状动脉粥样程度的影响有协同作用（均P <0.05），而与女性、糖尿病的协同作用无统计学意义（P =0.089，P =0.263）。结论：男性、高龄、高血压、吸烟、胆固醇引起血浆HCY水平升高，HCY不是冠心病发病的独立危险因素，但与男性、高血压、吸烟、胆固醇共同促进冠心病的进展，而与女性及糖尿病无协同促进作用。
Abstract:
-

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备注/Memo

备注/Memo:
基金项目 天津市卫生局科技基金项目（13KG133）

作者简介 刘先锋（1986-），男，硕士在读，临床心血管病学；通信作者：张晶 yuyinliuxiang@163.com。

更新日期/Last Update: 2016-07-13