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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

26卷

期数:

2020年02期

页码:

163-165,174

栏目:

临床医学

出版日期:

2020-04-30

文章信息/Info

Title:

The value of methylthioadenosine and plasma heparin-binding protein in early diagnosis and mortality risk assessment of neonatal sepsis

文章编号:

1006-8147(2020)02-0166-06

作者:

郑浩; 逯自明; 庞萌

（河南省平顶山市第一人民医院检验科，平顶山 467000）

Author(s):

ZHENG Hao;  LU Zi-ming;  PENG Meng

（Clinical Laboratory, The First People’s Hosptal of Pingdingshan, Pingdingshan 467000, China）

关键词:

脓毒症; 甲硫腺苷; 肝素结合蛋白; 早期诊断; 死亡风险评估

Keywords:

sepsis;  methylthioadenosine;  heparin binding protein;  early diagnosis;  risk assessment of death

分类号:

R722.13

DOI:

-

文献标志码:

A

摘要:

目的：探讨甲硫腺苷（MTA）、肝素结合蛋白（HBP）在脓毒症早期诊断及死亡风险评估中的临床应用价值。方法：选取健康体检者 40名、局部感染患儿40例、脓毒症患儿45例、重症脓毒症患儿40例、脓毒症休克患儿35例，测定各组患者血清MTA及HBP水平，并分析血清MTA及HBP水平与新生儿脓毒症严重程度的关系以及对死亡风险预测的准确率。结果：脓毒症休克组 MTA、HBP 水平明显高于健康对照组、局部感染组、脓毒症组及重症脓毒症组，差异均有统计学意义（均P＜0.05）。并且随着脓毒症的加重，APACHE Ⅱ评分也逐渐升高。MTA和HBP联合诊断脓毒症的效能明显高于MTA和HBP单指标的诊断效能。死亡组血清MTA及HBP水平明显高于存活组，血清MTA及HBP水平在预测脓毒血症死亡风险的准确率与目前广泛用于医院的APACHE Ⅱ评分类似。结论：MTA及HBP是脓毒症早期诊断的有效标志物，MTA及HBP联合检测有助于脓毒症的早期诊断，MTA及HBP的持续升高预示脓毒症新生儿死亡风险较高。

Abstract:

Objective: To investigate the clinical value of methylthioadenosine (MTA) and heparin binding protein(HBP) in the early diagnosis and mortality risk assessment of sepsis. Methods： Forty healthy subjects, 40 patients with local infection, 45 patients with sepsis, 40 patients with severe sepsis, and 35 patients with septic shock were enrolled. Serum MTA and HBP levels were measured . The relationship between serum MTA and HBP levels and the severity of neonatal sepsis, and the accuracy of mortality risk prediction was analyzed. Results：The levels of MTA and HBP in septic shock group were significantly higher than those in healthy control group, local infection group, sepsis group and severe sepsis group(all P<0.05). And with the aggravation of sepsis, the APACHE Ⅱscore also gradually increased. The combined efficacy of MTA and HBP in the diagnosis of sepsis was significantly higher than the diagnostic efficacy of MTA and HBP single indicators. Serum MTA and HBP levels in the death group were significantly higher than in the survival group. The accuracy of serum MTA and HBP levels in predicting the risk of sepsis death was similar to the APACHE Ⅱ score currently widely used in hospitals. Conclusion：MTA and HBP are effective markers for the early diagnosis of sepsis. The combined detection of MTA and HBP is helpful for the early diagnosis of sepsis. The continuous elevation of MTA and HBP indicates a higher risk of death in neonates with sepsis.

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备注/Memo

备注/Memo:

作者简介 郑浩（1985-），男，主管技师，研究方向：临床生物化学检验及肿瘤免疫学诊断；E-mail:jms20160722@126.com。

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更新日期/Last Update: 2020-06-02