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[1]饶红萍,李易娟.脂多糖结合蛋白联合降钙素原、白细胞介素-6对胎膜早破早产儿细菌感染的早期诊断价值[J].天津医科大学学报,2020,26(02):158-162,174.
 RAO Hong-Ping,LI Yi-Juan.Early diagnostic value of lipopolysaccharide binding protein combined with procalcitonin and interleukin -6 on the bacterial infection of preterm infants with premature rupture of membranes[J].Journal of Tianjin Medical University,2020,26(02):158-162,174.
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脂多糖结合蛋白联合降钙素原、白细胞介素-6对胎膜早破早产儿细菌感染的早期诊断价值(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年02期
页码:
158-162,174
栏目:
临床医学
出版日期:
2020-04-30

文章信息/Info

Title:
Early diagnostic value of lipopolysaccharide binding protein combined with procalcitonin and interleukin -6 on the bacterial infection of preterm infants with premature rupture of membranes
文章编号:
1006-8147(2020)02-0163-04
作者:
饶红萍1李易娟2
(1.惠州市中心人民医院,惠州 516001;2.中山大学附属第一医院,广州 510080)
Author(s):
RAO Hong-Ping1 LI Yi-Juan2
(1. Department of Neonatology, Cenrtral People’s Hospital of Huizhou City , Huizhou 516001, China;2. Department of Pediatrics, The First Affiliated Hospital ,Zhongshan University,Guangzhou 510080, China)
关键词:
脂多糖结合蛋白降钙素原白细胞介素-6胎膜早破早产儿细菌性感染
Keywords:
lipopolysaccharide binding proteinprocalcitonin interleukin-6premature rupture of membranespremature infant bacterial infection
分类号:
R722.6
DOI:
-
文献标志码:
A
摘要:
目的:评估脂多糖结合蛋白(LBP)、降钙素原(PCT)和白细胞介素-6(IL- 6)在胎膜早破(PROM)合并细菌感染的早产儿诊断价值。方法:选取93例入住惠州市中心人民医院新生儿科的PROM早产儿。根据是否发生细菌感染(生后72 h内),分为感染组(45例)和非感染组(48例),于出生后24 h内取血,测定血清LBP、PCT和IL-6的水平,通过联合绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC)。LBP、PCT和IL-6中两组的组合指标与每个指标比较,评估联合指标在预测PROM早产儿早期细菌感染的诊断价值。结果:LBP和PCT、LBP和IL-6、PCT和IL-6在诊断PROM早产儿早期细菌感染诊断中的AUC分别为0.976、0.977和0.728。LBP/PCT与PCT、LBP/IL-6与IL-6、PCT/IL-6与PCT、PCT/IL-6与IL-6在AUC值上有显著性差异。LBP/PCT与LBP、LBP/IL-6与LBP的AUC值比较差异无统计学意义。结论:联合检测LBP、PCT、IL-6可提高PROM早产儿细菌感染的早期诊断价值。
Abstract:
Objective: To evaluate the diagnostic value of lipopolysaccharide binding protein (LBP) combined with procalcitonin (PCT) and interleukin -6(IL-6) in bacterial infection in preterm infants with premature rupture of membranes(PROM). Methods: 93 cases preterm infants of PROM in Huizhou Central People’s Hospital were collected. Premature infants were divided into infection group(45 cases) and non-infection group(48 cases) according to the diagnostic criteria within 72 hours after birth. The serum levels of LBP, PCT and IL-6 were detected within 24 hours after birth. Receiver operator characteristic(ROC)curve was jointly drawn and area under the curve (AUC) was calculated. The combined indexes of LBP , PCT and IL-6 were compared with each index. The diagnostic value of combined indexes in early bacterial infection in preterm infants with PROM were evaluated. Results: Diagnosis of early bacterial infection in preterm infants with PROM by combined index showed that the AUC of ROC for LBP and PCT, LBP and IL-6, PCT and IL-6 were 0.976,0.977,0.728, respectively. The result of AUC was significant difference between LBP/PCT and PCT, LBP/IL-6 and IL-6, PCT/IL-6 and PCT, PCT/IL-6 and IL-6. The result of AUC was no significant difference between LBP/PCT and LBP, LBP/IL-6 and LBP. Conclusion: Combined detection of LBP, PCT and IL-6 can improve the early diagnostic value of early bacterial infection in premature infants with PROM.

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备注/Memo

备注/Memo:
作者简介 饶红萍(1981-),女,副主任医师,硕士,研究方向:新生儿学;
通信作者:李易娟,E-mail:liyijuansums@126.com。
更新日期/Last Update: 2020-06-02