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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年03期

页码:

305-308,312

栏目:

综述

出版日期:

2019-05-20

文章信息/Info

Title:

-

文章编号:

1006-8147(2019)03-0305-05

作者:

张丽梅1; 贾莉莉2 综 述; 喻文立2 审 校

（1.天津医科大学第一中心临床学院，天津300192；2.天津市第一中心医院麻醉科，天津300192）

Author(s):

-

关键词:

外泌体; 病毒性肝炎; 肝硬化; 肝癌

Keywords:

-

分类号:

R575

DOI:

-

文献标志码:

A

摘要:

外泌体是由细胞分泌的直径30~100 nm圆形或椭圆形的膜性囊泡，携带蛋白质、脂质和RNA等多种功能成分，在细胞间信息传递中承担着重要作用。近年来研究发现外泌体可通过血液循环转运至邻近或远处特定器官，参与体内重要的生理病理过程，在细胞通讯、细胞迁移、血管新生、免疫反应和肿瘤细胞生长等方面发挥着重要作用，影响疾病的发生发展。本文主要对外泌体在肝脏疾病尤其是病毒性肝炎、肝硬化和肝癌中的作用进行简要综述。外泌体在肝脏疾病中的作用机制亟待进一步研究，如何将外泌体应用于临床肝脏疾病的诊断治疗将成为未来研究的重点。

Abstract:

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备注/Memo

备注/Memo:

基金项目 天津市卫生行业重点攻关项目（16KG101）；天津市自然科学基金项目（18JCYBJC27500）
作者简介 张丽梅(1994-)，女，硕士在读，研究方向：麻醉学；通信作者：喻文立，E-mail:yzxyuwenli@163.com。

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更新日期/Last Update: 2019-07-03