|本期目录/Table of Contents|

[1]崔 鹏,杨建立.奥卡西平治疗的精神分裂症兴奋激越患者的效果及对血清Hcy的影响[J].天津医科大学学报,2019,25(01):66-69.
　CUI Peng,YANG Jian-Li.Effect of oxcarbazepine on patients with schizophrenia and excitement and its effect on serum Hcy[J].Journal of Tianjin Medical University,2019,25(01):66-69.
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奥卡西平治疗的精神分裂症兴奋激越患者的效果及对血清Hcy的影响(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年01期
页码:
66-69
栏目:
临床医学
出版日期:
2019-01-20

文章信息/Info

Title:
Effect of oxcarbazepine on patients with schizophrenia and excitement and its effect on serum Hcy
文章编号:
1006-8147(2019)01-0066-04
作者:
崔 鹏1; 2; 杨建立3
（1.天津医科大学研究生院，天津 300070；2天津市安定医院精神科，天津 300222；3.天津医科大学总医院临床心理科，天津 300052）
Author(s):
CUI Peng1; 2; YANG Jian-Li3
（1. Graduate School, Tianjin Medical University, Tianjin 300070, China；2.Department of Psychiatry,Tianjin Anding Hospital,Tianjin 300222,China；3.Department of Clinical Psychology,General Hospital, Tianjin Medical University, Tianjin 300052，China）
关键词:
奥卡西平; 精神分裂症; 兴奋激越; 同型半胱氨酸
Keywords:
oxcarbazepine; schizophrenia; agitation; homocysteine
分类号:
R749.3
DOI:
-
文献标志码:
A
摘要:
目的：探讨奥卡西平治疗精神分裂症兴奋激越患者的临床效果及对血清同型半胱氨酸（Hcy）水平的影响。方法：选取我院（2015年1月-2017年2月）治疗的100例精神分裂症患者，采用随机数字表法分为联合组和对照组各50例，联合组采用奥氮平联合奥卡西平治疗，对照组仅给予奥氮平治疗，对比两组治疗2周、4周后的阴性与阳性症状量表（PANSS）评分、外显攻击行为量表（MOAS）评分、血清Hcy水平及各类不良反应。结果：治疗前，联合组和对照组患者的阳性症状因子、阴性症状因子、一般精神病理学因子及PANSS总分差异无统计学意义（P >0.05）；治疗2周、4周后，两组患者的阳性症状因子、阴性症状因子、一般精神病理学因子及PANSS总分较治疗前均显著的降低（P <0.05），联合组低于对照组患者（P <0.05）；治疗前，联合组和对照组患者的MOAS评分、血清Hcy差异无统计学意义（P >0.05）；治疗4周后，两组患者的MOAS评分、血清Hcy较治疗前均显著的降低（P <0.05），联合组低于对照组患者（P <0.05）；治疗过程中，联合组的不良反应发生率（28.00%）高于对照组的14.00%，但差异无统计学意义（P >0.05）。结论：奥卡西平治疗精神分裂症兴奋激越患者有助于尽快控制患者的临床症状，达到更好的治疗效果。
Abstract:
Objective: To explore the clinical effects of oxcarbazepine on patients with schizophrenia and excitement, and the effect on serum Hcy levels. Methods：A hundred patients with schizophrenia treated in our hospital (January 2015-February 2017) were selected according to the random number table method, and 50 cases were divided into the combined group and the control group. The combination group was treated with olanzapine and oxcarbazepine. The control group was only treated with olanzapine. PANSS score, MOAS score, serum Hcy level and various adverse reactions were compared between the two groups after 2 weeks and 4 weeks. Results：There were no significant differences in positive symptom factors, negative symptom factors, general psychopathological factors and PANSS scores between the combined group and the control group before treatment (P>0.05). Two weeks and 4 weeks after treatment, the positive symptom factors, negative symptom factors, general psychopathological factors and PANSS total scores of the two groups were significantly lower than those before treatment (P<0.05), and the factors for combined group were lower than those of the control group (P<0.05); Before treatment, there was no significant difference in MOAS score and serum Hcy between the combined group and the control group (P>0.05). After 4 weeks of treatment, the MOAS score and serum Hcy of the two groups were significantly lower than those before treatment (P<0.05), and those for the combined group was lower than the control group (P<0.05). During the treatment, the incidence of adverse reactions in the combined group was 28.00% higher than that in the control group, but the difference was not statistically significant(P>0.05). Conclusion：Oxcarbazepine in patients with schizophrenia excitatory agitation may help to control the patients’ clinical symptoms as soon as possible with better therapeutic results.

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备注/Memo

备注/Memo:

作者简介 崔鹏（1979-），男，副主任医师，硕士在读，研究方向：精神病与精神卫生学；通信作者：杨建立，E-mail：2173961183@qq.com。
更新日期/Last Update: 2019-03-01