|本期目录/Table of Contents|

[1]马晓雷,孙焕君,和西波,等.中国精神分裂症患者认知能损害性别差异的P300证据[J].天津医科大学学报,2019,25(02):167-170.
 MA Xiao-lei,SUN Huan-jun,HE Xi-bo,et al.P300 evidence for the gender difference in cognitive impairment in Chinese patients with schizophrenia[J].Journal of Tianjin Medical University,2019,25(02):167-170.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年02期
页码:
167-170
栏目:
精神医学
出版日期:
2019-03-20

文章信息/Info

Title:
P300 evidence for the gender difference in cognitive impairment in Chinese patients with schizophrenia
文章编号:
1006-8147(2019)02-0167-04
作者:
马晓雷1孙焕君2和西波2李美娟3李 洁3
(1.天津医科大学研究生院,天津300070;2.天津市安宁医院精神科,天津300300;3.天津市安定医院精神科,天津300222)
Author(s):
MA Xiao-lei1 SUN Huan-jun2 HE Xi-bo2 LI Mei-juan3 LI Jie3
(1.Graduate School, Tianjin Medical University , Tianjin 300070,China; 2. Department of Psychiatric,Tianjin Anning Hospital, Tianjin 300300,China;3. Department of Psychiatric,Tianjin Anding Hospital, Tianjin 300222,China)
关键词:
精神分裂症P300性别Meta分析
Keywords:
schizophreniaP300gendermeta-analysis
分类号:
R749.3
DOI:
-
文献标志码:
A
摘要:
目的:用Meta分析系统评价中国精神分裂症(分裂症)患者的认知电位P300的性别差异。方法:计算机检索中英文数据库,收集对比男性和女性分裂症患者P300潜伏期和波幅的研究文献,按照匹配原则评价纳入研究的质量。采用Meta分析计算男性和女性分裂症患者P300潜伏期和波幅性别差异的标化加权均数差(SMD)。结果:合计9项研究(300例男性和269例女性患者)纳入Meta分析,其中5项为高质量研究。男性患者的P300潜伏期长于女性患者,但P300波幅短于女性患者,其SMD分别为0.28(95%CI: 0.11, 0.44)和-0.56(95%CI: -0.89, -0.23),差异均具有统计学意义(P =0.003和P =0.001)。结论:中国分裂症患者P300潜伏期和波幅存在显著的性别差异。
Abstract:
Objective: To systematically assess the gender difference in the P300 cognitive event-related potential of Chinese patients with schizophrenia. Methods: We searched Chinese and English databases and collected studies to compare P300 latency and amplitude between Chinese male and female schizophrenia patients. Quality of included studies was assessed according to the matching principal. The standardized weighted mean differences (SMDs) of P300 latency and amplitude between male and female patients were calculated by Meta-analysis. Results: Nine studies (300 males and 269 females) were included, 5 of which were judged as having high quality. Male patients had significantly longer P300 latency and lower P300 amplitude than female patients(P =0.003 and P =0.001), and their SMDs were 0.28 (95% CI: 0.11, 0.44) and -0.56(95% CI: -0.89, -0.23), respectively. Conclusion: There are significant gender differences in the P300 latency and amplitude of Chinese patients with schizophrenia.

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备注/Memo

备注/Memo:
作者简介 马晓雷(1984-),男,主治医师,硕士在读,研究方向:精神疾病电生理学;通信作者:李洁,E-mail: tjlijie3827@163.com。
更新日期/Last Update: 2019-04-25