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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年01期

页码:

63-65，69

栏目:

临床医学

出版日期:

2019-01-20

文章信息/Info

Title:

Study on the difference of miR-181b expression in patients with schizophrenia before and after fluoxetine treatment

文章编号:

1006-8147(2019)01-0063-03

作者:

杜 彬¹; 2；杨建立³

（1.天津医科大学研究生院，天津 300070，2.天津市安定医院精神科，天津 300222，3.天津医科大学总医院临床心理科，天津300052）

Author(s):

DU Bin¹; 2；YANG Jian-Li³

（1.Graduate School,Tianjin Medical University,Tianjin 300070 China;2.Department of Psychiatry,Tianjin Anding Hospital,Tianjin 300222,China;3.Department of Clinical Psychology,General Hospital,Tianjin Medical University,Tianjin 300052,China）

关键词:

氟西汀; 精神分裂症; miR-181b

Keywords:

fluoxetine;  schizophrenia;  miR-181b

分类号:

R749.3

DOI:

-

文献标志码:

A

摘要:

目的：探讨氟西汀治疗精神分裂症的疗效及对患者外周血miR-181b表达的影响。方法：选取我院2016年5月-2017年5月收治的精神分裂症患者160例，按照随机数字表法均分为观察组和对照组，每组80例。对照组患者给予抗精神病药物治疗，观察组患者在此基础上加用氟西汀治疗。治疗８周后检测两组患者的miR-181b表达水平，观察两组患者生活质量评分变化并记录不良反应的发生情况。结果：治疗前两组患者miR-181b表达水平比较，差异无统计学意义（P>0.05）；同组治疗前后相比,两组患者miR-181b表达水平均显著降低（P<0.05），观察组明显低于对照组,两组之间具有显著性差异（P<0.05）。治疗前两组患者的生活质量评分比较，差异无统计学意义（P>0.05）；治疗后两组患者的生活质量评分均高于治疗前，且观察组明显高于对照组，差异均有统计学意义（P<0.05）。观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）。结论：氟西汀可通过调控患者外周血miR-181b的表达从而发挥其抗精神病的作用，有利于提高患者的生活质量。

Abstract:

Objective: To explore the effect of fluoxetine in the treatment of schizophrenia and its effect on the expression of miR-181b in patients. Methods: One hundred and sixty cases of schizophrenia patients were randomly divided into observation group and control group in our hospital from May 2016 to May 2017, and each group had 80 cases. The patients in the control group were treated with antipsychotic drugs, and the patients in the observation group were treated with fluoxetine on this basis. After 8 weeks of treatment, the levels of miR-181b expression in the two groups were detected, and the quality of life scores of the two groups was observed and the incidence of adverse reactions was recorded. Results: There was no significant difference in the levels of miR-181b expression between the two groups before treatment（P>0.05）. Comparison in the same group before and after treatment showed the miR-181b expression levels of the two groups were significantly lower, and the observation group was significantly lower than that in the control group. Difference was statistically significant in the two groups（P< 0.05）. Before treatment, there was no significant difference in the life quality between the two groups（P>0.05）. After treatment, the life quality scores of the two groups were higher than those before treatment, and the observation group was significantly higher than that of the control group. The difference was statistically significant（P<0.05）. The incidence of adverse reactions in the observation group was not significantly different from that in the control group（P>0.05）. Conclusion: Fluoxetine can improve life quality of the patients and exert its antipsychotic effect by regulating the expression of miR-181b in patients.

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备注/Memo

备注/Memo:

作者简介 杜彬(1984-)，男，硕士在读，主治医师，研究方向：精神病与精神卫生学；通信作者：杨建立，E-mail: 2173961183@qq.com。

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更新日期/Last Update: 2019-03-01