|本期目录/Table of Contents|

[1]王 雪,唐生安,段宏泉.膜荚黄芪中皂苷类化学成分研究[J].天津医科大学学报,2017,23(06):516-518.
　WANG Xue,TANG Sheng-an,DUAN Hong-quan.Studies on Astragalosides from Astragalus membranceus(Fisch) Bge[J].Journal of Tianjin Medical University,2017,23(06):516-518.
点击复制

膜荚黄芪中皂苷类化学成分研究(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23卷
期数:
2017年06期
页码:
516-518
栏目:
基础医学
出版日期:
2017-11-20

文章信息/Info

Title:
Studies on Astragalosides from Astragalus membranceus(Fisch) Bge
文章编号:
1006-8147(2017)06-0516-03
作者:
王 雪1; 唐生安1; 段宏泉1; 2
(天津医科大学1. 药学院，天津市临床药物关键技术重点实验室；2.基础医学研究中心，天津 300070)

Author(s):
WANG Xue1; TANG Sheng-an 1;  DUAN Hong-quan1; 2
(1.School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics)，Tianjin Medical University，Tianjin 300070, China; 2. Research Center of Basic Medical Sciences,Tianjin Medical University, Tianjin 300070, China)
关键词:
膜荚黄芪; 化学成分; 色谱分离; 皂苷类; Cyclocanthoside A
Keywords:
Astragalus membranceus(Fisch) Bge;  chemical constituents;  chromatographic separation;  Astragalosides;  Cyclocanthoside A

分类号:
R914
DOI:
-
文献标志码:
A
摘要:
目的 :研究膜荚黄芪中皂苷类化学成分。方法: 采用硅胶柱色谱和HPLC制备色谱方法分离纯化得到单体化合物，采用有机波谱方法鉴定化合物结构。结果: 从膜荚黄芪乙醇提取物中分离得到7个皂苷类化合物，分别为Cyclocanthoside A (1)，IsoastragalosideⅣ(2)，Cyclocanthoside E (3)，AstragalosideⅦ(4)，AstragalosideⅢ(5)，AstragalosideⅥ(6)，黄芪甲苷Ⅳ(7)。结论: 化合物1为首次从该植物中分离得到。
Abstract:
Objective: To studyastragalosides from astragalusmembranceus(Fisch) Bge.Methods: Chemical constituents were isolated and purified by repeated column chromatography (silica geland preparative HPLC). Their structures were elucidated on the basis of spectral data analysis.Results: Seven compounds (1~7) were isolated and their structures were identified by comparison of their spectral data with literature values as follows: Cyclocanthoside A (1), IsoastragalosideⅣ(2), Cyclocanthoside E (3),AstragalosideⅦ (4), AstragalosideⅢ (5), AstragalosideⅥ(6), AstragalosideⅣ (7).Conclusion: Compounds 1has been isolated from this plant for the first time.

参考文献/References:

[1]中华人民共和国卫生部药典委员会.中华人民共和国药典一部[S].2010版.一部.北京:中国医药科技出版社.2010:283-285

[2]单俊杰,王顺春,刘涤, 等.黄芪多糖的化学和药理研究进展[J].上海中医大学学报, 2000,14(3):61

[3]温海梅.黄芪的化学成分研究进展[J].中成药, 2006,28(6):879

[4]米红, 李燕舞, 王晓燕, 等.黄芪总苷对脾虚大鼠胃黏膜保护机制探讨[J].中药药理与临床, 2012,28(5):61

[5]Mamedova R P.,.Isaev M I.Triterpenoids from astragalus plants[J].

Chem Nat Compounds, 2004,40(4):317

[6]Isaev M I, Imomnazarov B A, Fadeev.Y .M., et al.Triterpeneglycosides ofAstragalus and their genins XL II . Cycloartanesof Astragalustragacantha[J]. .Chem.Nat.Compd., 1992,28: 315

[7] Zhou Y,Hirotani M, Rui H, et al. Two triglycosidictriterpeneastragalosides from hairy root cultures of Astragalusmembranaceus.[J]..Phytochemistry, 1995,38(6): 1407

[8]Hirotani M., Zhou Y, Lui H K. Astragalosides from hairyroot cultures of Astragalusmembranaceus[J]. Phytochem, 1994,36(3):665

[9]Kitagawa I,. Wang H K, SaitoM. , et al.Chemical constituents of Astragali radix, the root of Astragalusmembranaceusbunge. Astragalosides III, V, and VI[J].ChemPharm Bill , 1983, 31(2):709

[10]杨彦春, 李艳花, 辛延乐, 等.黄芪皂苷对多发性硬化作用的研究进展[J].山西大同大学学报, 2016,32(1):48

相似文献/References:

[1]许娇娇,靳德军,王 佳,等.中国南海海绵Haliclona sp.中化学成分的研究[J].天津医科大学学报,2015,21(05):385.
　XU Jiao-jiao,JIN De-jun,WANG Jia,et al.Studies on chemical constituents from the South China Sea sponge Haliclona sp.[J].Journal of Tianjin Medical University,2015,21(06):385.
[2]赵 娜,赵国华,王仁久,等.大株红景天化学成分的研究[J].天津医科大学学报,2016,22(02):119.
　ZHAO Na,ZHAO Guo-hua,WANG Ren-jiu,et al.Studies on chemical constituents fromＲhodiola wallichiana [J].Journal of Tianjin Medical University,2016,22(06):119.
[3]杨 柳,王 雪,王 佳,等.白胡椒化学成分研究[J].天津医科大学学报,2016,22(04):300.
　YANG Liu,WANG Xue,WANG Jia,et al.Research?on constituents?of Pipernigrus L.[J].Journal of Tianjin Medical University,2016,22(06):300.
[4]高晓宇,丁茹 综述,王道平,等.钩藤化学成分及药理作用研究进展[J].天津医科大学学报,2017,23(04):380.
[5]杜怡波,樊慧蓉综述,阎昭审校.阿胶的化学成分及药理作用研究进展[J].天津医科大学学报,2018,24(03):267.
[6]王 雪,唐生安,段宏泉.膜荚黄芪中黄酮类化学成分研究[J].天津医科大学学报,2016,22(05):409.
　WANG Xue,TANG Sheng-an,DUAN Hong-quan.Studies on flavonoids and related constituents from Astragalus membranceus(Fisch) Bge[J].Journal of Tianjin Medical University,2016,22(06):409.

备注/Memo

备注/Memo:
作者简介 王雪(1986-)，女，实验师，硕士，研究方向：天然药物化学；通信作者：段宏泉，E-mail:duanhq@tmu.edu.cn。
更新日期/Last Update: 2017-11-14