|本期目录/Table of Contents|

[1]王 雪,唐生安,段宏泉.膜荚黄芪中黄酮类化学成分研究[J].天津医科大学学报,2016,22(05):409-411.
　WANG Xue,TANG Sheng-an,DUAN Hong-quan.Studies on flavonoids and related constituents from Astragalus membranceus(Fisch) Bge[J].Journal of Tianjin Medical University,2016,22(05):409-411.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年05期
页码:
409-411
栏目:
基础医学
出版日期:
2016-09-20

文章信息/Info

Title:
Studies on flavonoids and related constituents from Astragalus membranceus(Fisch) Bge
文章编号:
1006-8147（2016）05-0409-03
作者:
?王 雪1; 唐生安1; 段宏泉1; 2
?(天津医科大学1. 药学院，天津市临床药物关键技术重点实验室；2. 基础医学研究中心，天津 300070)
Author(s):
WANG Xue1;  TANG Sheng-an 1;  DUAN Hong-quan1; 2
(Tianjin Medical University 1.School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of ClinicalTherapeutics and Diagnostics (Theranostics); 2. Research Center of Basic Medical Sciences,Tianjin Medical University, Tianjin 300070, China)
关键词:
膜荚黄芪; 化学成分; 色谱分离; 黄酮类; 2’; 7-二羟基-3’; 4’-二甲氧基异黄烷-2’-O-β-D-吡喃葡萄糖苷
Keywords:
Astragalus membranceus(Fisch) Bge;  chemical constituents;  Chromatographic separation;  flavonoids;  sphaerophyside SB

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分类号:
R91
DOI:
-
文献标志码:
A
摘要:
目的 : 研究膜荚黄芪中黄酮类化学成分。方法: 采用硅胶柱色谱和HPLC制备色谱方法分离纯化得到单体化合物，采用有机波谱方法鉴定化合物结构。结果: 从膜荚黄芪乙醇提取物中分离得到8个黄酮类化合物，分别为2’,7-二羟基-3’,4’-二甲氧基异黄烷-2’-O-β-D-吡喃葡萄糖苷(1)，3’,4’-二甲基异黄烷(2)，芒柄花素(3)，芒柄花素-7-O-β-D-葡萄糖苷(4)，毛蕊异黄酮(5)，(6aR,11aR)3-羟基-9,10-二甲氧基紫檀烷(6)，(6aR,11aR)9,10-二甲氧基紫檀烷-3-O-β-D-葡萄糖苷(7)，7,2’-二羟基-3’,4’-二甲氧基异黄烷-7-O-β-D-葡萄糖苷(8)。结论: 化合物1为首次从该属植物中分离得到。
Abstract:
Objective: To study flavonoids and relatedconstituents from Astragalus membranceus(Fisch) Bge. Methods: Chemical constituents were isolated and purified by repeated column chromatography (silica geland preparative HPLC). Their structures were elucidated by spectral data analysis. Results: Eight compounds (1-8) were isolated and their structures were identified by comparing their spectral data with literature values as follows: sphaerophyside SB(1), isomucronulatol(2), formononetin(3),formononetin-7-O-β-D-glycoside(4), calycosin(5), methylnissolin(6), (6aR,11aR) 9,10-dimethoxypterocarpan-3-O-β-D- glycoside(7), 7,2’-dihydroxy-3’,4’-dimethoxy-isoflavane-7-O-β-D-glycoside(8). Conclusion: Compounds 1 could be isolated from this plant for the first time.

参考文献/References:

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备注/Memo

备注/Memo:
?作者简介 王雪(1986-)，女，实验师，硕士，研究方向：天然药物化学；通信作者：段宏泉，E-mail:duanhq@tmu.edu.cn。
更新日期/Last Update: 2016-09-19