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[1]罗 西,姜 溪,只德广,等.复方三维右旋泛酸钙糖浆对幼龄大鼠厌食症的治疗作用及机制研究[J].天津医科大学学报,2017,23(06):502-505.
　LUO Xi JIANG Xi,ZHI De-guang,CHEN Fu-rong,et al.Therapeutic effects and mechanisms of compound trivitamin and calcium pantothenate syrup on the young anorexia rats[J].Journal of Tianjin Medical University,2017,23(06):502-505.
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复方三维右旋泛酸钙糖浆对幼龄大鼠厌食症的治疗作用及机制研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23卷
期数:
2017年06期
页码:
502-505
栏目:
基础医学
出版日期:
2017-11-20

文章信息/Info

Title:
Therapeutic effects and mechanisms of compound trivitamin and calcium pantothenate syrup on the young anorexia rats
文章编号:
1006-8147(2017)06-0502-04
作者:
罗 西1; 2; 姜 溪3; 只德广3 ; 陈芙蓉3 ; 王银松1
(1.天津医科大学药学院,天津300070 ;2.天津市胸科医院药剂科,天津 300051; 3.天津药物研究院新药评价有限公司,天津 300301)
Author(s):
LUO Xi1; 2 JIANG Xi 3 ; ZHI De-guang3;  CHEN Fu-rong3;  WANG Yin-song1

(1. School of Pharmacy, Tianjin Medical University, Tianjin 300070，China;2. Department of Pharmacy，Tianjin Chest Hospital, Tianjin 300051 ,China; 3. TIPR Drug Assessment Co.Ltd,Tianjin 300301, China)

关键词:
幼龄大鼠; 厌食症; 消化吸收; 胃肠激素
Keywords:
young rats;  anorexia;  digestive absorption;  gastrointestinal hormone
分类号:
R9
DOI:
-
文献标志码:
A
摘要:
目的 ：采用幼年大鼠厌食症模型，评价复方三维右旋泛酸钙糖浆的治疗作用，探讨作用机制。方法 ：构建幼龄大鼠厌食症模型，按剂量分组，给药2周，检测进食量、体质量、血清琥珀酸脱氢酶（SDH）、苹果酸脱氢酶（MDH）、丙酮酸激酶（PK）、生长抑素（SS）、胃泌素（Gastrin）及饥饿素（ghrelin），然后进行胃肠运动和胃消化功能试验。结果： 灌胃给药后，幼龄厌食症大鼠体质量能够显著增加，血清MDH与SDH活力升高，Gastrin含量增加，ghrelin含量降低，胃液分泌、总酸及游离酸的排出量增加，胃蛋白酶活力升高。结论： 复方三维右旋泛酸钙糖浆对幼龄大鼠厌食症有明显的治疗作用，主要机制是增加食欲，促进食物的消化吸收。
Abstract:
Objective: To evaluate the therapeutic effects of Compound Trivitamin and Calcium Pantothenate Syrup and explore its mechanisms by using the young anorexia rat model. Methods: The rat model of anorexia was established using the mixed feed. The anorexia rats were divided into different groups and then continuously administrated at different drug doses for 2 weeks. During the treatment period, the food intakes, body weights, serum levels of SDH, MDH, PK, SS, Gastrin, and ghrelin of these rats were detected to evaluate the drug effects. Furthermore, the gastrointestinal movement and stomach digestive function in these rats were also assessed to explore the functional mechanisms of the drug. Results: After intragastric administration, the body weights of these anorexia rats significantly increased, the activities of MDH and SDH in serum were enhanced； the Gastrin content increased, but the ghrelin content decreased. In addition, the gastric secretion was promoted, the total acid and free acid excretion increased, and the pepsin activity was elevated. Conclusion: Compound Trivitamin and Calcium Pantothenate Syrup has marked therapeutic efficacy on anorexia in young rats, and the increase of appetite, the enhancements of food digestion and absorption may be its main functional mechanisms.

参考文献/References:

[1].Hanachi-Guidoum M. Treating the somatic complications of?anorexia[J]. Soins Psychiatr,2016, 37(307): 34
[2].禹玉洪, 张国伟, 杨晓宁等. 丁桂儿脐贴联合用药对幼龄大鼠厌食模型的影响[J]. 中药药理与临床 2013, 29(6):134
[3].石艳红. 运脾法及其组方治疗小儿厌食征的机制研究[D]. 广州中医药大学2008.
[4].彭苍骄, 郑优敏, 管敏昌. 复方三维右旋泛酸钙糖浆治疗儿童厌食症[J]. 海峡药学2012, 24(1): 171
[5].李丽花硫胺素、核黄素和烟酰胺对肥胖大鼠能量代谢和空间学习记忆能力的影响[D]. 青岛大学2014.
[6].McCune A M, Lundgren J D. Bright light therapy for the treatment of night eating syndrome: a pilot study. Psychiatry Research, 2015, 229 (1/2): 577
[7].吴丽萍, 王艳丽. 小儿增食灵合剂对小儿厌食症动物模型胃蛋白酶活性和胃酸分泌量的影响[J]. 中医儿科杂志, 2007, 3(3): 26
[8].孔晓伟, 李清. 保和丸对小鼠胃排空和小肠推进的影响[J]. 河北医科大学学报2005, 26(6): 700
[9].吴艳梅, 王钢. 中医药治疗小儿厌食症的研究进展[J]. 贵阳中医学院学报2013, 35(6): 295
[10].赵琼, 徐世军, 霍敏俐. 加减益胃汤治疗小儿脾胃阴虚厌食症的实验研究[J]. 成都中医药大学学报2005, 28(3): 15
[11].王亚萍, 李江全. 小儿厌食症的中西医发病机制研究进展[J]. 浙江中西医结合杂志2013, 23(4): 335
[12].张海燕, 鲁格兰, 朱冬梅等. 厌食和睡眠障碍儿童血清胃动素、生长抑素、Ghrelin水平变化及临床意义[J]. 临床儿科杂志2010, 28(7): 659
[13].陈松松. 厌食儿童血清瘦素、肿瘤坏死因子-α、血浆Ghrelin水平与免疫功能的变化研究[D]. 中南大学2010.
[14].Su J, Geng J, Bao J, et al. Two?ghrelin?receptor?agonists?for?adults?with?malnutrition: a? systematic?review?and?meta-analysis[J]. Nutr J, 2016, 15(1): 97
[15].Navarro-Guillén C,?Yúfera M,?Engrola S. Ghrelin?in senegalese sole (solea senegalensis) postlarvae: paracrine effects on food intake[J]. Comp Biochem Physiol A Mol Integr Physiol,?2017, 204: 85
[16].Takagi K, Legrand R,?Asakawa A, et al. Anti-ghrelin?immunoglobulins modulate?ghrelinstability and its orexigenic effect in obese mice and?humans[J]. Nat Commun,2013, 4: 2685
[17].王世香. 复方壮阳中药对大鼠股四头肌能量代谢的影响[D]. 曲阜师范大学2007.
[18].孔喜良. 黄芪多糖对大鼠肌组织能量代谢的影响[J]. 中国全科医学2009, 12(10B): 1907

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备注/Memo

备注/Memo:

作者简介 罗西(1988-),男，药师，学士，研究方向：临床药学；

通信作者：王银松， E-mail: wangyinsong@tmu.edu.cn。



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更新日期/Last Update: 2017-11-14