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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年05期

页码:

404-407

栏目:

临床医学

出版日期:

2015-09-20

文章信息/Info

Title:

¹⁸F-FDG PET/CT in detecting synchronous primary neoplasms for initial stage of esophageal cancer

文章编号:

1006-8147（2015）05-0404-04

作者:

?周 雯¹ ; 朱 湘² ; 王 健² ; 徐文贵²

?

Author(s):

ZHOU Wen ¹;  ZHU Xiang²;  WANG Jian²;  XU Wen-gui²

(1. School of Pharmacy, Tianjin Medical University,? Tianjin 300070,China；2. Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China)

关键词:

食管癌; PET/CT; 重复癌; 分期

Keywords:

esophageal cancer' target="_blank" rel="external">">esophageal cancer;  PET/CT;  synchronous neoplasms;  staging

分类号:

R735.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨¹⁸F-FDG PET/CT显像在食管癌分期时发现同时性重复癌的价值。方法：回顾性研究171例病理证实的食管癌患者应用¹⁸F-FDG PET/CT显像进行分期的影像资料，位于食管癌常见转移部位以外的¹⁸F-FDG代谢增高灶，或代谢方式和程度与原发灶明显不一致者，首先考虑同时性重复癌，并根据病灶部位经手术、内镜或穿刺活检等获得病理学结果的方法。结果：171例病理证实的食管癌患者中，病理诊断重复癌35例，其中¹⁸F-FDG PET/CT和病理共同诊断阳性的重复癌33例，部位依次为下咽癌14例、肺癌8例、胃癌6例、舌癌2例、乙状结肠癌1例、口咽癌1例，还有1例同时发现乙状结肠癌及胃癌。¹⁸F-FDG PET/CT诊断重复癌的灵敏度为94.3%，特异性为94.2%，准确性为94.2%。结论：应用¹⁸F-FDG PET/CT显像进行食管癌分期时可以有效发现同时性重复癌，显像阳性患者术前必须进一步明确病变的性质，将会直接影响治疗计划和预后。

Abstract:

Objective: To determine the additional clinical value of ¹⁸F-FDG PET/CT in detecting synchronous neoplasms in initial stage of esophageal cancer. Methods: 171 patients with biopsy-proven malignancy of the esophagus underwent ¹⁸F-FDG PET for initial stage. Synchronous malignancies were defined by abnormal ¹⁸FDG uptake on

¹⁸FDG-PET which was unlikely due to distant metastases from the primary esophageal lesion depending on intensity and pattern，and confirmed by pathology. Results: Thirty-five synchronous primary neoplasms were identified in 171patients and 33 neoplasms were PET/CT-positive. Among them. 14 neoplasms were discovered in the laryngeal pharynx, 8 in the lung, 6 in the stomach, 2 in the tongue, 1 in the sigmoid colon, 1 in the oral pharynx and 1 in both stomach and sigmoid colon. The sensitivity, specificity and accuracy of ¹⁸F-FDG PET/CT were 94.3%, 94.2% and 94.2% ,respectively. Conclusion: ¹⁸F-FDG PET can detect unexpected synchronous primary neoplasms in patients with esophageal cancer. Sites of pathologic ¹⁸F-FDG uptake should be confirmed by additional investigations before treatment, because synchronous neoplasms may cause metastases and influence the therapeutic plan.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介? 周雯（1981-），女，博士，研究方向：药学及核医学；

通信作者：徐文贵，E-mail:wwbzzl@sina.com.。

常用功能

更新日期/Last Update: 2015-09-22