|本期目录/Table of Contents|

[1]贾朝阳,徐文贵,朱 磊,等.18F-FDG PET/CT在结直肠癌术后预后中的应用[J].天津医科大学学报,2019,25(04):342-345355.
 JIA Zhao-yang,XU Wen-gui,ZHU Lei,et al.The application of 18F-FDG PET/CT in the prognosis of postoperative colorectal cancer[J].Journal of Tianjin Medical University,2019,25(04):342-345355.
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18F-FDG PET/CT在结直肠癌术后预后中的应用(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25
期数:
2019年04期
页码:
342-345355
栏目:
临床医学
出版日期:
2019-07-20

文章信息/Info

Title:
The application of 18F-FDG PET/CT in the prognosis of postoperative colorectal cancer
文章编号:
1006-8147(2019)04-0342-04
作者:
贾朝阳徐文贵朱 磊朱 湘张利卜
(天津医科大学肿瘤医院分子影像与核医学诊疗科,国家肿瘤临床医学研究中心;天津市“肿瘤防治”重点实验室;天津市恶性肿瘤临床医学研究中心,天津 300060)
Author(s):
JIA Zhao-yang XU Wen-gui ZHU Lei ZHU Xiang ZHANG Li-bo
(Department of Molecular Imaging and Nuclear Medicine, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300060, China)
关键词:
PET/CT代谢参数结直肠癌预后
Keywords:
PET/CTmetabolic parameterscolorectal cancerprognosis
分类号:
R735.34
DOI:
-
文献标志码:
A
摘要:
目的:探讨18F-脱氧葡萄糖(FDG)PET/CT在结直肠癌术后预后中的应用价值。方法:回顾性分析行PET/CT检查后进行手术切除且资料完整的73例结直肠癌患者,研究PET/CT代谢参数与其术后预后的关系。结果:结直肠癌区域淋巴结转移阳性者原发灶MTV明显高于阴性者,其预测淋巴结转移的最佳截断值为7.39。SUVmax、SUVmean、SUVpeak、MTV及TLG预测预后的最佳截断值分别为14.80、8.62、13.62、11.55及219.27。Cox单因素回归分析显示肿瘤的长径、N分期、M分期、MTV及TLG与预后有关,多因素分析显示M分期及MTV是预后的独立危险因素。Kaplan-Meier生存分析表明MTV≤11.55、TLG≤219.27的患者无进展生存期明显延长。结论:PET/CT在结直肠癌术后预后中具有应用价值,MTV、TLG能在一定程度上反映患者术后的预后情况。
Abstract:
Objective: To investigate the value of 18F-FDG PET/CT in the prognosis of postoperative colorectal cancer. Methods: A retrospective analysis was established by enrolling 73 colorectal cancer patients who underwent surgery after PET/CT examination.They all had complete data. The relationship between metabolic parameters and prognosis was studied. Results: MTV in colorectal cancer with lymph node metastasis were significantly higher than those with negative results,and the best cut-off value in predicting lymph node metastasis was 7.39.The best cut-off values for SUVmax, SUVmean, SUVpeak, MTV and TLG in predicting prognosis were respectively 14.80, 8.62, 13.62, 11.55 and 219.27. Univariate Cox regression analysis showed that tumor length, N stage, M stage, MTV and TLG were related to prognosis and multivariate analysis showed that M stage and MTV were independent risk factors. Kaplan-Meier survival analysis showed that progression free survival of patients with MTV ≤11.55 and TLG≤219.27 were significantly prolonged. Conclusion: PET/CT may have application value in the prognosis of colorectal cancer after surgery. MTV and TLG can reflect the prognosis of patients after operation.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介 贾朝阳(1993-),女,硕士在读,研究方向:影像医学与核医学;通信作者:徐文贵,E-mail:wenguixy@163.com。
更新日期/Last Update: 2019-08-28