«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年03期

页码:

220-222

栏目:

基础医学

出版日期:

2015-05-20

文章信息/Info

Title:

Effect of propofol combined with remifentanil on rabbit mesenteric microcirculation

文章编号:

1006-8147（2015）03-0220-03

作者:

张 杨¹; 于泳浩²

(1.天津医科大学第四中心临床学院麻醉科,天津 300140;2.天津医科大学总医院麻醉科,天津 300052)

Author(s):

ZHANG Yang¹;  YU Yong-hao²

(1. Department of Anesthesiology, The Fourth Central Clinical College, Tianjin Medical University,Tianjin 300140,China; 2. Department of Anesthesiology, General Hospital ,Tianjin Medical University, Tianjin 300052,China)

关键词:

丙泊酚; 瑞芬太尼; 兔; 微循环

Keywords:

propofol;  remifentanil;  rabbit;  microcirculation

分类号:

R614

DOI:

-

文献标志码:

A

摘要:

目的:探讨丙泊酚和瑞芬太尼联合应用对兔小肠系膜微循环的影响。方法：　将30只新西兰大白兔随机分为对照组（C组），丙泊酚组（P组），丙泊酚联合瑞芬太尼组（P+R组），每组10只。建立兔全麻模型后，C组持续泵入生理盐水，P组静脉持续泵入丙泊酚，P+R组静脉持续泵入瑞芬太尼和丙泊酚，分别记录3组给药前及给药0.5 h后新西兰大白兔的心率（HR）、平均动脉压（MAP），采用旁流暗视野技术测定新西兰大白兔小肠系膜微循环总血管密度（TVD）、灌注血管密度（PVD）、灌注血管比例（PPV）、微血管流动指数（MFI）。结果：与C组相比，给药后P组HR减慢， MAP 轻度下降，微循环血流明显增加，TVD、PVD、PPV、MFI均有所增加，差异均有统计学意义(P＜0.05)。与C组相比，给药后P+R组HR减慢，MAP显著下降，微循环血流明显减少，且差异均有统计学意义(P＜0.05)。结论：丙泊酚对兔小肠系膜循环有改善作用，丙泊酚和瑞芬太尼联合应用对兔小肠系膜微循环有抑制作用。

Abstract:

Objective: To investigate the effects of combination of propofol and remifentanil on mesenteric microcirculation in rabbits. Methods: Thirty New Zealand white rabbits were randomly divided into control group (group C), propofol group (P group) and propofol-remifentanil combination group (P+R group) with 10 rabbits in each group. Animal model was established given general anestyesia and 0.9% normal saline solution was infused in C group while propofol was infused in P group . Propofol combined with remifentanil administrated in P+R group. Multiple parameters of the rabbits in 3 groups were recorded before and half an hour after the administration of drugs, including heart rate (HR), mean arterial pressure (MAP),total vessel density (TVD) of mesenteric microcirculation by sidestream dark-field (SDF) technique, perfused vessel density (PVD), proportion of perfused vessels (PPV) and microvascular flow index (MFI). Results: Compared with group C, after administration of propofol (P group), HR in the group dropped, MAP decreased slightly, and blood flow of microcirculation increased significantly (p <0.05). In P+R group, HR and MAP decreased significantly with reduced blood flow in microcirculation, and the differences were statistically significant (P <0.05). No significant change of microcirculation parameters was found before and after normal saline solution administration in Group C. The microcirculation was enhanced after propofol infusion in the Pgroup (P <0.05). After the after administration of propofol and remifentanil, microcirculation for P + R group was significantly inhibited (P<0.05). Conclusion: Propofol improves mesenteric circulation while a combination of propofol and remifentanil inhibits mesenteric microcirculation in rabbit model.

参考文献/References:

[1]Pittman R N. Oxygen transport in the microcirculation and its regulation[J]. Microcirculation, 2013, 20(2): 117[2]Bezemer R, Bartels S A, Bakker J, et al. Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill - where do we stand[J]. Crit Care, 2012, 16(3): 224
[3]Hernandez G, Bruhn A, Castro R, et al. The holistic view on perfusion monitoring in septic shock[J]. Curr Opin Crit Care, 2012, 18(3): 280
[4]颜默磊，严静．多巴胺和去甲肾上腺素对脓毒性休克患者微循环的影响[J]．中国临床药理学与治疗学，2013，18（5）：565
[5]Koch M, De Backer D, Vincent J L, et al. Effects of propofol on human microcirculation[J]. Br J Anaesth, 2008, 101(4): 473[6]Jung C, Rodiger C, Lauten A, et al. Long-term therapy with propofol has no impact on microcirculation in medicalintensive care patients[J]. Med Klin (Munich), 2009, 104(5): 334
[7]Chen H I, Hsieh N K, Kao S J, et al. Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats[J]. Crit Care Med, 2008, 36(4): 1214
[8]Kemmochi M, Ichinohe T, Kaneko Y. Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits[J]. J Oral Maxillofac Surg, 2009, 67(6): 1245
[9]Degoute C S, Ray M J, Manchon M, et al. Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty[J]. Can J Anaesth, 2001, 48(1): 20

相似文献/References:

[1]许德芳,余剑波,牟 戎,等.不同全麻药物对体外循环患者氧化应激反应影响的比较[J].天津医科大学学报,2015,21(04):328.
　XU De-fang,YU Jian-bo,MU Rong,et al.Effect of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting[J].Journal of Tianjin Medical University,2015,21(03):328.
[2]孙健,孙建刚.复合达克罗宁胶浆对丙泊酚麻醉下瑞芬太尼抑制老年患者喉罩置入反应的影响[J].天津医科大学学报,2021,27(01):52.
　SUN Jian,SUN Jian-gang.Effects of dyclonine gel on the remifentanil under propofol anesthesia to inhibit laryngeal mask insertion in elderly patients[J].Journal of Tianjin Medical University,2021,27(03):52.

备注/Memo

备注/Memo:

作者简介 张杨（1982-），男，主治医师，硕士在读，研究方向：临床麻醉；通信作者：于泳浩，E-mail：yuyonghao@126.com.

 

常用功能

更新日期/Last Update: 2015-05-27