|本期目录/Table of Contents|

[1]许娇娇,等. 中国南海海绵Axinella sp.中化学成分的研究[J].天津医科大学学报,2015,21(03):217-219.
 XU Jiao-jiao,GU Qiong,et al.Studies on chemical constitunents in the South China Sea marine sponge Axinella sp.[J].Journal of Tianjin Medical University,2015,21(03):217-219.
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 中国南海海绵Axinella sp.中化学成分的研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
217-219
栏目:
基础医学
出版日期:
2015-05-20

文章信息/Info

Title:
Studies on chemical constitunents in the South China Sea marine sponge Axinella sp.
文章编号:
1006-8147(2015)03-0217-03
作者:
 许娇娇 1 2顾 琼1 2王 佳1 2赵 川3段宏泉1 23乔 卫1 2唐生安1;  2
 (1.天津医科大学药学院,天津300070; 2.天津市临床药物关键技术重点实验室,天津300070; 3.天津医科大学基础医学研究中心,天津300070)
Author(s):
XU Jiao-jiao1 2 GU Qiong1 2 WANG Jia1 2 ZHAO Chuan3 DUAN Hong-quan 1 2 3 QIAO Wei1 2 TANG Sheng-an1 2
(1.School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 2.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China; 3.Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China)
关键词:
 南海海绵Axinella sp.结构鉴定溴代吡咯烷型生物碱
Keywords:
 marine sponge Axinella sp. structure identification bromopyrrole alkaloids

分类号:
R282.77
DOI:
-
文献标志码:
A
摘要:
目的:研究中国南海海绵Axinella sp.的化学成分。方法:用硅胶柱色谱、制备薄层色谱、凝胶柱色谱和半制备HPLC等分离纯化,并采用质谱、核磁共振波谱等有机波谱方法鉴定化合物的结构。结果:从海绵Axinella sp.中分离的7个化合物,依次鉴定为debromohymenialdisine (1), hymenialdisine (2), aldisin (3), 3-bromoaldisin (4), 尼克酰胺 (5), 胸腺嘧啶 (6), 尿嘧啶 (7)。结论:化合物14是海绵中特有的溴代吡咯烷型生物碱,化合物5, 6, 7为首次从该属海绵中分离得到。
Abstract:
Objective: To investigate the chemical constituents in the South China Sea marine sponge Axinella sp. Methods: Various chromatography techniques (silica gel, preparative TLC, Sephadex LH-20 and semi-preparative HPLC) were performed to isolate and purify the extracts. The structures were identified mainly by extensive spectral data analysis. Results: Seven compounds were isolated and their structures were identified as debromohymenialdisine (1), hymenialdisine (2), aldisin (3), 3-bromoaldisin (4), niacinamide (5), thymine (6), uracil (7). Conclusion: Compounds 1-4 are specific bromopyrrole alkaloids of marine sponges, and compounds 5, 6, 7 are isolated for the first time from the genus Axinella.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目(81102371), 天津市自然科学基金资助项目(10JCYBJC15000)

作者简介 许娇娇(1989-)女,硕士在读,研究方向:天然产物有效分离、分析研究;通信作者:唐生安,E-mail: tangshengan@tijmu.edu.cn







更新日期/Last Update: 2015-05-27