|本期目录/Table of Contents|

[1]许德芳,余剑波,牟 戎,等.不同全麻药物对体外循环患者氧化应激反应影响的比较[J].天津医科大学学报,2015,21(04):328-331.
 XU De-fang,YU Jian-bo,MU Rong,et al.Effect of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting[J].Journal of Tianjin Medical University,2015,21(04):328-331.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21
期数:
2015年04期
页码:
328-331
栏目:
临床医学
出版日期:
2015-07-15

文章信息/Info

Title:
Effect of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting
文章编号:
1006-8147(2015)04-0328-04
作者:
 许德芳12 余剑波2牟 戎1张 丽1王冰舒1周春晶1 王 方1
(1.天津医科大学第四中心临床学院麻醉科,天津市第四中心医院麻醉科,天津300140;2.天津医科大学南开临床学院麻醉科,天津市南开医院麻醉科,天津300100)
Author(s):
XU De-fang12 YU Jian-bo2MU Rong1 ZHANG Li 1 WANG Bing-shu 1 ZHOU Chun-jing 1 WANG Fang 1
(1.Department of Anesthesiology,The Fourth Center Clinical College ,Tianjin Medical Univercity, The Fourth Center Hospital of Tianjin ,Tianjin 300140,Chian;2. Department of Anesthesiology,The Nan Kai Clinical College of Tianjin Medical Univercity, The Nan Kai Hospital of Tianjin,Tianjin 300100, China)
关键词:
丙泊酚七氟烷依托咪酯氧化应激体外循环
Keywords:
propofulsevofluraneetomidateoxidative stresscardiopulmonary bypass
分类号:
R614
DOI:
-
文献标志码:
A
摘要:
 目的:观察不同麻醉方式对体外循环冠状动脉搭桥术(CABG)患者围术期氧化应激反应的影响。方法:择期拟行体外循环下CABG术患者45例,随机分为3组(每组15例):丙泊酚组(P组)、依托咪酯组(E组)和七氟烷组(S组)。分别于麻醉前、手术切皮时、体外循环开始前、手术结束时、术后6 、24 、48 、72 h(T0~7)记录患者心率(HR)和平均动脉压(MAP),并于T0、T4~7时取血测定过氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)含量。结果:3组患者在T5和T6时点SOD、CAT和GSH-Px活性均低于术前(P<0.05)。S组在T7 时点SOD和GSH-Px活性依然低于术前(P<0.05)。E组和S组的SOD、CAT和GSH-Px活性在术后均不同程度低于P组(P<0.05)。与E组相比,S组SOD、 CAT和GSH-Px活性在术后有不同程度升高(P<0.05)。结论:与七氟烷和依托咪酯相比较,丙泊酚能更好地对抗体外循CABG术围术期的氧化应激反应。
Abstract:
 Objective:To observe effects of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting (CABG)operation. MethodsForty five patients undergoing coronary artery bypass grafting operation with cardiopulmonary bypass were randomly divided into 3 groups(n=15):propofol group (group P),etomidate group (group E) and sevoflurane group (group S). At the times before anesthesia, incision, and CPB, by the end of operation, 6,24,48,72 h after operation (T0-7),heart rate (HR) and mean arterial pressure (MAP) were recorded. At T0 and T4 to T7, the activity of superoxide dismutase (SOD) and catalase (CAT) were measured. ResultsThe activities of SOD,CAT and GSH-Px at T5 and T6 in 3 groups were lower than those at T0P <0.05).The activities of SOD and GSH-Px at T7 in group S were also lower than those at T0 P <0.05). Compared with group E and group S ,the activities of SOD,CAT and GSH- Px were lower than group P in different degrees after the operation(P <0.05). Compared with group E , the activities of SOD,CAT and GSH- Px in group S were significantly increased after the operation to various degrees(P <0.05). Conclusion Propofol may have better effect on oxidative stress of CABG.

参考文献/References:

[1]Wang Y C, Zhang S, Du T Y, et al. Hyperbaric Oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte[J].Brain Res,2010,1323:149

[2]王海云,王国林,于泳浩,等.丙泊酚后处理对体外循环冠脉旁路移植术患者心肌缺血再灌注损伤的影响[J].天津医药,2010,38(4):266

[3]邹捍东,吴灵潝,周青山,等.异丙酚和七氟烷复合麻醉对重症心脏瓣膜病心内直视术患者心肌损伤影响的比较[J].中华麻醉学杂志,2012,32(8):961-964

[4]Miller R D.米勒麻醉学[M].北京:北京大学医学出版社,2006

[5]张日英,邓劲松,李波,等.依托咪酯乳剂全凭静脉全麻在重症瓣膜手术中的应用[J].中华全科医学,2013,11(11):1702

[6]张诗海,姚尚龙.异丙酚在成人体外循环中抗氧化效应的研究[J].中华麻醉学杂志,2000,20(10):594

[7]Dalal A A, Candrilli S D, Davis K L. Outcomes and costs associated with initial maintenance therapy with fluticasone propionate-salmeterol xinafoate 250 microg/50 microg combination versus tiotropium in commercially insured patients with COPD[J].Manag Care,2011,20(8):46

[8]Kumar P, Bhandari U. Protective effect of Trigonella foenum-graecum Linn. on monosodium glutamate-induced dyslipidemia and oxidative stress in rats[J].Indian J Pharmacol,2013,45(2):136

[9]Xu B, Xu Z F, Deng Y, et al. Protective effects of MK-801 on methylmercury-induced neurol injury in rat cerebral cortex:involvement of oxidative stress and glutamate metabolism dysfunction[J].Toxicology,2012,300(3):112

[10]刘骥,李金宝,邓小明.靶控输注依托咪酯用于全身麻醉维持的可行性研究[J].临床麻醉学杂志,2009,25(5):389

[11]Vinclair M, Broux C, Faure P, et al.Duration of adrenal inhibition following a single dose of etomidate in critically ill patients[J].Intensive Care Med,2008,34(4):714

[12]Kamp R, Etomidate K J.Sepsis,and adrenal function:not as bad as we thought[J].Crit Care,2007,11(3):145

[13]张朝旭,来虹,陈强,等.依托咪酯后处理对大鼠局灶性脑缺血再灌注损伤氧化应激反应的影响[J].中国药物与临床,2013,13(11):1422

[14]张红涛,杨勇,于泳浩,等.依托咪酯乳剂复合瑞芬太尼全凭静脉麻醉的临床观察[J].天津医药,2011,39(9):849

[15]吴敏,庞宏宣,张文斌,等.依托咪酯对体外循环心脏直视手术患者血浆SOD和MDA的影响[J].广东医学,2011,32(13):1751

 

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备注/Memo

备注/Memo:
作者简介 许德芳(1982-),女,住院医师,硕士在读,研究方向:临床麻醉;通信作者:余剑波,E-mail: jianboyu99@sina.com。
更新日期/Last Update: 2015-07-17