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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

26卷

期数:

2020年05期

页码:

440-444

栏目:

临床医学

出版日期:

2020-09-20

文章信息/Info

Title:

Retrospective study on risk factors for concurrent intestinal perforation in neonates with necrotizing enterocolitis

文章编号:

1006-8147(2020)05-0440-05

作者:

王元惠¹; 王皓洁¹; 2; 刘志杰²; 詹江华³

（1.天津医科大学研究生院，天津300070；2.乌鲁木齐儿童医院新生儿外科，乌鲁木齐830000；3.天津市儿童医院普通外科，天津300074）

Author(s):

WANG Yuan-hui¹; WANG Hao-Jie¹; 2;  LIU Zhi-jie²;  ZHAN Jiang-hua³

（1.Graduate School, Tianjin Medical University, Tianjin 300070, China; 2.Department of Neonatal Surgery, Ulumuqi Children′s Hospital, Ulumuqi 830000, China; 3.Department of General Surgery, Tianjin Children′s Hospital, Tianjin 300074, China）

关键词:

新生儿; 坏死性小肠结肠炎; 肠穿孔; 危险因素

Keywords:

neonate; necrotizing enterocolitis; intestinal perforation; risk factors

分类号:

R726.5

DOI:

-

文献标志码:

A

摘要:

目的：探讨新生儿坏死性小肠结肠炎（NEC）伴发肠穿孔的危险因素。方法：回顾性分析55例NEC伴发肠穿孔患儿（NEC伴发肠穿孔组）的临床资料，并随机选取110例同期收治的NEC未伴发肠穿孔 患儿为对照组，采用单因素和多因素Logistic回归分析，总结NEC伴发肠穿孔的危险因素。结果：NEC并发败血症（OR=2.557）、凝血功能障碍（OR=4.075）、低钾血症（OR=5.180）是肠穿孔的独立危险 因素（P＜0.05），而高胎龄（OR=0.884）为保护因素（P＜0.05）。上述3个独立危险因素联合对NEC伴发肠穿孔的预测价值最高，ROC曲线下面积为0.875，特异性和灵敏性分别为79.2%、81.8%。结论： NEC伴发败血症、凝血功能障碍、低钾血症是NEC伴发肠穿孔的独立危险因素。三者联合对NEC伴发肠穿孔有较高预测价值。

Abstract:

Objective: To explore the risk factors for necrotizing enterocolitis(NEC) with intestinal perforation in neonates. Methods: The clinical data of 55 NEC patients with intestinal perforation(Group 1) were retrospectively analyzed, and 110 children diagnosed as NEC without intestinal perforation(Group 2) admitted at the same time were randomly selected as the control group. Univariate and multivariate logistic regression analysis methods were used to summarize the risk factors of NEC with intestinal perforation. Results: NEC complicated with sepsis(OR=2.557), coagulation dysfunction(OR=4.075) and hypokalemia(OR=5.180) were independent risk factors for concurrent intestinal perforation (P<0.05), and high gestational age(OR=0.884) was the protective factor(P<0.05). The combination of the three independent risk factors mentioned above has the highest predictive value for NEC with intestinal perforation. The area under the curve of ROC was 0.875, and the specificity and sensitivity were 79.2% and 81.8%, respectively. Conclusion: NEC complicated with sepsis, coagulation dysfunction and hypokalemia are independent risk factors for NEC with intestinal perforation. The combination of three independent risk factors has a high predictive value for NEC with intestinal perforation.

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备注/Memo

备注/Memo:

基金项目 新疆维吾尔自治区自然科学基金（2019D01A12）
作者简介 王元惠（1990-），女，医师，硕士在读，研究方向：儿科学；
通信作者：詹江华，E-mail：zhanjianghuatj@163.com。

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更新日期/Last Update: 2020-09-18