|本期目录/Table of Contents|

[1]连喜院,郭会萍,关楠,等.影响经胃管LISA技术治疗新生儿呼吸窘迫综合征疗效的因素分析[J].天津医科大学学报,2021,27(02):147-149.
 LIAN Xi-yuan,GUO Hui-ping,GUAN Nan,et al.Analysis of factors affecting the efficacy of transgastric tube LISA technique in the treatment of neonatal respiratory distress syndrome[J].Journal of Tianjin Medical University,2021,27(02):147-149.
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影响经胃管LISA技术治疗新生儿呼吸窘迫综合征疗效的因素分析(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
27
期数:
2021年02期
页码:
147-149
栏目:
临床医学
出版日期:
2021-03-15

文章信息/Info

Title:
Analysis of factors affecting the efficacy of transgastric tube LISA technique in the treatment of neonatal respiratory distress syndrome
文章编号:
1006-8147(2021)02-0147-03
作者:
连喜院郭会萍关楠张建成唐建辉何康康
(甘肃医学院附属医院新生儿科,平凉744000)
Author(s):
LIAN Xi-yuanGUO Hui-pingGUAN NanZHANG Jian-chengTANG Jian-huiHE Kang-kang
(Department of Newborn,The Hospital of Gansu Medical College,Pingliang 744000,China)
关键词:
呼吸窘迫综合征新生儿微创注入肺表面活性物质技术
Keywords:
respiratory distress syndromenewbornless invasive surfactant administration
分类号:
R722.19
DOI:
-
文献标志码:
A
摘要:
目的:探讨影响经改良胃管微创注入肺表面活性物质(LISA)技术治疗新生儿呼吸窘迫综合征疗效的相关影响因素。方法:纳入2015年6月—2020年6月住院治疗的80例新生儿呼吸窘迫综合征(NRDS)患儿作为研究对象,进行经胃管LISA技术治疗。按照是否需要再插管通气,分为有效组68例,无效组12例。收集患儿的一般资料、临床资料、治疗过程等数据。对有意义的指标进行多因素Logistic分析。结果:无效组早产儿、双胎/多胎妊娠、剖宫产、胎儿宫内窘迫的比例明显高于有效组(?字2=8.162、7.843、7.517、9.461,均P<0.05);无效组糖皮质激素比例明显低于有效组(?字2=9.043,P<0.05);无效组胎龄、出生体重、1 min Apgar评分、5 min Apgar评分、生后72 h红细胞比容、pH值、O2分压明显低于有效组(?字2=2.639、4.036、5.020、4.130、2.160、2.156、4.326,均P<0.05);无效组胸部X线(重度)、CO2分压明显高于有效组(?字2=11.060、11.060,均P<0.05)。Logistic多因素分析结果显示,胎龄(OR=2.063,P=0.003)、糖皮质激素(OR=0.846,P=0.001)、1 min Apgar评分(OR=0.460,P=0.015)、胸部X线等级(OR=0.552,P=0.006)均是NRDS的影响因素。结论:糖皮质激素为影响LISA技术治疗疗效的保护因子,而胎龄、1 min APgar评分、胸部X线等级是危险因子。
Abstract:
Objective: To investigate the related factors that affect the efficacy of the modified gastric tube minimally invasive injection of pulmonary surfactant(LISA) technology in the treatment of neonatal respiratory distress syndrome. Methods: A total of 80 children with neonatal respiratory distress syndrome(NRDS) hospitalized from June 2015 to June 2020 were enrolled as the research subjects,and were treated with transgastric tube LISA technology. According to the need for reintubation,68 cases were divided into effective group and 12 cases were ineffective group. General data,clinical data,treatment process and other data of children were collected. Multivariate Logistic analysis was used to analyze the significant indexes. Results: The proportion of premature babies,twin/multiple pregnancy,cesarean section,and intrauterine distress in ineffective group were significantly higher than those in effective group(?字2=8.162,7.840,7.517,9.461,all P<0.05); the proportion of glucocorticoids in ineffective group was significantly lower than effective group(?字2=9.043,P<0.05);in ineffective group,gestational age,birth weight,1 min Apgar score,5 min Apgar score,72 h postnatal hematocrit,pH,and O2 partial pressure were significantly lower than those in effective group( ?字2=2.639,4.036,5.020,4.130,2.160,2.156,

参考文献/References:

[1] 王晓磊,梅花. 肺表面活性蛋白-B、三磷酸腺苷结合盒转运子A3基因变异与新生儿呼吸窘迫综合征的研究进展[J].中华围产医学杂志,2016,19(2):157
[2] 赵振彤,臧小英. 布地奈德联合肺表面活性物质治疗胎粪吸入综合征对血气指标的影响及安全性分析[J].天津医科大学学报,2020,26(3):249
[3] 刘银芝,张帆,颜卫群,等. 肺表面活性物质治疗36例足月新生儿呼吸窘迫综合征临床分析[J].中国医师杂志,2015,17(7):1046
[4] 向蕊,曲书强. 糖皮质激素联合肺表面活性物质治疗新生儿呼吸窘迫综合征研究进展[J]. 中国医师进修杂志,2019(12):1141
[5] 李欣颖. 新生儿呼吸窘迫综合征(NRDS)肺表面活性物质替代疗法的护理及效果观察[J]. 护士进修杂志,2015,30(15):1425
[6] 王彦蕊,王铭杰,余小河,等. 影响INSURE技术治疗早产儿呼吸窘迫综合征疗效因素的临床分析[J].临床儿科杂志,2015,33(7):621
[7] 殷爱云,张永燕. LISA技术对新生儿呼吸窘迫综合征患儿血气指标及Toll样受体-4水平影响[J]. 临床军医杂志,2020,48(6):704
[8] 霍梦月,梅花,张钰恒,等. 低侵入性肺表面活性物质治疗技术治疗新生儿呼吸窘迫综合征有效性和安全性的Meta分析[J].中国当代儿科杂志,2020,22(7):721
[9] 邵肖梅,叶鸿瑁,邱小油. 实用儿科学[M].4版.北京:人民卫生出版社,2011:395-398
[10] 万秋凤,邓春. 新生儿呼吸窘迫综合征病因学研究进展[J].儿科药学杂志,2015,21(2):60
[11] 高金红. PS治疗新生儿MAS和NRDS的疗效观察及安全性评价[J].临床肺科杂志,2015,20(11):2080
[12] 李珊,王颖,桑田,等. 早产儿肺表面活性物质微创给药随机对照研究[J].中华新生儿科杂志,2020(2):113
[13] 王波,朱明理,陈小江. LISA技术联合持续气道正压通气治疗早产儿呼吸窘迫综合征的临床观察[J].中华新生儿科杂志,2020(1):44
[14] 徐芬,罗俊,黎红平,等. LISA技术治疗新生儿呼吸窘迫综合征有效性的系统评价[J]. 临床儿科杂志,2017,35(3):223
[15] 罗四维,孙波. 产前应用糖皮质激素对超早产儿预后影响的研究进展[J]. 中华围产医学杂志,2019(12):899

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备注/Memo

备注/Memo:
作者简介 连喜院(1974-),男,主任医师,学士,研究方向:新生儿感染及呼吸系统疾病;通信作者:郭会萍,E-mail:911429109@qq.com。
更新日期/Last Update: 2021-03-10