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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年01期

页码:

50-54

栏目:

临床医学

出版日期:

2018-01-20

文章信息/Info

Title:

Evaluation value?of preoperative peripheral blood NLR and PLR? on prognosis of? gastric cancer

文章编号:

1006-8147(2018)01-0050-05

作者:

赵忠治; 王金淼; 魏颖; 戚 峰

（天津医科大学总医院普通外科，天津 300052）

Author(s):

ZHAO Zhong-zhi; WANG Jin-miao; WEI Ying; QI Feng

(Department of General Surgery， General Hospital,Tianjin Medical University，Tianjin 300052,China)

关键词:

胃癌; 中性粒细胞与淋巴细胞计数比值; 血小板与淋巴细胞计数比值; 预后

Keywords:

gastric cancer;  neutrophil /lymphocyte ratio; platelet/lymphocyte ratio; prognosis

分类号:

R604

DOI:

-

文献标志码:

A

摘要:

目的：探讨术前外周血中性粒细胞与淋巴细胞计数比值（NLR）和血小板与淋巴细胞计数比值（PLR）对胃癌预后的评估价值。方法：收集154例具有完整临床病理资料的胃癌患者，采用ROC曲线分析cutoff值，X²检验、U检验比较不同分组之间的差异，Kaplan-Meier法计算生存率，COX回归模型多因素分析影响患者预后独立风险因素。结果：随访154位患者中失访患者12位，纳入生存分析的患者共142位，其中1年、3年、5年生存率分别为75％、49％、32％。单因素分析示：肿瘤大小（P=0.025）、分化类型（P=0.021）、浸润深度（P=0.007）、淋巴结分期（P＜0.001）、淋巴结转移率（P＜0.001）、TNM分期（P＜0.001）、PLR（P＜0.001）、NLR（P＜0.001）、手术方式（P=0.013）为影响胃癌患者预后的危险因素；多因素分析示：淋巴结转移率（P=0.004）、TNM分期（P=0.005）、PLR（P=0.001）可能为影响胃癌预后的独立危险因素。结论：PLR、NLR可以用来评价患者预后，PLR可能为影响预后总生存率的独立危险因素。

Abstract:

Objective ：To examinewhetherneutrophil /lymphocyte ratio (NLR) andplatelet/lymphocyte ratio(PLR) have prognostic value in preoperative peripheral blood of patients undergoing gastric cancer resection. Methods： One hundred and fifty-four gastric cancer patients with complete clinical and pathological data were reviewed.The cutoff values ??were analyzed by ROC curve.The differences between groups were compared using chi-square test and U test. The Kaplan-Meier method was used to calculate the survival rate. The COX regression model was applied to analyze the independent prognostic risk factors, which may affect the survival rate.Results： One hundred and forty-two cases were followed up.The 1-year, 3-year and 5-year survival rates were 75%, 49% and 32%， respectively. Tumor size (P = 0.025), tumor differentiation type (P = 0.021), depth of tumor invasion (P = 0.007), lymph node staging (P<0.001), lymph node metastasis rate (P<0.001), TNM staging (P<0.001), PLR (P<0.001)，NLR (P<0.001) and surgical approach (P = 0.013) were significantly correlated with survival rate by univariate analysis. Multivariate analysis showed that lymph node metastasis rate (P = 0.004), TNM staging (P = 0.005), PLR (P = 0.001) could be independent risks factor for the prognosis of gastric cancer. Conclusion: PLR and NLR can be used to evaluate the prognosis of patients. PLR may be an independent risk factor for the overall survival rate.

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备注/Memo

备注/Memo:

作者简介赵忠治（1991-），男，硕士在读，研究方向：外科学（普外）；通信作者：戚峰，E-mail: qf@medmail.com.cn。

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更新日期/Last Update: 2018-01-19