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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年02期

页码:

145-147,155

栏目:

出版日期:

2018-03-20

文章信息/Info

Title:

Value of measuring uKIM，IL-6 and T-cell subsets in sepsis patients with acute kidney injury

作者:

杨宏伟; 牛文彦

天津医科大学免疫学系，天津 300070

Author(s):

YANG Hong-wei;  NIU Wen-yan

Department of Immunology，Tianjin Medical University, Tianjin 300070, China

关键词:

脓毒症; 急性肾损伤; IL-6; T细胞亚群; 肾损伤分子-1

Keywords:

sepsis; acute kidney injury; interleukin-6; T-cell subsets; kidney injury molecule-1

分类号:

R631

DOI:

-

文献标志码:

A

摘要:

目的：研究尿肾损伤分子-1（uKIM-1）、血清肌酐（sCr）、白介素-6（IL-6）及T细胞亚群在脓毒症致急性肾损伤（ AKI）中的临床应用价值。方法：选择 ICU脓毒症患者69 例，根据有无肾功能损害分为脓毒症急性肾损伤组（AKI组）、非肾损伤组（非AKI组），其中AKI组患者39例，非AKI组患者30例。选择同期门诊健康体检者30例作为对照组。测定研究对象入科0、6、24、48 h血清肌酐与uKIM浓度以及入科24 h血清IL-6、T细胞亚群浓度，根据24 h内最差临床指标计算急性生理和慢性健康计算（APACHEⅡ）评分；采用统计软件SPSS13.0进行统计学分析。结果：脓毒症AKI组患者sCr、uKIM-1和血清IL-6检测结果均明显高于脓毒症非AKI组(P均<0.05)，与sCr诊断AKI时间相比，uKIM-1能更早地诊断脓毒症急性肾损伤，且IL-6、uKIM-1与APACHEⅡ评分呈正相关。AKI组与非AKI组患者，外周血CD3+T、CD4+T和CD8+T细胞及CD4+T/CD8+T均明显低于对照组，AKI组低于非AKI组，差异均有统计学意义（P均<0.05）。结论：uKIM-1、血清IL-6及T细胞亚群监测可用于评估脓毒症致急性肾损伤病情及预后，uKIM-1比sCr对脓毒症急性肾损伤有更好的诊断效能。

Abstract:

Objective: To analyze the relationship among the expression levels of kidney injury molecule-1(KIM-1)，creatinine，interleukin-6，and T-cell subsets in patients with acute kidney injury(AKI) induced by sepsis. Methods： Sixty-nine patients with sepsis admitted to ICU were divided into non-AKI group(n =30) and AKI group(n =39). Thirsty healthy people were also enrolled as healthy control group. The serum creatinine，uKIM，IL-6，T-cell subsets and acute physiology and chronic health evaluation(APACHE II) score were compared between 2 group, and the correlations among them were analyzed . Results：The blood level of creatinine, KIM and IL-6 were significantly higher in AKI group than those in non-AKI group. In AKI group, the CD3+T, CD4+T, CD8+T and CD4+T/CD8+T were significantly lower than those in non-AKI group. The differences were significantly different between the patients in the two groups. Conclusion：The blood level of KIM and IL-6 and the changes of T-cell subsets could be used to evaluate the degree of the disease and its prognosis. uKIM is more affected than creatinine.

参考文献/References:

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备注/Memo

备注/Memo:

文章编号 １００６－８１４７（２０18）０2-0145-03
作者简介 杨宏伟（1971-），女，主任技师，硕士在读，研究方向：免疫专业；E-mail：yanghongwei1971@sina.com。

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更新日期/Last Update: 2018-03-20