|本期目录/Table of Contents|

[1]陈海燕 综述,姜埃利 审校.急性肾损伤的生物标志物——血红素加氧酶1[J].天津医科大学学报,2017,23(05):483-封3.
点击复制

急性肾损伤的生物标志物——血红素加氧酶1(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23
期数:
2017年05期
页码:
483-封3
栏目:
综述
出版日期:
2017-09-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2017)05-0483-03
作者:
陈海燕 综述姜埃利 审校
(天津医科大学第二医院肾脏病血液净化科,天津300211)
Author(s):
-
关键词:
急性肾损伤血红素加氧酶1肾功能衰竭细胞保护作用氧化应激
Keywords:
-
分类号:
R692.5
DOI:
-
文献标志码:
A
摘要:
急性肾损伤(?AKI)是临床常见疾病,特别是危重病人,其发病率和死亡率均较高。AKI的病理生理过程复杂,涉及多种途径,包括炎症、细胞的自噬、细胞周期的变化和氧化应激等。最近的证据表明对肾脏的单一严重损伤可导致慢性肾脏病的发生,因此,必须及时有效的治疗AKI。在这篇综述中,有证据表明血红素加氧酶1(heme oxygenase 1,HO-1)在动物AKI模型中的保护效应。HO-1调节氧化应激、细胞自噬和炎症,并通过直接和间接机制调节细胞周期的进程。
Abstract:
-

参考文献/References:

[1]Ryter S W, Choi A M. Targeting heme oxygenase-1 andcarbon monoxide for therapeutic modulation of inflammation[J]. Transl Res, 2016, 167(1):7

[2] Leaf D E, Body S C, Muehlschlegel J D, et al. Lengthpolymorphisms in heme oxygenase-1 and AKI after cardiac surgery[J]. J Am SocNephrol, 2016, 27(11):3291

[3] Rabb H, Griffin M D, McKay D B, et al. Inflammation inAKI: current understanding, key questions, and knowledge gaps[J]. J Am SocNephrol, 2016, 27(2):371

[4]Kovtunovych G, Ghosh M C, Ollivierre W, et al. Wild-typemacrophages reverse disease in heme oxygenase 1-deficient mice[J]. Blood, 2014, 124(9):1522

[5]Kapturczak M H, Wasserfall C, Brusko T, et al. Hemeoxygenase-1 modulates early inflammatory responses: evidence fromthe heme oxygenase-1-deficient mouse[J]. Am J Pathol, 2004, 165(3):1045

[6] Hull T D, Kamal A I, Boddu R, et al. Heme oxygenase-1regulates myeloid cell trafficking in AKI[J]. J Am SocNephrol,2015, 26(9):2139

[7]Tracz M J, Juncos J P, Croatt A J, et al. Deficiency of hemeoxygenase-1 impairs renal hemodynamics and exaggerates systemicinflammatory responses to renal ischemia[J]. Kidney Int, 2007, 72(9):1073

[8]Bolisetty S, Zarjou A, Hull T D, et al. Macrophage andepithelial cell H-ferritin expression regulates renal inflammation[J]. Kidney Int, 2015, 88(1):95

[9] Park D J, Agarwal A, George J F. Heme oxygenase-1expression in murine dendritic cell subpopulations: effect onCD81 dendritic cell differentiation in vivo[J]. Am J Pathol, 2010, 176(6):2831

[10] Brusko T M, Wasserfall C H, Agarwal A, et al. An integral role for heme oxygenase-1 and carbonmonoxide in maintaining peripheral tolerance by CD41CD251regulatory T cells[J]. J Immunol, 2005, 174(9):5181

[11]Bellner L, Marrazzo G, van Rooijen N, et al. Heme oxygenase-2 deletionimpairs macrophage function: implication in wound healing[J]. FASEB J, 2015, 29(1):105

[12]Megyesi J, Andrade L, Vieira J M Jr, et al. Positive effect of the induction of p21WAF1/CIP1 onthe course of ischemic acute renal failure[J]. Kidney Int, 2001, 60(6):2164

[13]Inguaggiato P, Gonzalez-Michaca L, Croatt A J, et al. Cellular overexpression of hemeoxygenase-1 up-regulates p21 and confers resistance to apoptosis[J]. Kidney Int, 2001, 60(6):2181

[14] Gonzalez-Michaca L, Farrugia G, Croatt A J, et al. Heme: a determinant of life and death in renal tubularepithelial cells[J]. Am J Physiol Renal Physiol, 2004, 286(2):F370

[15] Kim S Y, Kang H T, Choi H R, et al. Biliverdin reductaseA in the prevention of cellular senescence against oxidativestress[J]. ExpMol Med, 2011, 43(1):15

[16] Wang L, Zhang Y, Yuan L, et al. Cyclindependentkinase inhibitor p18INK4c is involved in protectiveroles of heme oxygenase-1 in cisplatin-induced acute kidneyinjury[J]. Int J Mol Med, 2014, 34(3):911

[17]Kashani K, Al-Khafaji A, Ardiles T, et al. Discovery andvalidation of cell cycle arrest biomarkers in human acute kidneyinjury[J]. Crit Care, 2013, 17(1):R25

[18] Nath K A, Haggard J J, Croatt A J, et al. The indispensability of heme oxygenase-1 in protectingagainst acute heme protein-induced toxicity in vivo[J]. Am J Pathol, 2000, 156(5):1527

[19]Gunnerson KJ, Shaw AD, Chawla LS, et al. TIMP2*IGFBP7 biomarker panel accurately predicts acute kidneyinjury in high-risk surgical patients[J]. J Trauma Acute Care Surg,2016, 80(2):243-249

[20]Zager R A, Johnson A C, Becker K. Plasma and urinaryheme oxygenase-1 in AKI[J]. J Am SocNephrol, 2012, 23(6):1048

[21] Li Z, Xu Y, Liu X, et al. Urinary hemeoxygenase-1 as a potential biomarker for early diabetic nephropathy[J]. Nephrology (Carlton), 2016, 22(1):58

相似文献/References:

备注/Memo

备注/Memo:
作者简介 陈海燕(1977-),女,主治医师,博士,研究方向:慢性肾脏病及其并发症的诊治;通信作者:姜埃利,E-mail:carlos_j@126.com
更新日期/Last Update: 2017-09-21