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[1]杨蕊,许华,王兵,等.IL-18在脓毒症及脓毒症休克中预测死亡的作用[J].天津医科大学学报,2018,24(02):142-144.
　YANG Rui,XU Hua,WANG Bing,et al.Role of IL-18 in predicting mortality of patients with sepsis and septic shock[J].Journal of Tianjin Medical University,2018,24(02):142-144.
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IL-18在脓毒症及脓毒症休克中预测死亡的作用(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年02期
页码:
142-144
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
Role of IL-18 in predicting mortality of patients with sepsis and septic shock
作者:
杨蕊1; 许华2; 王兵2; 王勇强2
1．天津医科大学一中心临床学院重症医学科，天津300192；2．天津市第一中心医院重症医学科， 天津市急救医学研究所，天津300192
Author(s):
YANG Rui1;  XU Hua2;  WANG Bing2;  WANG Yong-qiang2
1．Department of Critical Care Medicine, The First Center Clinical College , Tianjin Medical University, Tianjin 300192, China; 2．Department of Critical Care Medicine, Tianjin First Center Hospital, Tianjin Institute of Emergency Medicine, Tianjin 300192,China
关键词:
脓毒症; 脓毒症休克; 死亡率; 炎症; IL-18
Keywords:
sepsis;  septic shock;  mortality;  inflammation;  IL-18
分类号:
R631
DOI:
-
文献标志码:
A
摘要:
目的：探讨脓毒症及脓毒症休克患者血浆炎症因子水平与患者死亡率的相关性。方法： 选取入住 ICU并确诊为脓毒症的患者51例（试验组），包括25例脓毒症患者及26例脓毒症休克患者；对照组为随机选取的入住ICU的非脓毒症且病情危重的患者20例。采用酶联免疫吸附试验分别检测试验组及对照组病人的血浆炎症因子IL-6、IL-8、IL-10、IL-18、IL-1β及TNF-α的浓度水平，同时根据APACHEⅡ、SOFA评分评估病情的严重程度。结果：与对照组相比，脓毒症患者组及脓毒症休克患者组IL-1β、IL-6、IL-8、TNF-α、IL-18浓度水平均有显著升高（P＜0.05）。比较脓毒症患者组及脓毒症休克患者组内生存者与死亡者血浆炎症因子水平发现，死亡者的IL-6、IL-8及IL-18浓度水平明显升高（P＜0.05）,其他炎症因子无明显升高（P＞0.05）。采用多变量Logistic回归分析显示IL-18是患者预后的独立影响因素。结论：IL-18对于脓毒症及脓毒症休克患者死亡的预测有十分重要的作用。
Abstract:
Objective: To investigate the association between mortality and inflammatory markers in patients with sepsis and septic shock. Methods: Eligible patients with sepsis were prospectively recruited and treated, including 25 sepsis patients and 26 septic shock patients. The control group contained 20 patients who were hospitalized in ICU without indication of sepsis. Serum levels of inflammatory mediators were measured(IL-6,IL-8,IL-10,IL-18,IL-1β,TNF-α). Furthermore, severity and organ dysfunction according to APACHEⅡ and SOFA were estimated. Results：The levels of IL-1β, IL-6, IL-8, IL-18 and TNF-α in experimental group were significantly increased compared with the control group(P＜0.05). By comparing the survivors and non-survivors in both sepsis group and septic shock group， the levels of IL-6, L-8 and IL-18 was significant increased (P＜0.05)，which did not occur in other inflammatory factors. Multivariate logistic regression analysis showed that the IL-18 were related to the mortality but independent of other inflammatory mediators in sepsis and septic shock(P＜0.05). Conclusion：IL-18 is significant in predicting the mortality in patients with both sepsis and septic shock.

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备注/Memo

备注/Memo:
文章编号 １００６－８１４７（２０18）０2-0142-03
基金项目 卫生部国家临床重点专科建设项目（2011-873）；天津市卫生和计划生育委员会攻关课题（14KG101）；天津市卫生和计划生育委员会重点课题（2014KR07）
作者简介 杨蕊（1991-），女，硕士在读，研究方向：急诊医学； 通信作者：王勇强，E-mail:yongqiangwang1962@sina.com。
更新日期/Last Update: 2018-03-20