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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年01期

页码:

32-35

栏目:

临床医学

出版日期:

2017-01-16

文章信息/Info

Title:

Differece between methionine PET and MR enhancement in? the range of glioblastoma multiforme

文章编号:

1006-8147（2017）01-0032-04

作者:

刘 龙¹; 赵景旺¹; 陈旨娟²; 贾 源¹; 郑金平¹; 王威汉¹; 王增光²; 杨卫东¹

（1.天津医科大学总医院神经外科，天津300052；2.天津市神经病学研究所，天津300052）

Author(s):

LIU Long¹;  ZHAO Jing-wang¹;  CHEN Zhi-juan²;  JIA Yuan¹;  ZHENG Jin-ping¹;  WANG Wei-han¹; WANG Zeng-guang²;  YANG Wei-dong¹

(1.Department of Neurosurgery,General Hospital,Tianjin Medical University,Tianjin 300052, China;2. Tianjin Neurological Institute, Tianjin 300052, China)

关键词:

共振成像; PET/CT;  蛋氨酸;  胶质母细胞瘤

Keywords:

magnetic resonance imaging;  positron emission tomography and computed tomography;  methionine;  glioblastoma

分类号:

R651

DOI:

-

文献标志码:

A

摘要:

目的: 探讨胶质母细胞瘤病变范围在MRI增强和MET-PET影像中的差异性。方法: 回顾性分析5例经手术确诊的胶质母细胞瘤患者临床资料。收集患者术前MRI 增强（3D扫描）和PET/CT检查（MET示踪剂）的影像资料。以 MRI增强3D-T1序列为参考，将PET图像与其配准。使用MRIcron软件勾画对比PET高摄取区和MRI增强区的病变范围，分析胶质母细胞瘤PET高摄取区与MRI增强区的分布特点。结果: 5例患者病理结果均为胶质母细胞瘤（WHO Ⅳ级）。经过影像配准对比发现，胶质母细胞瘤病变的MET高摄取范围大于MRI增强范围，MET高摄取图像整体呈偏心性、不均一性，MET高摄取区薄弱甚至缺如的部分，常对应着MRI线样强化、实体组织较少的病变部位。结论: 将MRI增强和PET影像配准对比分析，有助于发现胶质母细胞瘤整体的偏心性、不均一性，为最大范围手术切除肿瘤提供辅助指导作用。

Abstract:

Objective: To explore the difference between the metabolically active tumors assessed by positron emission tomography and the area of enhancement magnetic resonance imaging in patients with newly diagnosed glioblastoma（GBM）. Methods: Five patients with newly diagnosed GBM were included in this study. MET-PET and enhanced MRI were analyzed in MRIcron software, including coregistration and overlaying. The glioblastoma lesion distribution was compared and its discrepancy was concluded between PET and MRI enhancement. Results: All five patients were confirmed as glioblastoma multiforme by histopathological diagnosis. Volume the metabolically active tumor as shown by a MET uptake index of ≥1.3 was larger than the that of MRI enhancement. The image of MET was eccentric and asymmetric in general, and MET weak position was in correspondence to MRI linear enhancement or tumor with necrotic tissue. Conclusion: Coregistration and analysis of MRI with MET-PET may be helpful to determine that GBM is eccentric and asymmetric, and may also need further quantitative research to become a more general approach.

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备注/Memo

备注/Memo:

作者简介 刘龙（1989-），男，住院医师，硕士在读，研究方向：立体定向与功能神经外科；通信作者：杨卫东，E-mail: yangweidongshine@sina.com.

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更新日期/Last Update: 2017-01-16