|本期目录/Table of Contents|

[1]李美珍,上官可可,杨金荣,等.复方呋塞米螺内酯胶囊的处方筛选[J].天津医科大学学报,2016,22(02):171-175.
　LI Mei-zhen,SHANGGUAN Ke-ke,YANG Jin-rong,et al.Optimizing prescription of the compound furosemide and spironolactone capsules[J].Journal of Tianjin Medical University,2016,22(02):171-175.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年02期
页码:
171-175
栏目:
技术与方法
出版日期:
2016-03-20

文章信息/Info

Title:
Optimizing prescription of the compound furosemide and spironolactone capsules
文章编号:
1006-8147（2016）02-01671-05
作者:
? 李美珍1; 上官可可1;  杨金荣2; 房志仲2
(1.天津医科大学第二医院药剂科,天津 300211;2.天津医科大学药学院药剂学教研室,天津市临床药物关键技术重点实验室,天津 300070)
Author(s):
LI Mei-zhen 1;  SHANGGUAN Ke-ke1; YANG Jin-rong2; FANG Zhi-zhong2

(1.Department of Pharmacy,The Second Hospital, Tianjin Medical University,Tianjin 300211,China；2.Department of Pharmacy, College of Pharmacy, Tianjin Medical University, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics)，Tianjin 300070,China)

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关键词:

复方胶囊' target="_blank" rel="external">">复方胶囊; 呋塞米; 螺内酯; 处方筛选; ?2因子

' target="_blank" rel="external">">

Keywords:
"> "> 0;  0); "> "> compound capsules ">compound capsules ' target="_blank" rel="external">">; furosemide ;  spironolactone;  formulation optimization;  ?2 factor

分类号:
R9
DOI:
-
文献标志码:
A
摘要:

目的：利用均匀设计法及相关分析优选复方呋塞米螺内酯胶囊处方。方法：以不同处方配比的崩解剂、粘合剂、填充剂、润滑剂为载药辅料，以崩解时限、装量差异、体外溶出度等作为考察指标，采用均匀设计法及相关分析筛选最优处方。测定自制与市售制剂在不同溶出介质中的体外溶出度，并计算?2因子进行比较。结果:确定最佳处方中辅料的种类及其用量，羧甲基淀粉钠(CMS-Na)为崩解剂，水为粘合剂，微晶纤维素(MCC)、乳糖为填充剂，硬脂酸镁、滑石粉为润滑剂。自制与市售制剂在不同溶出介质中溶出度行为并无显著差异(50≤?2≤100)。结论:该试验筛选出的优化复方制备处方和工艺条件，所得颗粒均匀、硬度适宜，制得胶囊外观整洁、崩解迅速。

Abstract:
Objective: To Use uniform design method and correlation analysis to optimize the prescription of compound capsules. Methods: Many different formulations were designed by the uniform experimental of Statistics, the blank capsules of all formulations were made, and the disintegration time, the packing amount divergent, and dissolution experiments of capsule as inspection indexes were added to set up the best formulations. Determination of the dissolution of self-made and marketed preparations in different dissolution media, and calculation of the ?2 factor were carried out. Results: The kind and dosage of accessories in the best formulations were determined, CMS-Na was disintegrant, water was binding agent, MCC and lactose were used as fillers, and magnesium stearate and French chalk were used as lubricants. There was no significant difference in the dissolution behaviors of the self-made and marketed preparations in different dissolution media. Conclusion: The selected optimal preparation and the formulation of compound capsules have good process conditions, and the uniform particles, hardness is appropriate, the capsule appearance neat, sputtering quickly.

参考文献/References:

[1]王芳．利尿剂概述[J]．临床肾脏病杂志，2011，10（11）：484

[2]马艳华．呋塞米的临床新用途[J]．黔南民族医专学报，1998（2）：26

[3]张国胜．螺内酯的临床应用[J]．健康大视野·医学分册，2007，2（2）：23

[4]张芳，张兴元，张洁，等．醛固酮拮抗剂临床应用的研究[J]．滨州医学院学报，2010，33（5）：378

[5]贺秀玲．浅谈螺内酯的新用途[J]．中外健康文摘，2011，8（23）：286

[6]Birbarl A E, Daouk M M, Mukaddam-daher S. Efficacy and safety of lasilactone, a new combination diuretic, in essential hypertension[J]. General Pharmacology, 1987, 18(6): 609

[7]张崭，王玲，屈凌波．福多司坦胶囊的制备及其处方优化[J]．河南师范大学学报:自然科学版，2010，38（6）：98

[8]张树生，赵山山．头孢呋辛酯胶囊的制备工艺[J]．河北化工，2010，33（8）：47, 60．

[9]侯国枝，田治科，张茹英，等．巴洛沙星胶囊的制备工艺及溶出度研究[J]．中国药业，2009，18（12）：53

[10]史银基，刘砥威，石雪，等．克拉霉素胶囊中粘合剂及用量的确定[J]．新疆医学，2011，18（4）：132, 140

[11]冯李文．均匀设计法及其在新产品开发中的应用[J]．川化，2005，30（2）：18

[12]郭东星，仇丽霞，张满栋．均匀设计方法及其应用[J]．数理医药学杂志，2005，18（1）：69

[13]周涛．空心胶囊崩解时限的讨论[J]．中国药事，2002，16（9）：45

[14]郑琴，陈青阳，杨明，等．空胶囊的研究现状及解决中药胶囊吸潮问题的思考[J]．江西中医学院学报，2007，19（6）：74

[15]阳长明，侯世祥．药物溶出度研究进展[J]．中成药，2000，22（7）：53

[16]谢沐风，张启明，陈洁，等．国外药政部门采用溶出曲线评价口服固体制剂内在品质情况简介[J]．中国药事，2008，22（3）：257

[17]陈贤春，吴清，王玉蓉，等．关于溶出曲线比较和评价方法[J]．中国医院药学杂志，2007，27（5）：662

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备注/Memo

备注/Memo:
作者简介 李美珍（1986-）女，硕士，研究方向：临床药理学；通信作者：房志仲，E-mail:fangzhizhong@tmu.edu.cn。
更新日期/Last Update: 2016-03-24