|本期目录/Table of Contents|

[1]汪贤梅,张志强,唐 方.不同厂家及批次麻黄配方颗粒质量差异的研究[J].天津医科大学学报,2016,22(02):168-170.
　WANG Xian-mei,ZHANG Zhi-qiang,TANG Fang.Research on the quality differences of?mahuang formula granules between different manufacturers and? batches[J].Journal of Tianjin Medical University,2016,22(02):168-170.
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不同厂家及批次麻黄配方颗粒质量差异的研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年02期
页码:
168-170
栏目:
技术与方法
出版日期:
2016-03-20

文章信息/Info

Title:
Research on the quality differences of?mahuang formula granules between different manufacturers and? batches
文章编号:
1006-8147（2016）02-0168-03
作者:
汪贤梅1 ;  张志强2; 唐 方1
（天津医科大学总医院中医科,天津 300052; 2.天津红日药业股份有限公司, 天津 301700)
Author(s):
WANG Xian-mei1; ZHANG Zhi-qiang2; TANG Fang1
(1. Department of Traditional Chinese Medicine , General Hospital , Tianjin Medical University,Tianjin 300052, China;2. Tianjin Chase Sun Pharmaceutical.,TLD, Tianjin 301700 China)
关键词:
麻黄配方颗粒剂; 红外光谱; 高效液相色谱法; 麻黄碱; 伪麻黄碱
Keywords:
mahuang formula granules;  FTIR;  HPLC;  ephedrine;  d-pseudephedrine
分类号:
R92
DOI:
-
文献标志码:
A
摘要:
?目的：考察不同厂家及不同批次麻黄配方颗粒剂质量差异。方法：采用红外光谱（FTIR）法明确麻黄颗粒剂与麻黄对照药材成分的相似度；高效液相色谱法（HPLC）对其主要生物碱成分麻黄碱和伪麻黄碱进行含量测定，分析柱：WondaSilC18 (250 mm×4.6 mm,5 μm),流动相：乙腈-0.3%磷酸溶液（含0.05%三乙胺）（4:96，v:v）,流速：1.0 mL·min-1,柱温：30℃，检测波长：210 nm。结果：不同厂家各批次麻黄配方颗粒与麻黄对照药材红外特征图谱的相似度≥92%；不同品牌麻黄颗粒剂中，麻黄碱和伪麻黄碱含量存在显著性差异（P<0.01）；同厂家不同批次麻黄颗粒剂中麻黄碱和伪麻黄碱含量间存在差异，有统计学意义（P<0.05，P<0.01）。结论：不同厂家、同厂家不同批次麻黄配方颗粒剂中麻黄碱和伪麻黄碱含量存在显著差异。
Abstract:

Objective: To compare qualities of mahuang formula particles from different manufacturers and batches. Methods : First of all，the similarity of contrast medicinal material and mahuang formula granules of different manufacturers was defined by using the FTIR fingerprint. Then content of ephedrine and d-pseudephedrine in mahuang formula granules was determined with HPLC, chromatographic column was WondaSilC18 (250 mm×4.6 mm,5 μm), the mobile phase was V(methyl cyanide):V(0.3% ammonium dihydrogen phosphate solution including 0.05% triethylamine)=4:96, flow rates was 1.0 mL·min-1, the temperature was 30℃, and length of detection wave was 210 nm. Results: FTIR showed the similarity of all components between each sample and contrast medicinal material were higher than 92%. Comparison between different manufactures, therewere significant differences between?? ephedrine and d-pseudephedrine (P<0.010;? Comparison of? different batches of the same manfacturers? , there were differences of ephedrine and d-pseudephedrine ,with statistical significance(P<0.01,P<0.05). ?Conclusion: The contents of ephedrine and d-pseudephedrine of all samples from different manufacturers and different batches are significantly different.

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备注/Memo

备注/Memo:
?作者简介 汪贤梅(1989-),女，硕士在读，研究方向：中药有效成分含量分析；通信作者: 唐方, E-mailzhongyi3599@sina.com。
更新日期/Last Update: 2016-03-24