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[1]李 宁,马 骏.长链非编码RNA HOTAIR在膀胱癌中的表达及临床意义[J].天津医科大学学报,2016,22(02):126-128.
　LI Ning,MA Jun..Clinical significance of HOTAIR expression in patients with bladder cancer[J].Journal of Tianjin Medical University,2016,22(02):126-128.
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长链非编码RNA HOTAIR在膀胱癌中的表达及临床意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年02期
页码:
126-128
栏目:
基础医学
出版日期:
2016-03-20

文章信息/Info

Title:
Clinical significance of HOTAIR expression in patients with bladder cancer
文章编号:
1006-8147（2016）02-0126-03
作者:
李 宁; 马 骏
（天津医科大学公共卫生学院流行病与卫生统计学系，天津 300070）
Author(s):
LI Ning;  MA Jun.
(Department of Epidemiology and Health Statistics, School of Public Health, Tianjin Medical University, Tianjin 300070,China)
关键词:
长链非编码RNA;  HOTAIR;  膀胱癌
Keywords:
long non-coding RNA;  HOTAIR;  bladder cancer
分类号:
R737.14
DOI:
-
文献标志码:
A
摘要:
目的： 探讨长链非编码RNA HOTAIR在膀胱癌组织与癌旁正常组织的表达差异，了解HOTAIR与膀胱癌恶性程度、进展及预后的相关性。方法： 采用qRT-PCR方法检测88例膀胱癌组织与癌旁正常组织中HOTAIR RNA的差异表达，分析HOTAIR表达水平与患者临床病理特征的关系，采用Kapaln-Meier生存分析及COX 比例风险回归模型分析HOTAIR表达水平与膀胱患者预后的相关性。结果： 膀胱癌组织中HOTAIR RNA 表达明显高于癌旁正常组织，HOTAIR RNA高表达与肿瘤高分级及临床高分期有关（P<0.05），HOTAIR高表达组膀胱癌患者5年生存率明显低于HOTAIR低表达组（P<0.05），COX 回归分析提示HOTAIR RNA高表达可能为膀胱癌不良预后的独立危险因子之一。结论： 长链非编码RNA HOTAIR与膀胱癌发生发展及其恶性程度相关，HOTAIR可以作为预测膀胱癌患者生存率的分子标志物。
Abstract:
Objective: To investigate the HOTAIR expression in bladder cancer tissues and adjacent non-cancerous tissues and its potential relevance to clinicopathological variables and prognosis. Methods： HOTAIR RNA expression was determined by real-time quantitative polymerase chain reaction in 88 pairs of bladder cancer tissues and adjacent non-cancerous tissues. Kapaln-Meier analysis and COX proportional hazards regression models were used to investigate the correlation between HOTAIR expression and prognosis of bladder cancer patients. Results： This study showed that the expression level of HOTAIR in bladder cancer tissues was significantly higher than those in non-cancerous tissues. The results indicated that high expression of HOTAIR in bladder cancer was associated with advanced stage and high grade (P<0.05). Kapaln-Meier survival analysis suggested that patients with high HOTAIR expression was associated with poor overall survival(P<0.05). Multivariate analysis revealed that HOTAIR expression was an independent predictor of overall survival. Conclusions: HOTAIR might play a positive role in bladder cancer development and could serve as an biomarker for overall survival of bladder cancer.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 李宁（1984-），女，硕士在读，研究方向：流行病与卫生统计学；

通信作者：马骏，E-mail：majun@tmu.edu.cn。?
更新日期/Last Update: 2016-03-23