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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年02期

页码:

119-121

栏目:

基础医学

出版日期:

2016-03-20

文章信息/Info

Title:

Studies on chemical constituents fromＲhodiola wallichiana

文章编号:

1006-8147（2016）02-0119-03

作者:

?赵 娜¹; 赵国华²; 王仁久²; 曹明光²; 吴海波²; 柴雅晴¹; 唐生安¹; 段宏泉¹; 3

(1.天津医科大学药学院, 天津市临床药物关键技术重点实验室,天津 300070; 2.通化玉圣药业股份有限公司, 通化 134000;3.天津医科大学基础医学研究中心，天津 300070）

Author(s):

ZHAO Na¹;  ZHAO Guo-hua²;  WANG Ren-jiu²;  CAO Ming-guang²;  WU Hai-bo²; CHAI Ya-qing¹;  TANG Sheng-an¹;  DUAN Hong-quan¹

(1.?School of Pharmacy, Tianjin Medical University, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China; 2. Tonghua Yusheng Medicine Co., Ltd. Tonghua 134000, China;3.Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070,China)

关键词:

红景天属' target="_blank" rel="external">">红景天属; 大株红景天; 化学成分; 结构鉴定

Keywords:

Rhodiola;  Rhodiola wallichiana;  chemical constituents;  structure identification

分类号:

R9

DOI:

-

文献标志码:

A

摘要:

目的：对四川产大株红景天的化学成分进行分离鉴定。方法：采用硅胶柱色谱、凝胶柱色谱和HPLC制备色谱等方法分离纯化得到单体化合物，采用有机波谱方法鉴定化合物结构。结果：从大株红景天萃取物中分离得到10个化合物，分别鉴定为lotaustralin (1)、仲丁基葡萄糖苷 (2)、没食子酸 (3)、3-甲氧基没食子酸 (4)、没食子酸甲酯 (5)、3-羟基-4-甲氧基苯甲酸 (6)、苯甲醇 (7)、阿魏酸 (8)、对羟基肉桂酸 (9)、棉黄素-7-O-(3^?-O-β-D-葡萄糖基)-α-L-鼠李糖苷 (10)。结论：化合物2、6为首次从该属植物中分离得到，化合物1、5、8、9、10为首次从该种植物中分离得到。

Abstract:

Objective: To study the chemical constituents from Rhodiola wallichiana. Methods: Chemical constituents were isolated and purified by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. Results: Ten compounds (1-10) were isolated and their structures were identified by comparing their spectral data with literature values as follows: lotaustralin (1), sec-butyl-O-β-D-glycosidase (2), trihydroxybenzoic acid (3), 3-methoxy-trihydroxybenzoic acid (4), methyl gallate (5), 3-hydroxy-4-methoxy-benzoic acid (6), benzyl alcohol, (7)Ferulic Acid (8) ,4-Hydroxycinnamic acid (9), gossypetin-7-O-(3^?-O-β-D-glucosyl)-a-L-rhamnoside (10). Conclusion: Compound 2 and 6 are isolated from the genus Rhodiola for the first time, compound 1, 5, 8, 9 and 10 are isolated from this plant for the first time.

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参考文献/References:

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备注/Memo

备注/Memo:

作者简介 赵娜(1990-)女，硕士在读，研究方向：天然活性化学成分研究；通信作者：段宏泉，E-mail: duanhq@tijmu.edu.cn。

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