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[1]LI Yan-ping,CHAI Yan-fen.?连续血液滤过对严重脓毒症患者部分炎性指标及器官功能的影响 [J].天津医科大学学报,2015,21(06):491-493.
　LI Yan-ping,CHAI Yan-fen.?Effect of continuous hemofiltration on inflammatory mediators and organ function in severe sepsis[J].Journal of Tianjin Medical University,2015,21(06):491-493.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年06期
页码:
491-493
栏目:
临床医学
出版日期:
2015-11-20

文章信息/Info

Title:
?Effect of continuous hemofiltration on inflammatory mediators and organ function in severe sepsis
文章编号:
1006-8147（2015）06-0491-03
作者:
LI Yan-ping;  CHAI Yan-fen
(Department of Emergency , General Hospital , Tianjin Medical University, Tianjin 300052, China)
Author(s):
LI Yan-ping ; CHAI Yan-fen
(Department of Emergency , General Hospital , Tianjin Medical University, Tianjin 300052, China)
关键词:

">

严重脓毒症' target="_blank" rel="external">">严重脓毒症; 连续血液滤过; 炎症介质

?

Keywords:

line-height: 150%; " class="p0" align="left">severe sepsis ;  continuous hemofiltration ;  inflammatory mediators

分类号:
R631
DOI:
-
文献标志码:
A
摘要:
目的：分析连续血液滤过对严重脓毒症患者部分炎性指标的影响及意义，为临床疾病诊治提供一定理论依据。方法：回顾性分析经临床确诊为严重脓毒症患者共64例，所有患者均经连续性血液滤过治疗，比较治疗前后患者降钙素元（PCT）、C反应蛋白（CRP）、血沉（ESR）、D二聚体（Dimer）等炎性指标变化，通过常用肝肾功能指标判断患者重要器官功能改善情况。利用治疗前后氧合指数、APACHE-Ⅱ及多器官功能障碍综合征（MODS）评分判断治疗效果。结果：首次连续血液滤过治疗后，炎症指标PCT，CRP，ESR有明显下降（P<0.01），Dimer也有下降，但差异无统计学意义（P>0.05）。氧合指数明显改善、APACHE-Ⅱ及MODS评分明显改善，差异有统计学意义（P<0.05）。多次连续血液治疗后炎症指标PCT，CRP，ESR明显下降（P<0.01），Dimer也有下降，但差异无统计学意义（P>0.05）。肝肾功能指标改善明显（P<0.05），尿素氮也有降低（P>0.05）。APACHE-Ⅱ和氧合指数有了明显改善 （P<0.05），MODS评分较前相比无明显变化（P>0.05）。结论：连续血液滤过治疗严重脓毒症疗效较好，可以降低临床死亡率。
Abstract:

Objective: To observe the effect of continuous hemofiltration on inflammatory mediators in severe sepsis, and to provide a reference for the clinical diagnosis and treatment. Methods: Sixty-five patients with severe sepsis were treated by continuous hemofiltration. The content of PCT, CRP, ESR, Dimer, liver and renal function were compared before and after treatment, as well as oxygen index, APACHE-Ⅱand MODS score, to evaluate the improvement of the organ function and the effect of the treatment. Results: After the first treatment, PCT, CRP, ESR were significantly reduced (P<0.01) , and oxygenation index, APACHE -Ⅱ and MODS score were significantly improved (P<0.05). Dimer was also decreased, but no statistically significance was observed (P>0.05). After continuous blood treatment, PCT, CRP, ESR decreased significantly (P<0.01). Oxygenation index, APACHE -Ⅱscore, liver and renal function were significantly improved (P<0.05). Dimer, MODS score and blood urea nitrogen showed no statistically significant differences (P>0.05) between the first treatment and continuous blood treatment. Conclusion: Continuous hemofiltration in treatment of severe sepsis has marked curing effect and it can reduce clinical mortality.

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备注/Memo

备注/Memo:
作者简介 李研凭（1981-），男，住院医师，学士，研究方向：脓毒症; 通信作者：柴艳芬， E-mail:chaiyanfen2012@126.com。
更新日期/Last Update: 2015-11-27