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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年03期

页码:

189-192

栏目:

专题报道

出版日期:

2015-05-20

文章信息/Info

Title:

Prediction value of plasma cystatin C level in patients with acute coronary syndrome

文章编号:

1006-8147（2015）03-0189-04

作者:

李文军; 刘相丽; 孙丽丽; 李广平

(天津医科大学第二医院心脏科,天津300211)

Author(s):

LI Wen-jun; LIU Xiang-li;  SUN Li-li;  LI Guang-ping

(Department of Cardiology,The Second Hospital, Tianjin Medical University,Tianjin 300211,China)

关键词:

冠心病;  急性冠脉综合征;  血清胱抑素C; Gensini评分

Keywords:

coronary disease;  acute coronary syndrome;  cystatin C;  Gensini score

分类号:

R541.4

DOI:

-

文献标志码:

A

摘要:

目的：探讨血清胱抑素C（Cys C）水平在急性冠脉综合征（ACS）中的预测价值。方法： 选取132例行冠状动脉造影检查及治疗的ACS患者[不稳定型心绞痛（UA）组42例，非ST段抬高型心肌梗死（NSTEMI）组46例，ST段抬高型心肌梗死（STEMI）组44例]，同期选取41名冠状动脉造影检查阴性者作为对照组。收集并分析一般临床资料并检测Cys C，计算Gensini积分。结果: （1）各组间Cys C水平比较，差异有统计学意义( F = 52.732，P＜0.001)。（2）UA及NSTEMI患者Cys C水平与冠脉Gensini积分呈正相关。（3）多因素Logistic回归分析显示，高龄、吸烟史、Cys C水平升高，高密度脂蛋白水平降低是ACS的影响因素。结论: Cys C水平升高是ACS的危险因素,检测Cys C对冠脉病变狭窄程度的判断有指导意义。

Abstract:

Objective: To investigate the predictive capability of cystatin C（Cys C）among patients with acute coronary syndrome(ACS). Methods : A total of 132 subjects with ACS examined by coronary angiography(CAG) were consecutively enrolled and further divided into unstable angina（UA, n=42）, non-ST segment elevated myocardial infarction （NSTEMI, n=46）and ST segment elevated myocardial infarction（STEMI, n=44）. Forty-one subjects whose CAG results were negative were enrolled in case-control group. The clinical data were collected during hospitalization and Cys C was measured as well. All Gensini scores were evaluated. Results: (1) Statistical differences were found in cystatin C levels in each group ( F = 52.732，P＜0.001). (2) Positive correlation was detected between Cys C and Gensini score in UA and NSTEMI patients. (3) Logistic regression analysis showed that the factors affecting ACS were enhanced Cys C, smoking, diabetes and decreased high-density lipoprotein cholesterol. Conclusion：The level of serum Cys C is correlated with the degree of severity in ACS, and it is a risk factor for ACS.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 李文军（1988-），男，硕士在读，研究方向：心血管内科；

通信作者：刘相丽，E-mail：liuxl98@163.com。

常用功能

更新日期/Last Update: 2015-05-26