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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年02期

页码:

117-120

栏目:

临床医学

出版日期:

2015-03-20

文章信息/Info

Title:

Studies on the correlation between CETP TaqIB gene polymorphism and blood lipid and coronary heart disease

文章编号:

1006-8147（2015）02-0117-04

作者:

刘 瑞¹ ; 刘玉洁²; 何 乐²

(1.天津医科大学研究生院,天津 300070;2.天津市胸科医院心内科,天津 300222 )

Author(s):

LIU Rui¹; LIU Yu-jie²; HE Le²

(1.Graduate School，Tianjin Medical University，Tianjin 300070，China；2.Department of Cardiology，Chest Hospital of Tianjin，Tianjin 300222 ，China )

关键词:

冠心病; CETP; 血脂; 基因多态性

Keywords:

coronary heart disease;  CETP; lipid;  gene polymorphism

分类号:

R541.4

DOI:

-

文献标志码:

A

摘要:

 目的：探索CETP TaqIB基因多态性与脂代谢及冠心病 (CHD)发生的相关性。方法：选择天津市胸科医院住院病人430列，分为CHD组322例，对照组108例。入院后测定总胆固醇（CHO）、甘油三酯(TG)、高密度脂蛋白（HDL-c）、低密度脂蛋白（LDL-c）、载脂蛋白A1(Apo-A1)、载脂蛋白B（Apo-B）水平。采用PCR-RFLP方法测定研究对象CETP TaqIB基因型，分析CETP TaqIB基因多态性与血脂水平及冠心病发生的相关性。结果：（1）在CHD组，CETP TaqIB基因型B1B2、B2B2的HDL-C水平[（1.29±0.35） mmol/L、(1.16±0.36) mmol/L]较基因型B1B1[（1.09±0.22） mmol/L]相比有增高的趋势，但无显著的统计学差异（P> 0.05），CHO、TG、LDL-C、Apo-A1、Apo-B水平均无显著差异（P＞0.05）；对照组基因型间血脂水平无显著差异。（2）B1B1、B1B2、B2B2基因型频率在CHD组为35.1%、45.0%、19.9%，在对照组为37.0%、43.5%、19.5%；B1、B2等位基因频率在CHD组及对照组分别为57.6%、58.6%和42.4%、41.2%。两组CETP TaqIB基因型及等位基因分布无显著统计学差异（P>0.05）。结论：天津地区人群CETP TaqIB等位基因B2频率分布与国内其他地区人群相一致。尚不足以证明CETP TaqIB基因多态性与冠心病存在相关性。

Abstract:

Objective: To investigate the correlation between CETP TaqIB gene polymorphism and lipid metabolism and coronary heart disease (CHD). Methods：A total of 430 patients in Tianjin Chest Hospital were selected in the analysis. All the enrolled patients were divided into CHD group (n=322) and the control group (n=108). After admission total cholesterol (CHO) ,triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A (ApoA1), apolipoprotein B (ApoB) were tested PCR-RELP was executed to determine the genotypes of CETP TaqIB. Results：(1) In the CHD group, the CETP TaqIB genotype B1B2,B2B2 levels of HDL-C[(1.29±0.35) mmol/L, (1.16±0.36) mmol/L] were higher than genotype B1B1 level of HDL-C[(1.09±0.22) mmol/L],but no statistically significant difference (P>0.05) was found. The levels of CHO，TG，LDL-C，Apo-A1，Apo-B were statistically significant. No significant difference was found in the level of lipid in the control group genotype. (2) The frequencies of genotype B1B1, B1B2 and B2B2 were 35.1%, 45.0%, 19.9% in CHD group, and 37.0%, 43.5%, 19.5% in the control group. The frequencies of B1, B2 allele were 57.6%, 58.6% in CHD group, and 42.4%, 41.2% in the control group. No statistical significance in genotype and allele frequency was found between CHD group and the control group (P>0.05). Conclusion: CETP TaqIB gene B2People in Tianjin area is consistent with other parts of the country. The existence of correlation between CETP TaqIB gene polymorphism and coronary heart disease needs further evidence.

参考文献/References:

[1]刘静，赵冬，秦兰萍，等. 低密度脂蛋白胆固醇与心血管病发病关系的前瞻性研究[J]. 中华心血管病杂志, 2001,29(9):561
[2]de Simone G, Devereux R B, Chinali M, et al. Resnick HE,et al.metabolic syndrome and left ventricular hypertrophy in the prediction of cardiovasular events:the strong HeartStudy[J]. Nutr Metab Cardiovasc Dis, 2009,19(7):98
[3]He J, Gu D, Wu X, et al. Major causes of death among men and women in China[J]. N Engl J Med, 2005,353(11):1124
[4]Badimon L, Vilahur G, Padro T. Nutraceuticals and atherosclerosis: human trials[J]. Cardiovasc Ther, 2010,28(4):202
[5]Mitchell L E, Long J, Garbarini J, et al. Variants of folate metabolism genes and risk of Left-Sided cardiac defects[J]. Birth Defects Res A Clin Mol Teratol, 2010,88(1):48
[6]Musunuru K, Lettre G, Young T, et al. Candidate gene association resource (CARe) design, methods, and proof of concept[J]. Circ Cardiovasc Genet, 2010,3(3):U94
[7]Shinkai H cholesteryl ester transfer-protein modulator and inhibitors and theirpotential for the treatment of cardiovascular diseases[J]. Vase Health Risk Manag, 2012,8 :323
[8]Thompson J F. High-density genotyping and functional SNP localization in the CETP gene[J]. J lipid Res，2007,48(2):434
[9]Peacock J M, Arnett D K, Atwood L D, et al. Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol - The NHLBI family heart study[J]. Arterioscler Thromb Vasc Biol, 2001,21(11):1823
[10]Eren E, Yilmaz N. Aydin O. High density lipoprotein and ifs dysfunction[J]. Open Biochem J, 2012,6:78
[11]Ordovas J M, Cupples L A, Corella D, et al. Association of cholesteryl ester transfer protein TaqlB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk:the Framingham study[J]. Arterioscler Thromb Vase Biol, 2000,20(5):1323
[12]Borggreve S E, ?Hillege HL, Wolffenbuttel BH, et al. An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study[J]. J Clin Endocrinol Metab, 2006,91(9):3382
[13]王伟，周新，刘芳，等. 胆固醇酯转运蛋白基因TaqIB多态性、D442G突变与冠心病的相关性研究[J]. 中华心血管病杂志, 2004,32(11):24
[14]鄢盛恺，朱燕林，程澍，等. 汉族人胆固醇酯转运蛋白基因TaqIB、MspI多态性与冠心病的关系研究[J]. 中华检验医学杂志, 2004,27(10):47
[15]陈筱潮，徐明彤，韩春丽，等. 中国人胆固醇酯转运蛋白TaqIB基因多态性与冠心病关系的Meta分析[J]. 中国动脉硬化杂志, 2006,14(11):997
[16]周代锋，云美玲，蔡望伟，等. 胆固醇酯转运蛋白基因6个多态位点与冠心病的关系[J]. 临床心血管病杂志, 2010,26(2):116

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备注/Memo

备注/Memo:

基金项 天津市卫生局科技基金资助项目（ 2013KY34）

作者简介 刘瑞（1989-），女，硕士在读，研究方向：心血管疾病；

通信作者：刘玉洁， E-mail yujieliu2011@126.com。

 

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更新日期/Last Update: 2015-03-24