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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

30卷

期数:

2024年01期

页码:

1-5

栏目:

肝脏疾病专题

出版日期:

2024-01-01

文章信息/Info

Title:

Effect of Yinchen Wuling Powder on T cell subsets in patients with obstructive jaundice after biliary tract surgery

文章编号:

1006-8147(2024)01-0001-05

作者:

韩树旺;  尚海涛;  张德林;  郝成飞;  刘军舰

（天津市中西医结合医院肝胆胰外科，天津300100）

Author(s):

HAN Shuwang; SHANG Haitao; ZHANG Delin; HAO Chengfei; LIU Junjian

（Department of Hepatobiliary and Pancreatic Surgery，Tianjin Hospital of Integrated Traditional Chinese and Western Medicine，Tianjin 300100，China）

关键词:

阻塞性黄疸; 胆总管结石; 茵陈五苓散; T淋巴细胞亚群; 细胞因子

Keywords:

-

分类号:

R575.7

DOI:

10.20135/j.issn.1006-8147.2024.01.0001

文献标志码:

A

摘要:

目的：探讨茵陈五苓散对胆道结石引起的阻塞性黄疸患者胆道术后T细胞亚群的变化。方法：选取2021年6月至2022年3月就诊于天津市中西医结合医院肝胆胰外科诊断为良性阻塞性黄疸患者，共76例，患者随机分为对照组和观察组，在胆道术后对照组给予西医常规治疗，观察组在常规治疗基础上加用茵陈五苓散方（颗粒剂），两组治疗周期均为7 d。观察两组治疗前后外周静脉血T淋巴细胞亚群水平和细胞因子[白细胞介素（IL）-10、转化生长因子（TGF）-β1）]浓度变化。结果：两组患者在胆道术后治疗5 d、7 d，CD3+ T淋巴细胞、CD4+ T淋巴细胞、CD4+/CD8+比值均较术前1 d增加（均P<0.05），CD4+CD25+ Treg细胞较术前1 d减少，差异有统计学意义（均P<0.05）；术后5 d、7 d两组组间比较CD3+、CD4+ T淋巴细胞、CD4+/CD8+比值变化，观察组较对照组升高明显，差异有统计学意义（均P<0.05），两组组内、组间CD8+ T淋巴细胞比较均无统计学差异（均P>0.05）。与对照组相比，观察组术后5 d、7 d，IL-10、TGF-β1浓度降低（均P<0.05）。结论：胆道术后早期联合茵陈五苓散对机体细胞免疫功能恢复有重要的辅助作用，具有一定的免疫调节作用。

Abstract:

Objective： To investigate the changes of T cell subsets in patients with obstructive jaundice caused by bile duct stones after biliary tract surgery with Yinchen Wuling Powder. Methods： A total of 76 patients diagnosed with benign obstructive jaundice were enrolled in the Department of Hepatobiliary and Pancreatic Surgery of Tianjin Hospital of Integrated Traditional Chinese and Western Medicine from June 2021 to March 2022. They were randomly divided into control group and observation group. The control group received conventional western medicine treatment after biliary tract surgery, and the observation group received conventional treatment, on the basis， add Yinchen Wuling Powder （granules）. The treatment period for both groups was 7 days. The levels of T lymphocyte subsets and the concentration of cytokines [interleukin （IL）-10， transforming growth factor （TGF）-β1] in peripheral venous blood of the two groups of patients before and after treatment were observed. Results： The two groups of patients were treated for 5 days and 7 days after biliary tract surgery. CD3+ T lymphocytes, CD4+ T lymphocytes, and CD4+/CD8+ ratios were increased compared with the 1st day before operation（all P<0.05）. CD4+CD25+ Treg cells decreased compared to the 1st day before operation， with statistically significant difference（all P<0.05）. The changes of CD3+ T lymphocytes， CD4+ T lymphocytes， and CD4+/CD8+ ratio were compared between the two groups at 5 d and 7 d after surgery， and the increase in the observation group was significantly higher than that in the control group， the difference was statistically significant（all P<0.05）， while the comparison of CD8+ T lymphocytes within or between the two groups was not statistically significant（all P>0.05）. The concentration of IL-10 and TGF-β1 in the observation group was significantly lower than that in the control group at 5 d and 7 d after surgery（all P<0.05）. Conclusion： The

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相似文献/References:

[1]姜海波,王俊梅,刘贯华.ERCP治疗胆总管结石合并肝硬化的效果分析[J].天津医科大学学报,2018,24(02):162.
　JIANG Hai-bo,WANG Jun-mei,LIU Guan-hua.Effect of ERCP in the treatment of common bile duct stones complicated with cirrhosis[J].Journal of Tianjin Medical University,2018,24(01):162.
[2]陈帅,刘军舰,尚海涛,等.基于网络药理学、分子对接及实验探讨茵陈蒿汤调节阻塞性黄疸氧化应激的作用机制[J].天津医科大学学报,2021,27(06):595.
　CHEN Shuai,LIU Jun-jian,SHANG Hai-tao,et al.Based on network pharmacology，molecular docking，and experiments to explore the mechanism of Yinchenhao Decoction in regulating oxidative stress of obstructive jaundice[J].Journal of Tianjin Medical University,2021,27(01):595.
[3]孙一萌,刘浩,刘军舰,等.茵陈蒿汤对阻塞性黄疸大鼠肝细胞ATF6/GRP78/CHOP凋亡信号通路的影响[J].天津医科大学学报,2023,29(03):252.
　SUN Yi-meng,LIU Hao,LIU Jun-jian,et al.Influence of Yinchenhao decoction on the expression of ATF6/GRP78/CHOP apoptotic signaling pathway in hepatocyte of rats with obstructive jaundice[J].Journal of Tianjin Medical University,2023,29(01):252.

备注/Memo

备注/Memo:

基金项目 天津市教委科研计划项目（2022KJ271）；天津市中医药重点领域科研项目（2019003）；天津市卫健委中医中西医结合科研项目（2021042）
作者简介 韩树旺（1988-），男，医师，硕士，研究方向：中西医肝胆胰脾外科临床与基础；通信作者：刘军舰，E-mail：nkyyljj@outlook.com。

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更新日期/Last Update: 2024-01-01