|本期目录/Table of Contents|

[1]呼学敏,王雨杭,杜雪.孟德尔随机化法探究端粒长度与多囊卵巢综合征的关联[J].天津医科大学学报,2025,31(03):257-261.[doi:10.20135/j.issn.1006-8147.2025.03.0257]
　HU Xuemin,WANG Yuhang,DU Xue.Study on the relationship between telomere length and polycystic ovary syndrome by Mendel randomization method[J].Journal of Tianjin Medical University,2025,31(03):257-261.[doi:10.20135/j.issn.1006-8147.2025.03.0257]
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孟德尔随机化法探究端粒长度与多囊卵巢综合征的关联(PDF)

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
31卷
期数:
2025年03期
页码:
257-261
栏目:
基础医学
出版日期:
2025-05-20

文章信息/Info

Title:
Study on the relationship between telomere length and polycystic ovary syndrome by Mendel randomization method
文章编号:
1006-8147(2025)03-0257-05
作者:
呼学敏1; 王雨杭2; 杜雪1
（1.天津市人民医院，南开大学第一附属医院妇科，天津 300121；2.天津医科大学研究生院，天津 300070）
Author(s):
HU Xuemin1; WANG Yuhang2; DU Xue1
（1.Department of Gynecology，Tianjin Union Medical Center，The First Affiliated Hospital of Nankai University，Tianjin 300121，China；2.Graduate School，Tianjin Medical University，Tianjin 300070，China）
关键词:
多囊卵巢综合征; 端粒长度; 孟德尔随机化
Keywords:
polycystic ovary syndrome; telomere length; Mendelian randomization
分类号:
R71
DOI:
10.20135/j.issn.1006-8147.2025.03.0257
文献标志码:
A
摘要:
目的：采用孟德尔随机化方法（MR）分析白细胞端粒长度（LTL）和多囊卵巢综合征（PCOS）间是否存在因果关系。方法：从全基因组关联研究数据中筛选出与 LTL 强相关的单核苷酸多样性（SNPs）作为工具变量，采用逆方差加权法（IVW）作为主要分析方法，MR-Egger 法、加权中位数法、简单模型和加权模型作为辅助分析方法，以评价 LTL 和 PCOS 之间的因果关系，同时采用 MR-Egger 截距测试、Cochran Q 检验、逐一排除法评估工具变量的水平多效性和异质性。结果：共纳入 23 个 SNPs，IVW 结果显示，LTL 缩短是 PCOS 的危险因素（OR=0.585，95%CI：0.374~0.986，P=0.044），MR-Egger 法、加权中位数法、简单模型和加权模型 4 种辅助分析方法的结果与 IVW 方法的结果一致，MR-Egger 截距测试、Cochran Q 检验以及逐一排除法的结果均显示了结果的稳定性。结论：LTL 缩短是 PCOS 的潜在危险因素。
Abstract:
Objective： To analyze the causal relationship between leukocyte telomere length （LTL） and polycystic ovary syndrome （PCOS） using Mendelian randomization （MR）. Methods：Single nucleotide polymorphisms （SNPs） strongly associated with LTL were screened as instrumental variables from genome-wide association study data. Inverse variance weighted （IVW） method was used as the main analysis method，MR-Egger method，weighted median method，simple model and weighted model were used as auxiliary analysis methods to evaluate the causal relationship between LTL and PCOS. MR-Egger intercept test，Cochran Q test and leave one out method，were used to evaluate the level pleiotropy and heterogeneity of instrumental variables. Results：A total of 23 SNPs were included. IVW results showed that shortened LTL was a risk factor for PCOS （OR=0.585，95%CI：0.374-0.986，P=0.044）. The results of four auxiliary analysis methods，MR-Egger method，weighted median method，simple model，and weighted model，were consistent with the results of IVW method. The stability of the results was demonstrated by MR-Egger intercept test，Cochran Q test，and leave one out method. Conclusion：Shortened LTL is a potential risk factor for PCOS.

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备注/Memo

备注/Memo:
基金项目: 天津市人民医院院级课题（2023YJ006）
作者简介: 呼学敏（1995-），女，医师，硕士，研究方向：妇科内分泌；
通信作者：杜雪，E-mail：lanlandetommao@163.com。
更新日期/Last Update: 2025-06-01