[1] MCGLYNN K A,PETRICK J L,ELSERAG H B. Epidemiology of hepatocellular carcinoma[J]. Hepatology,2020,73:10.
[2] FORNER A,REIG M,BRUIX J. Hepatocellular carcinoma[J]. Lancet,2018,391(10127):1301-1314.
[3] 黄成,朱小东,沈英皓,等.免疫检查点抑制剂在肝细胞癌治疗中的特征[J].中华肝胆外科杂志,2020,26(1):75-80.
[4] LEE D W,HAN S W,BAE J M,et al. Tumor mutation burden and prognosis in patients with colorectal cancer treated with adjuvant fluoropyrimidine and oxaliplatin[J]. Clin Cancer Res,2019,25(20):6141-6147.
[5] MAYAKONDA A,LIN D C,ASSENOV Y,et al. Maftools: efficient and comprehensive analysis of somatic variants in cancer[J]. Genome Res,2018,28(11):1747-1756.
[6] CAMP R L,DOLLED M,RIMM D L. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization[J]. Clin Cancer Res,2004,10(21):7252-7259.
[7] ROBINSON M D,MCCARTHY D J,SMYTH G K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data[J]. Bioinformatics,2010,26(1):139-140.
[8] YANG J D,HEIMBACH J K. New advances in the diagnosis and management of hepatocellular carcinoma[J]. BMJ,2020,371:m3544.
[9] GOODMAN A M,KATO S,BAZHENOVA L,et al. Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers[J]. Mol Cancer Ther,2017,16(11):2598-2608.
[10] HEEKE S,BENZAQUEN J,MIRA E,et al. In-house implementation of tumor mutational burden testing to predict durable clinical benefit in non-small cell lung cancer and melanoma patients[J]. Cancers (Basel),2019,11(9):1271.
[11] LU L,FU X,LI Z,et al. Platelet-derived growth factor receptor alpha (PDGFRα) is overexpressed in NK/T-cell lymphoma and mediates cell survival[J]. Biochem Biophys Res Commun,2018,504(2):525-531.
[12] KRZYWINSKA E,KANTATI C,KERDILES Y,et al. Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis[J]. Nat Commun,2017,8(1):1597.
[13] HODGE G,BARNAWI J,JURISEVIC C,et al. Lung cancer is associated with decreased expression of perforin,granzyme B and interferon (IFN)-γ by infiltrating lung tissue T cells,natural killer (NK)T-like and NK cells[J]. Clin Exp Immunol,2014,178(1):79-85.
[14] WU Y,LI J,KABOLI P,et al. Natural killer cells as a double-edged sword in cancer immunotherapy:a comprehensive review from cytokine therapy to adoptive cell immunotherapy[J]. Pharmacol Res,2020,155:104691.
[15] MOON J S,KIM H E,KOH E,et al. Krüppel-like factor 4(KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase(PFKP) in breast cancer[J]. J Biol Chem,2011, 286(27):23808-23816.
[16] WANG J,ZHANG P,ZHONG J,et al. The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma[J]. Oncotarget,2016,7(19):27142-27157.
[17] LEE S Y,JIN C C,CHOI J E,et al. Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer[J]. Sci Rep,2016,6:35603.
[18] PARK Y Y,KIM S B,HAN H D,et al. T at-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520[J]. Hepatology,2013,58(1):182-191.
[19] STORCH J,THUMSER A E. Tissue-specific functions in the fatty acid-binding protein family[J]. J Biol Chem,2010,285(43):32679-32683.
[20] OHATA T,YOKOO H,KAMIYAMA T,et al. Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition[J]. Cancer Med,2017,6(5):1049-1061.
[21] MONNIER J,SAMSON M. Prokineticins in angiogenesis and cancer[J]. Cancer Lett,2010,296(2):144-149.
[22] 黄秀红,谢肖立,姜慧卿.微RNA风险评分模型预测肝细胞癌预后的价值分析[J].临床肝胆病杂志,2021,37(5):1110-1115.
[23] 杨双燕,任红,李传飞,等.基于生物信息学分析筛选肝细胞癌中的核心基因:细胞周期蛋白B2可作为肝癌潜在的诊疗和预后生物标志物[J].中华肝脏病杂志,2020,28(9):773-783.
[1]周冷潇,韩 涛.慢性乙型病毒性肝炎肝硬化发生肝细胞癌的危险因素分析[J].天津医科大学学报,2017,23(03):214.
ZHOU Leng-xiao,HAN Tao.Risk factors of hepatocellular carcinoma in patients with hepatitis B virus-related liver cirrhosis[J].Journal of Tianjin Medical University,2017,23(01):214.
[2]周冷潇,韩 涛,刘 芳.无创肝纤维化指标结合甲胎蛋白对乙型肝炎相关肝细胞癌的评估[J].天津医科大学学报,2017,23(05):415.
ZHOU Leng-xiao,HAN Tao,LIU Fang.Assessment of non-invasive fibrosis indexes with alpha-fetoprotein?for? hepatitis B virus-related hepatocellular carcinoma[J].Journal of Tianjin Medical University,2017,23(01):415.
[3]张自立,石文霞,李 霖,等.肝癌血清中miRNA-183的表达及临床意义[J].天津医科大学学报,2017,23(06):519.
ZHANG Zi-li,?SHI Wen-xia,LI Lin,et al.Expression and significance of serum microRNA-183 in hepatocellular carcinoma[J].Journal of Tianjin Medical University,2017,23(01):519.
[4]侯振宇,孔银龙,孙 林,等.92例晚期肝细胞癌患者肝切除预后及危险因素分析[J].天津医科大学学报,2018,24(05):425.
HOU Zhen-yu,KONG Yin-long,SUN Lin,et al.Prognosis and survival risk factors for 92 advanced hepatocellular carcinoma patients after hepatectomy[J].Journal of Tianjin Medical University,2018,24(01):425.
[5]胡 源,许戈良,荚卫东,等.C1QL1蛋白在原发性肝细胞癌中的表达及其临床意义[J].天津医科大学学报,2019,25(04):329.
HU Yuan,XU Ge-liang,JIA Wei-dong,et al.Expressions of C1QL1 protein inprimaryhepatocellular carcinoma and its clinical significance[J].Journal of Tianjin Medical University,2019,25(01):329.
[6]陈赛鹏,王嘉南,王 林,等.基于TCGA数据库分析甲基化促进精原细胞瘤进程的作用机制[J].天津医科大学学报,2019,25(05):463.
CHEN Sai-peng,WANG Jia-nan,WANG Lin,et al.Integrated analysis of the mechanism of methylation promoting the progress of seminomas based on the TCGA database[J].Journal of Tianjin Medical University,2019,25(01):463.
[7]张萃萃,邓为民.基因表达谱分析肝细胞癌的特征基因[J].天津医科大学学报,2020,26(06):514.
ZHANG Cui-cui,DENG Wei-min.Gene expression profiling reveals important characteristic genes in hepatocellular carcinoma[J].Journal of Tianjin Medical University,2020,26(01):514.
[8]张杨,游阿彬,齐寒,等.负载化疗药物的外泌体对肝癌的靶向治疗研究[J].天津医科大学学报,2021,27(03):229.
ZHANG Yang,YOU A-bin,QI Han,et al.Tumor-derived exosomes mediate targeted therapy in hepatocellular carcinoma mice[J].Journal of Tianjin Medical University,2021,27(01):229.
[9]高周勇,张文成,王广舜.基于TCGA数据库分析GTSE1基因在肺腺癌中的表达及意义[J].天津医科大学学报,2021,27(03):274.
GAO Zhou-yong,ZHANG Wen-cheng,WANG Guang-shun.Expression and significance of GTSE1 gene in lung adenocarcinoma based on TCGA database[J].Journal of Tianjin Medical University,2021,27(01):274.
[10]赵耕,张盈莹,卓永,等.藏区慢性乙型肝炎患者使用PAGE-B模型对肝细胞癌的风险预测研究[J].天津医科大学学报,2022,28(06):654.
ZHAO Geng,ZHANG Ying-ying,ZHUO Yong,et al.Risk prediction of hepatocellular carcinoma using the PAGE-B model in Tibetan patients with chronic hepatitis B[J].Journal of Tianjin Medical University,2022,28(01):654.