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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

27卷

期数:

2021年04期

页码:

334-337

栏目:

心血管疾病专题

出版日期:

2021-07-20

文章信息/Info

Title:

Relationship between expression of h-FABP and PAC-1 and coronary artery damage in children with KD in acute phase

文章编号:

1006－8147（2021）04-0334-04

作者:

贾丽娟; 吕爱婷; 冯迎军; 王芳洁; 孙琪青

（郑州大学附属儿童医院心血管内科，河南省儿童医院心血管内科，郑州儿童医院心血管内科，郑州450000）

Author(s):

JIA Li-juan; Lyu Ai-ting; FENG Ying-jun; WANG Fang-jie; Sun Qi-qing

（Department of Cardiovascular Internal Medicine，Children′s Hospital Affiliated to Zhengzhou University， Henan Children′s Hospital， Zhengzhou Children′s Hospital，Zhengzhou 450000，China）

关键词:

川崎病; 心型脂肪酸结合蛋白; 血小板膜糖蛋白Ⅱb/Ⅲa纤维蛋白原受体; 冠状动脉受损; 心功能

Keywords:

Kawasaki disease; heart-type fatty acid binding protein; platelet membrane glycoprotein Ⅱb/Ⅲa fibrinogen receptor; coronary artery damage; cardiac function

分类号:

R72

DOI:

-

文献标志码:

A

摘要:

目的：探讨川崎病（KD）患儿急性期心型脂肪酸结合蛋白（h-FABP）、血小板膜糖蛋白Ⅱb/Ⅲa纤维蛋白原受体（PAC-1）表达与冠状动脉受损的关系。方法：选取2017年1月—2019年8月治疗的KD患儿101例（观察组），其中有冠状动脉损伤者48例，同时选取健康儿童60名作为对照组，采用酶联免疫吸附法检测血清h-FABP水平，采用流式细胞仪检测PAC-1表达。结果：观察组血清h-FABP、PAC-1表达水平分别为（19.94±4.03）ng/mL和（6.44±1.12）%，明显高于对照组（均P＜0.05）；观察组有冠状动脉损伤患儿血清h-FABP、PAC-1表达水平分别为（20.12±3.32）ng/mL和（6.94±1.06）%，明显高于无冠状动脉损伤患儿（均P＜0.05）；观察组重度冠状动脉损伤患儿血清h-FABP、PAC-1表达水平分别为（18.22±2.19） ng/mL和（6.22±1.00）%，明显高于轻中度患儿（均P＜0.05）；观察组血清h-FABP、PAC-1与D-D呈正相关性（r=0.433和0.501，均P＜0.05）；血清h-FABP、PAC-1诊断有无冠状动脉损伤的ROC曲线下面积分别为0.801和0.779（P＜0.05），截断值分别为18.50 ng/mL和6.10%，灵敏性分别为80.50%和77.80%，特异性分别为78.00%和70.00%。结论：KD患儿急性期h-FABP、PAC-1表达升高，与患儿冠状动脉受损有关。

Abstract:

Objective: To investigate the relationship between the expression of heart-type fatty acid binding protein（h-FABP），platelet membrane glycoprotein Ⅱb/Ⅲ a fibrinogen receptor （PAC-1） and coronary artery damage and cardiac function in children with Kawasaki disease （KD）. Methods: A total of 101 children with KD （observation group） treated from January 2017 to August 2019 were selected，including 48 cases with coronary artery injury，and 60 healthy children were selected as control group，the serum h-FABP level was detected by ELISA，PAC-1 expression was detected by flow cytometry. Results: The expression levels of serum h-FABP and PAC-1 in the observation group were （19.94±4.03） ng/mL and（6.44 ±1.12）%，which were significantly higher than those in the control group（all P<0.05）.The expression levels of serum h-FABP and PAC-1 in the observation group were （20.12±3.32） ng/mL and （6.94±1.06）%，which were significantly higher than those in the non-coronary injury group（all P<0.05）. The levels of serum H-FABP and PAC-1 inchildren with severe coronary injury of the observation group were（18.22 ± 2.19） ng/mL and（6.22 ± 1.00）%，which were significantly higher than those in the mild to moderate group （all P < 0.05）；in the observation group，serum h-FABP and PAC-1 were positively correlated with D-D（r=0.433 and 0.501，all P<0.05）；the area under the ROC curve of serum h-FABP and PAC-1 for diagnosis of coronary artery injury was 0.801 and 0.779（all P <0.05），the cutoff values were 18.50 ng/mL and 6.10%，the sensitivity was 80.50% and 77.80%，and the specificity was 78.00% and 70.00%，respectively.Conclusion:The expression of h-FABP and PAC-1 increase in KD children in acute phase，which are related to the impairment of coronary artery.

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[1]王晓晓,周宇辉,王 倩,等.氨基末端脑钠肽前体水平对丙种球蛋白无反应性川崎病的预测价值[J].天津医科大学学报,2016,22(06):502.
　WANG Xiao-xiao,ZHOU Yu-hui,WANG Qian,et al.Predictive value of plasma brain natriuretic peptide in IVIG-resistant Kawasaki disease[J].Journal of Tianjin Medical University,2016,22(04):502.
[2]王 茜,周宇辉,王雨婷,等.川崎病并发冠状动脉损害危险因素的探讨[J].天津医科大学学报,2020,26(01):56.
　WANG Xi,ZHOU Yu-hui,WANG Yu-ting,et al.Risk factors of complicated coronary artery lesion in Kawasaki disease[J].Journal of Tianjin Medical University,2020,26(04):56.
[3]韩飞 综述,刘力 审校.血清Ｎ末端Ｂ型利钠肽在识别川崎病冠状动脉损伤中的研究进展[J].天津医科大学学报,2021,27(02):208.

备注/Memo

备注/Memo:

基金项目： 河南省医学科技攻关计划（2018020695）
作者简介：贾丽娟（1982-），女，副主任医师，硕士， 研究方向：儿科心血管疾病； E-mail:jia_lijuan313@163.com。

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更新日期/Last Update: 2021-07-25