|本期目录/Table of Contents|

[1]王晨旭 综述,于泳浩,谢克亮,等.AMPA受体在阿尔兹海默症中的研究进展[J].天津医科大学学报,2020,26(03):292-295.
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AMPA受体在阿尔兹海默症中的研究进展(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年03期
页码:
292-295
栏目:
综述
出版日期:
2020-06-10

文章信息/Info

Title:
-
文章编号:
1006-8147(2020)03-0292-04
作者:
王晨旭 综述; 于泳浩; 谢克亮; 王国林 审校
（天津医科大学总医院麻醉科，天津 300052 ）
Author(s):
-
关键词:
AMPA受体; 阿尔茨海默病; 淀粉样蛋白; τ神经纤维缠结
Keywords:
-
分类号:
R742.8+2
DOI:
-
文献标志码:
A
摘要:
AMPA受体（AMPARs）是调节突触强度和可塑性的关键受体，其动态运输、活性和亚基组成受到严格的调控。神经退行性病变是困扰老龄化人口的主要问题之一，AMPARs的转运失调可能与大多数神经退行性疾病有关。了解AMPARs在生理和病理性认知衰退期间的调控机制，将有助于开发有效的方法来治疗神经退行性疾病。通过概述AMPARs转运所涉及的分子机制，重点介绍目前已知的与衰老和疾病相关的变化过程。以阿尔茨海默病（AD）作为病理性老化的研究例子进行讨论，阐述τ神经纤维缠结（NFT）和淀粉样-β斑块（Aβ）对AMPARs的功能破坏。
Abstract:
-

参考文献/References:

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备注/Memo

备注/Memo:
基金项目 天津医科大学总医院青年孵育基金（ZYYFY2015024）；国家自然科学基金资助项目（81772043）；天津市自然科学基金面上项目（17JCYBJC24800）
作者简介 王晨旭（1986-），女，主治医师，硕士在读，研究方向：麻醉药的器官保护与损伤；通信作者：王国林，E-mail：wang_guolin@hotmail.com。
更新日期/Last Update: 2020-06-13