«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年04期

页码:

363-365

栏目:

临床医学

出版日期:

2019-07-20

文章信息/Info

Title:

The effect of C5a on systemic lupus erythematosus and its damage of nervous system

文章编号:

1006-8147(2019)04-0363-03

作者:

朱桂晋 ; 赵 冕; 周 蕾

（天津医科大学总医院风湿免疫科, 天津300052）

Author(s):

ZHU Gui-jin;  ZHAO Mian;  ZHOU Lei

(Department of Rheumatology and Immunology, General Hospital, Tianjin Medical University, Tianjin 300052, China)

关键词:

红斑狼疮; 系统性; 神经精神狼疮; C5a; 补体

Keywords:

lupus erythematosus; systemic;  neuropsychiatric lupus;  C5a;  complement

分类号:

R593.24+1

DOI:

-

文献标志码:

A

摘要:

目的：检测系统性红斑狼疮（SLE）患者血清和脑脊液中补体片段C5a水平，探讨C5a与SLE及其神经系统损害的关系及其临床意义。方法: 选取天津医科大学总医院风湿免疫科住院的SLE患者23例，收集其外周血及脑脊液，根据有无神经精神受累分为神经精神狼疮（NPSLE）组和非NPSLE组，16例NPSLE患者中8例进行了治疗前后配对比较；同时收集17例健康对照外周血。采用ELISA方法测定血清及脑脊液中C5a水平，比较上述各组间血清及脑脊液中C5a差异，并采用Pearson相关分析NPSLE组血清C5a与脑脊液C5a的相关性。结果: SLE患者血清C5a水平明显高于健康对照，NPSLE患者的血清及脑脊液C5a水平明显高于非NPSLE患者，且NPSLE患者治疗后血清及脑脊液C5a水平明显降低，差异均具有统计学意义（P<0.05）；NPSLE患者血清与脑脊液中的C5a水平呈正相关关系（r=0.703，P=0.002）。结论：监测血清及脑脊液中补体片段C5a的水平有助于NPSLE的病情评估及疗效判断。

Abstract:

Objective: To detect the level of complement fragment C5a in serum and cerebrospinal fluid(CSF) in patients with systemic lupus erythematosus(SLE), and to explore the effect of C5a and SLE on damage of nervous system. Methods: Twenty-three patients with SLE admitted to the Department of Rheumatology and Immunology of Tianjin Medical University General Hospital were enrolled. Peripheral blood and CSF were collected. The neuropsychiatric lupus (NPSLE) group and non-NPSLE group were included according to the presence or absence of neuropsychiatric involvement. Eight patients in the NPSLE group were compared before and after treatment; Peripheral blood from 17 healthy controls was also collected. The levels of C5a in serum and CSF were determined by ELISA. The differences in C5a in serum and CSF between the above groups were compared, and the correlation between serum C5a and CSF C5a in NPSLE group was analyzed by Pearson correlation. Results: Serum C5a levels in SLE patients were significantly higher than those in healthy controls,the serum and CSF C5a levels in NPSLE patients were significantly higher than those in non-NPSLE patients, and the serum and CSF C5a levels were significantly lower after treatment (P<0.05); serum C5a levels in NPSLE patients were positively correlated with CSF C5a levels(r=0.703, P=0.002). Conclusion: Monitoring the level of complement fragment C5a in serum and CSF may contribute to the evaluation and efficacy of NPSLE.

参考文献/References:

[1] 杨娉婷, 徐泳, 王家宁,等. 系统性红斑狼疮并发神经精神性狼疮[J]. 中国实用内科杂志, 2015, 35(10): 828
[2] Magro-Checa C, Schaarenburg R A, Beaart H J, et al. Complement levels and anti-C1q autoantibodies in patients with neuropsychiatric systemic lupus erythematosus[J]. Lupus, 2016, 25(8): 878
[3] 王会会, 陈国江, 黎燕,等. 补体C5a、C5a受体及其拮抗剂的研究进展[J]. 国际药学研究杂志, 2010, 37(3): 181
[4] Monk P N, Scola A M, Madala P, et al. Function, structure and therapeutic potential of complement C5a receptors[J]. Brit J Pharmacol, 2010, 152(4): 429
[5] Sakuma Y, Nagai T, Yoshio T, et al. Differential activation mechanisms of serum C5a in lupus nephritis and neuropsychiatric systemic lupus erythematosus[J]. Japan J Rheumatol, 2016, 27(2): 292
[6] Mahajan S D, Parikh N U, Woodruff T M, et al. C5a alters blood–brain barrier integrity in a human in vitro model of systemic lupus erythematosus[J]. Immunology, 2015, 146（1）:130
[7] Hochberg M C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthr itis Rheum, 1997, 40(9): 1725
[8] The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes[J]. Arthritis Rheum, 1999, 42(4): 599
[9] Lang M H, Sarma J V, Zetoune F S, et al. Generation of C5a in the absence of C3: a new complement activation pathway[J]. Mol Immunol, 2006, 44(1): 235
[10] Short A, Wong A K, Finch A M, et al. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat[J]. Br J Pharmacol, 2010, 126(3): 551
[11] Jacob A, Hack B, Chen P, et al. C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-κB[J]. J Neurochem, 2011, 119(5): 1041
[12] Jacob A, Hack B, Bai T, et al. Inhibition of C5a receptor alleviates experimental CNS lupus[J]. J Neuroimmunol, 2010, 221(1): 46

相似文献/References:

[1]陈 宪,周 蕾,庞 杰,等.血尿酸与系统性红斑狼疮患者肾损害的关系[J].天津医科大学学报,2014,20(01):42.
　CHEN Xian,ZHOU Lei,PANG Jie,et al.Association of serum uric acid with lupus nephritis in systemic lupus erythematosus patients[J].Journal of Tianjin Medical University,2014,20(04):42.
[2]李晓洁,周 蕾,陈 宪,等.超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系[J].天津医科大学学报,2015,21(03):63.
　LI Xiao-jie,ZHOU Lei,CHEN Xian,et al.Relationship between high-sensitivity C-reactive and complement 3 and disease activity in systemic lupus erythematosus[J].Journal of Tianjin Medical University,2015,21(04):63.
[3]李晓洁,周 蕾,陈 宪,等.超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系[J].天津医科大学学报,2015,21(01):63.
　LI Xiao-jie,ZHOU Lei,CHEN Xian,et al.Relationship between high-sensitivity C-reactive protein, complement 3 andwith disease activity in systemic lupus erythematosus[J].Journal of Tianjin Medical University,2015,21(04):63.
[4]徐 萍,周 蕾.血清β2-微球蛋白与系统性红斑狼疮疾病活动度及其肾脏损害的相关性[J].天津医科大学学报,2017,23(01):41.
　XU Ping,ZHOU Lei.Relationship between serum levels of β2-microspheres and disease activity together with renal damage in systemic lupus erythematosus patients[J].Journal of Tianjin Medical University,2017,23(04):41.
[5]赵 冕,朱桂晋,周 蕾.系统性红斑狼疮患者血清IL-17和IL-35水平及其与肾损害的关系[J].天津医科大学学报,2019,25(04):359.
　ZHAO Mian,ZHU Gui-jin,ZHOU Lei.Serum IL-17 and IL-35 levels in patients with systemic lupus erythematosus and their correlations with renal damage[J].Journal of Tianjin Medical University,2019,25(04):359.

备注/Memo

备注/Memo:

作者简介 朱桂晋（1992-），女，硕士在读，研究方向：风湿病学；通信作者:周蕾，E-mail：yizhe1234@126.com。

常用功能

更新日期/Last Update: 2019-08-28