|本期目录/Table of Contents|

[1]马晓雷,孙焕君,和西波,等.中国精神分裂症患者认知能损害性别差异的P300证据[J].天津医科大学学报,2019,25(02):167-170.
 MA Xiao-lei,SUN Huan-jun,HE Xi-bo,et al.P300 evidence for the gender difference in cognitive impairment in Chinese patients with schizophrenia[J].Journal of Tianjin Medical University,2019,25(02):167-170.
点击复制

中国精神分裂症患者认知能损害性别差异的P300证据(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年02期
页码:
167-170
栏目:
精神医学
出版日期:
2019-03-20

文章信息/Info

Title:
P300 evidence for the gender difference in cognitive impairment in Chinese patients with schizophrenia
文章编号:
1006-8147(2019)02-0167-04
作者:
马晓雷1孙焕君2和西波2李美娟3李 洁3
(1.天津医科大学研究生院,天津300070;2.天津市安宁医院精神科,天津300300;3.天津市安定医院精神科,天津300222)
Author(s):
MA Xiao-lei1 SUN Huan-jun2 HE Xi-bo2 LI Mei-juan3 LI Jie3
(1.Graduate School, Tianjin Medical University , Tianjin 300070,China; 2. Department of Psychiatric,Tianjin Anning Hospital, Tianjin 300300,China;3. Department of Psychiatric,Tianjin Anding Hospital, Tianjin 300222,China)
关键词:
精神分裂症P300性别Meta分析
Keywords:
schizophreniaP300gendermeta-analysis
分类号:
R749.3
DOI:
-
文献标志码:
A
摘要:
目的:用Meta分析系统评价中国精神分裂症(分裂症)患者的认知电位P300的性别差异。方法:计算机检索中英文数据库,收集对比男性和女性分裂症患者P300潜伏期和波幅的研究文献,按照匹配原则评价纳入研究的质量。采用Meta分析计算男性和女性分裂症患者P300潜伏期和波幅性别差异的标化加权均数差(SMD)。结果:合计9项研究(300例男性和269例女性患者)纳入Meta分析,其中5项为高质量研究。男性患者的P300潜伏期长于女性患者,但P300波幅短于女性患者,其SMD分别为0.28(95%CI: 0.11, 0.44)和-0.56(95%CI: -0.89, -0.23),差异均具有统计学意义(P =0.003和P =0.001)。结论:中国分裂症患者P300潜伏期和波幅存在显著的性别差异。
Abstract:
Objective: To systematically assess the gender difference in the P300 cognitive event-related potential of Chinese patients with schizophrenia. Methods: We searched Chinese and English databases and collected studies to compare P300 latency and amplitude between Chinese male and female schizophrenia patients. Quality of included studies was assessed according to the matching principal. The standardized weighted mean differences (SMDs) of P300 latency and amplitude between male and female patients were calculated by Meta-analysis. Results: Nine studies (300 males and 269 females) were included, 5 of which were judged as having high quality. Male patients had significantly longer P300 latency and lower P300 amplitude than female patients(P =0.003 and P =0.001), and their SMDs were 0.28 (95% CI: 0.11, 0.44) and -0.56(95% CI: -0.89, -0.23), respectively. Conclusion: There are significant gender differences in the P300 latency and amplitude of Chinese patients with schizophrenia.

参考文献/References:


[1] Ochoa S, Usall J, Cobo J, et al. Gender Differences in Schizophrenia and First-Episode Psychosis: A Comprehensive Literature Review[J]. Schizophr Rese Treatment, 2012, 2012(9): 916198
[2] Krysta K, Murawiec S, Klasik A, et al. Sex-specific differences in cognitive functioning among schizophrenia patients[J].Psychiatr Danub, 2013, 25(Suppl2):244
[3] 尚兰,李国旺,费立鹏,等. 不同性别首发精神分裂症患者认知功能损害的比较[J].中国神经精神疾病杂志, 2000, 26(6):360
[4] 王宏,温盛霖,岳计辉,等. 首发未经治疗精神分裂症患者认知功能及其影响因素[J].中国慢性病预防与控制, 2013, 21(5):513
[5] 李艳丽,陈大春,王宁,等. 首发精神分裂症患者临床特征,认知功能的性别差异[J].神经疾病与精神卫生, 2009, 9(4):281
[6] 介勇,汪作为. 不同性别慢性精神分裂症认知功能损害的比较[J].中国民康医学, 2011, 23(11):1320
[7] Han M, Huang X F, Chen D C, et al. Gender differences in cognitive function of patients with chronic schizophrenia[J].Prog Neuropsychopharmacol Biol Psychiatry, 2012, 39(2):358
[8] Dejanovic M, Ivetic V, Nestorovic V, et al.The value of P300 event related potentials in the assessment of cognitive function in subclinical hypothyroidism[J].Minerva Endocrinol, 2017, 42(1):15
[9] 谢娜, 邓建中, 齐进兴. 神经心理测试及P300对皮质下缺血性脑血管病伴认知功能障碍患者评估研究[J].中国实用神经疾病杂志, 2015, 18(1):69
[10] 倪明,郭其.精神分裂症患者P300的性别差异[J].中国现代医学杂志, 2001, 11(6):30
[11] 孙燕,杨红,郭凤莲,等.急性期不同性别精神分裂症患者P300的比较研究[J].中华现代临床医学杂志, 2006, 4(19):1739
[12] 孙浩.首发精神分裂症听觉脑干反应,P50及P300的研究[D].太原:山西医科大学, 2006
[13] 杨士财,王云霞,李宪海,等.不同性别精神分裂症患者视觉,听觉诱发电位事件相关电位P300相关性研究[J].神经疾病与精神卫生, 2007, 7(2):129
[14] 初菊,黄生万.慢性精神分裂症51例的P300结果分析[J].临床神经电生理杂志, 2008,17(5):317
[15] 李海玲,赵后锋,耿德勤,等.不同性别首发精神分裂症患者听觉事件相关电位的研究[J].中国健康心理学杂志, 2011, 19(8):897
[16] 马军平,郑全庆.精神分裂症与躁狂发作患者视觉P300比较研究[J].医药前沿, 2013, 8(24):103
[17] 彭焱,李薇,杜君,等.长期住院精神分裂症患者事件相关电位P300分析研究[J].中国健康心理学杂志, 2014, 22(4):485
[18] Zhong B, Xiang Y, Cao X, et al. Prevalence of antisocial personality disorder among Chinese individuals receiving treatment for heroin dependence:a meta-analysis[J].Shanghai Arch Psychiatry, 2014, 26(5): 259
[19] 徐艳敏,钟宝亮,操小兰,等.华人精神分裂症患者吸烟对住院次数和住院时间影响的Meta分析[J].中国药物依赖性杂志, 2014, 23(3):179
[20] Tsolaki A C, Kosmidou V, Kompatsiaris I Y, et al. Brain source localization of MMN and P300 ERPs in mild cognitive impairment and Alzheimer's disease: a high-density EEG approach[J]. Neurobiol Aging, 2017, 55:190
[21] 蔡亦蕴,苏亮,施慎逊.中国精神分裂症患者认知电位P300研究的系统评价[J].神经疾病与精神卫生, 2012,12(4):364
[22] 黄慧,王晓明,赵小琼,等.正常人听觉P300的初步研究[J].川北医学院学报 ,2005, 20(3):282
[23] 朱莉,程新萍,祝延. 正常人年龄,性别与听觉P300的关系[J].安徽医科大学学报, 2001, 36(2):124
[24] 苏亮,蔡亦蕴,施慎逊,等.中国抗精神病药物治疗精神分裂症患者P300潜伏期和波幅变化的Meta分析[J].上海精神医学, 2012, 24(4):200
[25] Yin E W, Zeyl T, Saab R, et al. An Auditory-Tactile visual Saccade-Independent P300 Brain-Computer interface[J].Int J Neural Syst, 2016, 26(1):1650001

相似文献/References:

[1]陈清刚,钱 明,王 毅,等.首发精神分裂症患者与超高危人群认知功能的对照研究[J].天津医科大学学报,2014,20(03):216.
 CHEN Qing gang,QIAN Ming,WANG Yi,et al.Control study of cognitive function in ultra-high risk population of schizophrenia and first-episode schizophrenia patients[J].Journal of Tianjin Medical University,2014,20(02):216.
[2]程 娟,徐小童,毛富强,等.内观认知疗法改善偏执型精神分裂症康复期社会功能的研究[J].天津医科大学学报,2014,20(04):313.
[3]田 丽,杨 媛,胡永梅.首诊精神分裂症患者的病耻感与社会功能的关系研究[J].天津医科大学学报,2014,20(06):480.
[4]张 静,赵永萍,贾 琼,等.黄连素对利培酮治疗精神分裂症患者症状及糖脂代谢的影响[J].天津医科大学学报,2016,22(04):338.
[5]李慧慧,毛富强,韩邵明,等.内观认知疗法对精神分裂症患者服药依从性的影响[J].天津医科大学学报,2017,23(06):548.
 LI Hui-hui,MAO Fu-qiang,HAN Shao-ming,et al.Effect of Naikan CognitiveTherapy on medication adherence in schizophrenic patients[J].Journal of Tianjin Medical University,2017,23(02):548.
[6]马彦彦,李美娟,仇玉莹,等.盐酸小檗碱对精神分裂症患者脂代谢及C反应蛋白的影响[J].天津医科大学学报,2018,24(02):159.
[7]杜 彬,杨建立.氟西汀辅助治疗前后精神分裂症患者外周血miR-181b 表达差异研究[J].天津医科大学学报,2019,25(01):63.
 DU Bin,YANG Jian-Li.Study on the difference of miR-181b expression in patients with schizophrenia before and after fluoxetine treatment[J].Journal of Tianjin Medical University,2019,25(02):63.
[8]崔 鹏,杨建立.奥卡西平治疗的精神分裂症兴奋激越患者的效果及对血清Hcy的影响[J].天津医科大学学报,2019,25(01):66.
 CUI Peng,YANG Jian-Li.Effect of oxcarbazepine on patients with schizophrenia and excitement and its effect on serum Hcy[J].Journal of Tianjin Medical University,2019,25(02):66.

备注/Memo

备注/Memo:
作者简介 马晓雷(1984-),男,主治医师,硕士在读,研究方向:精神疾病电生理学;通信作者:李洁,E-mail: tjlijie3827@163.com。
更新日期/Last Update: 2019-04-25