|本期目录/Table of Contents|

[1]闫常帅,胡 芳,张 杰.超声造影在大动脉炎颈动脉受累患者疾病活动性判断及治疗评价中的应用[J].天津医科大学学报,2019,25(01):47-50,58.
　YAN Chang-shuai,HU Fang,ZHANG Jie.Application of contrast-enhanced ultrasonography（CEUS） in Takayasu arteritis patients with carotid artery involvement：assessment of diseaseactivity and medicinal curative effect[J].Journal of Tianjin Medical University,2019,25(01):47-50,58.
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超声造影在大动脉炎颈动脉受累患者疾病活动性判断及治疗评价中的应用(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年01期
页码:
47-50,58
栏目:
临床医学
出版日期:
2019-01-20

文章信息/Info

Title:
Application of contrast-enhanced ultrasonography（CEUS） in Takayasu arteritis patients with carotid artery involvement：assessment of diseaseactivity and medicinal curative effect
文章编号:
1006-8147(2019)01-0047-04
作者:
闫常帅1; 2; 胡 芳2; 张 杰1
（天津医科大学总医院1.普通外科；2.护理部，天津 300052）
Author(s):
YAN Chang-shuai1; 2; HU Fang2; ZHANG Jie1
（1.Department of General Surgery, 2.Department of Nursing, General Hospital, Tianjin Medical University, Tianjin 300052, China）
关键词:
多发性大动脉炎; 颈动脉; 超声造影; 治疗评价
Keywords:
takayasu arteritis; carotid artery; contrast-enhanced ultrasonography; treatment evaluation
分类号:
R445.1
DOI:
-
文献标志码:
A
摘要:
目的：探讨超声造影在多发性大动脉炎（TA）颈动脉受累患者疾病活动性判断及治疗评价中的应用。方法：17例大动脉炎颈动脉受累患者依临床标准分为活动期和非活动期组，以超声造影观察两组增强特点并对两组药物治疗过程中疾病活动性进行评价。结果：17例大动脉炎患者（15例双侧受累，2例单侧受累），共计32条颈动脉受累，其中30条存在造影剂增强，2条未见明显增强；活动期超声造影表现为弥漫点状或短线状灌注,非活动期则表现为无灌注或散在点状灌注，差异有统计学意义（P<0.05）；治疗评价过程中，患者在药物治疗前后上述增强特点差异有统计学意义（P<0.05），药物治疗后造影剂增强特点由原来的弥漫点状或短线状灌注变为无灌注或散在点状灌注；以超声造影判断活动性的灵敏度为81.0%，特异度为81.8%，假阳性率为18.2%，假阴性率为19.1%。结论：超声造影对大动脉炎颈动脉受累患者的活动性具有良好的判断效果，在治疗评价中具有重要应用价值。
Abstract:
Objective: To explore the application of contrast-enhanced ultrasonography in the disease activity and treatment evaluation in Takayasu arteritis（TA）patients with carotid artery involvement. Methods：Seventeen TA patients with carotid artery involvement were divided into active and inactive group according to clinical criteria. Their enhancement behaviors and disease activity during the course of drug treatment in two groups by CEUS were enhanced .Results: There were 32 carotid arteries from 17 cases of TA patients (15 cases of bilateral involvement, and 2 cases of unilateral involvement) in our research. Thirty of them presented positive contrast enhancement while the other 2 cases showed negative result. Significant statistical difference between active and inactive group was showed by revealing diffuse punctate or shortlinear perfusion in the active group and no perfusion or scattered perfusion in the other group (P<0.05). There was also significant difference in CEUS result between before and after medicine treatment (P<0.05). Contrast enhancement characteristics were turned into no perfusion or scattered perfusion from diffuse punctate or shortlinear perfusion after medicine treatment. The sensitivity，specificity，false positiverate and false negative rate were 81.0%，81.8%，18.2% and 19.1% respectively and disease activity was evaluated with CEUS. Conclusion：Contrast-enhanced ultrasonography exerts an excellent effect on the disease activity evaluation of TA patients with carotid artery involvement and have great value in medicinal treatment assessment.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目 天津市教委科研计划项目资助（2017KJ196）
作者简介 闫常帅（1992-），女，护师，硕士在读，研究方向：超声介入护理；通信作者：张杰，E-mail： wxq_bf@163.com。
更新日期/Last Update: 2019-03-01